Recombinant Rat Cocaine- and amphetamine-regulated transcript protein (Cartpt)

1. impaired CART mRNA expression in the anterior Paraventricular nucleus and Lateral hypothalamic area could be related to the aberrant feeding behaviour of dehydration-induced anorexic rats but not to their deregulated HPT axis function. PMID: 28984394
2. The results indicate that Cocaine and Amphetamine-Regulated Transcript (CART) can directly affect the physiological release of hormones in pituitary cells of starved animals. PMID: 28300671
3. As the observed results are in agreement with data regarding the CART mRNA and protein expression in the brain reward pathway in opioid addiction phases, it may be suggested that evaluation of CART peptide level in CSF or plasma could be a suitable marker which reflects the rises and falls of the peptide concentration in brain in the development of opioid addiction PMID: 27349817
4. Results suggest that CART plays an important role in recognition memory and that these effects may be mediated by NMDA receptors-ERK signaling in the entorhinal/perirhinal -hippocampal circuit. PMID: 27258934
5. CART is important for maintaining the beta-cell phenotype. PMID: 28237718
6. Study found that the distribution and intensity of CART staining in the nodose ganglion looked identical in fed and fasted rats when observed under blinded conditions and the density of CART-positive profiles across the ganglion was not significantly different in fed and fasted rats. PMID: 27822503
7. Cocaine- and amphetamine-regulated transcript (CART) mRNA and protein were both up-regulated in morphine-administered animals and also in the withdrawal group in the nucleus accumbens (NAc), striatum and prefrontal cortex (PFC). In the addicted group, CART mRNA and protein were both down-regulated in NAc and striatum. PMID: 26955782
8. These findings suggest that islet-derived CART is involved, at least in part, in high glucose-potentiated pancreatic beta-cell function. PMID: 27823935
9. These results suggest that endogenous CART might closely interact with the dopamine containing substantia nigra-striatal pathway which is known to profoundly influence the motor system PMID: 26771081
10. The study gives rise to the assumption that high blood pressure can be a factor that intensifies CART secretion PMID: 26150151
11. Results suggest that there might be two partly overlapping brain circuits involved in the neurobiology of binge eating, both driven by CART PMID: 26008155
12. Results suggest that oxidative stress in the brain participates in regulating NPY/CART-mediated appetite control in amphetamine-treated rats. PMID: 25825358
13. Elevated circulating progesterone concentration up-regulated NPY and down-regulated CART genes expression in hypothalamus of females and caused an increase in food intake and white adipose tissue mass. PMID: 24549602
14. Renal vascular reactivity is associated with up regulation of renal endothelin receptors type A. PMID: 24989426
15. Cart expression decreased in the arcuate nucleus of the hypothalamus in polydipsic rats. PMID: 24647922
16. Acumbal-CART peptide reduces anxiety-like behavior in a dose-dependent manner. PMID: 25256086
17. We demonstrated that renovascular hypertension alters the number and immunoreactivity of CART-containing cells in adrenal glands PMID: 25151991
18. These data demonstrate that CART peptide-expressing neurons are belong to a sparcely branched neuronal system. PMID: 25552080
19. CART peptide is effective in blunting dopaine- and cocaine-mediated locomoter activity in both males and females. PMID: 24630272
20. CART is relevant to the regulation of homeostasis in the cardiovascular system and seems to be involved in renovascular hypertension. PMID: 24939825
21. The orexigenic effects of omentin-1 could be related, at least in part, to decreased CART and CRH gene expression. PMID: 23538212
22. factors secondary to obesity and/or diabetes rather than impaired CCK-1 receptor signaling may contribute to altered CART expression PMID: 23545074
23. CART was detected in the extensive population of neurons, particularly within the myenteric plexuses all along the GI tract, and also in neuroendocrine cells, being especially numerous in the stomach and a few in the small intestine. PMID: 22887004
24. This study demonistrated that CART mRNA regulation by acute morphine or cocaine in the nucleus accumbens does not seem predictive of addiction vulnerability. PMID: 23907376
25. work suggests that CART is functional in inhibiting the cerebral I/R-induced ER stress and neuronal apoptosis by facilitating the transcription, synthesis and secretion of BDNF in a CREB-dependent way PMID: 23770418
