Recombinant Rat C-type natriuretic peptide (Nppc)

1. C-type Natriuretic Peptide Knock-out rats survive over one year, and exhibit a deficit in endochondral bone growth and growth retardation throughout life. PMID: 29566041
2. Cardiac CNP and NPR-B play an important role in exercise preconditioning-mediated cardioprotection against high-intensity exercise-induced myocardial injury in rats. PMID: 27557795
3. C-type natriuretic peptide reduces cardiac sympathetic neurotransmission via a reduction in neuronal calcium signalling and NE release through the NPR-B receptor. Situations impairing CNP-NPR-B signalling lead to hypertension, tachycardia, and impaired left ventricular systolic function secondary to sympatho-excitation. PMID: 27496871
4. A significant direct relationship was determined between plasma CNP levels and prolonged intervals of mesenteric ischaemia. PMID: 24967686
5. The CNP/NPR-B pathway is upregulated in the rectum of depressed rats and may be one mechanism for depression-associated digestive disorders. Xiaoyaosan antagonizes this pathway at least partially. PMID: 25663771
6. Study findings suggest that CNP could ameliorate ischemia-reperfusion-induced acute kidney injury through inhibition of apoptotic and oxidative stress pathways, possibly through natriuretic peptide receptor-B-cGMP signaling PMID: 25283078
7. We conclude that CNP-induced phospholamban and troponin I phosphorylation by protein kinase G in concert mediate both a predictable positive lusitropic responses as well as the less expected negative inotropic in failing hearts PMID: 23808942
8. results suggest that cGMP-PDE3-cAMP signal pathway is also involved in the CNP-induced inhibition of gastric motility in rat PMID: 23186653
9. Expression of C-type natriuretic peptide (CNP) in cardiac cells at gene and protein levels suggests that the heart is actively involved in the production of CNP. PMID: 21723350
10. urinary C-type natriuretic peptide could potentially aid in identifying subjects with preclinical structural changes before the onset of symptoms and disease PMID: 21865266
11. The gene expression levels of CNP/NPR-B in rat testes at different postnatal stages and in infertile testes indicated that CNP may participate in the physiology and/or pathology related to spermatogenesis. PMID: 21170077
12. Data show that a progressive decline in circulating CNP characterizes natural aging and is strongly associated with a reciprocal increase in LV fibrosis that precedes impairment of diastolic and systolic function. PMID: 21189408
13. CNP is involved in the regulation of bidirectional plasticity in area CA1 potentially by modulating GABA(A)-mediated inhibition and NMDA receptors. PMID: 20438814
14. endothelial-derived CNP has a role in the regulation of vascular tone and blood flow PMID: 12552127
15. CNP produced by cardiac fibroblasts may play a role as an autocrine regulator against excessive cardiac fibrosis. PMID: 12746286
16. pituitary adenylate cyclase-activating polypeptide might be involved in the regulation of C-type natriuretic peptide biosynthesis in astrocytes PMID: 16888179
17. CNP secreted by Sertoli and germ cells into the blood-testis barrier (BTB)microenvironment regulates BTB dynamics during spermatogenesis PMID: 17360440
18. Depression of CNP-dependent cGMP-mediated [Ca2+]i accumulation may contribute to cerebral vascular endothelial dysfunction associated with hyperammonemia or hepatic encephalopathy. PMID: 18222015

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KEGG: rno:114593

STRING: 10116.ENSRNOP00000025582

UniGene: Rn.10637