26. CART is a novel constituent of human and rat adipocytes and affects several biological processes central in both lipid- and glucose homeostasis PMID: 23318496
27. Forced swim stress elicits region- and sex-specific changes in CART mRNA expression in hypothalamic nuclei. PMID: 22960117
28. study was designed to reveal the projection patterns of lateral hypothalamic (LH), cocaine- and amphetamine-regulated transcript (CART) neurons to the dorsal raphe (DR) and/or the locus coeruleus (LC) in the rat. PMID: 23206801
29. The effect of exogenous CART 55-102 on beta cell viability was examined. PMID: 23250745
30. Cocaine- and amphetamine-regulated transcript increased the expression of GAP43 and fluoro-ruby fluorescence in the lesioned cortex. In conclusion, our data suggest that intranasal CART treatment facilitates neuroregeneration in stroke brain. PMID: 23211962
31. activation of CARTergic neurons in stria to-nigral projections testifies on participation of CART-peptide in compensatory brain mechanisms at dopamine loss PMID: 23155622
32. CART peptide in brain regions and adrenal glands regulates the hypothalamo-pituitary-adrenal system and sympatho-adrenal axis activity during stress responses. PMID: 22137563
33. CART is expressed in climbing fiber bands in all four transverse zones of the rat cerebellum, reflecting species-specific compartmental features. PMID: 21452228
34. Our findings indicate that CART gene expression is induced in a distinct temporal and spatial manner in forebrain PMID: 21903152
35. Food deprivation for 48 h significantly increased neuropeptide Y mRNA level, and decreased that of proopiomelanocortin and cocaine-amphetamine regulated transcript, in the arcuate nucleus of female pups separated from their mothers. PMID: 21821286
36. CART is involved in activation of the hypothalamo-hypophyseal axis and cardiovascular regulation in response to changes in extracellular volume and osmolality. PMID: 21539900
37. Brain morphologic study serves as basis for the biological significance of lateral septal CART peptide in regulation of food intake. PMID: 20883668
38. CART mRNA expression is increased in the arcuate nucleus (ARC) following food intake on a high-fat diet, which may stimulate release of hypothalamic orexigenic neuropeptides in the ARC of diabetic rats. PMID: 20626417
39. CART is able to modulate hormonal profile in a non-starved rats; however, the modulatory effect depends on the CART administration method PMID: 21407156
40. The CART innervation of dorsal raphe nucleus, locus coeruleus and ventrolateral periaqueductal gray may be involved in the central processing of neuropathic pain. PMID: 21167239
41. CART signaling within the paraventricular thalamus inhibits drug-primed reinstatement of cocaine seeking. PMID: 20886038
42. The results suggest that CARTp activation of ERK signals via the NMDA receptor in the spinal cord dorsal horn was age-dependent. PMID: 20595030
43. study shows novel role for CART neuropeptide in inhibiting renewal of extinguished alcoholic beer seeking apparently by reducing reinstatement by acting selectively to reduce the incentive motivational properties of the reward associated training context PMID: 20528087
44. CART immunoreactivity may identify postulated accessory preganglionic neurons whose actions in the rat may amplify vasomotor ganglionic transmission. PMID: 20810898
45. These findings point to a potential novel role for CART in regulating wakefulness. PMID: 20116848
46. Cocaine- and amphetamine-regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons. PMID: 19854189
47. CART peptide is present in the NAcc to VP projection and likely plays a role in the motor functionality of the VP. PMID: 19825396
48. Data found that BDNF, CART are colocalized in in the midbrain non-preganglionic Edinger-Westphal nucleus. Immunocytochemistry revealed a 16% lower number of BDNF-immunoreactive neurons, and 19% lower CART-immunoreactivity in females compared to males. PMID: 19755135
49. results provide the first evidence that CARTp increases the phosphorylation of NMDA receptor NR1 subunit via activation of PKA and PKC signals, which may play a crucial role in CARTp regulation of spinal NMDA receptor-mediated nociceptive responses PMID: 19632277
50. was detected in neurons of the rostral ventrolateral medulla (RVLM), but few in the caudal ventrolateral medulla (CVLM). PMID: 11841916

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KEGG: rno:29131

STRING: 10116.ENSRNOP00000023869

UniGene: Rn.89164