Recombinant Rat Kalirin (Kalrn), partial

1. Mass spectrometry was used to quantify phosphorylation at 26 sites in Kal7 from individual adult rat nucleus accumbens and prefrontal cortex before and after exposure to acute or chronic cocaine. Region- and isoform-specific phosphorylation was observed along with region-specific effects of cocaine on Kal7 phosphorylation. Calpain cleaved Kal7 at 2 sites, separating N-terminal domain and PDZ binding motif from GEF domain. PMID: 28418645
2. These results suggest that kalirin and Rac1 guanine nucleotide exchange factor play important roles in FSTL-1-mediated glucose regulation in skeletal muscle cells. PMID: 27989699
3. Chronic unpredictable mild stress alters structural plasticity in the orbitofrontal cortex and is associated with decreased expression of kalirin. PMID: 26921771
4. Results demonstrate that both endogenous kalirin-9 and endogenous kalirin-12 contribute to dendritic maturation in early development. PMID: 25146373
5. The effects of NRG1 and erbB4 on spines were mediated by the RacGEF kalirin PMID: 23742124
6. Knock-down of kalirin-7 abolishes AMPA receptor and dendritic spine upregulation normally seen during cocaine withdrawal. PMID: 23825406
7. The rigidity and flexibility of the nine spectrin repeats of Kal7, which separate its essential N-terminal Sec14p domain from its catalytic domain, play an essential role in its contribution to the formation and function of dendritic spines. PMID: 22738176
8. our findings indicate that kalirin-7 is differentially compartmentalized in spines as a function of both synapse morphology and spine size. PMID: 22458534
9. Estradiol treatment of cultured hippocampal neurons increased Kal7 levels at the postsynaptic side of excitatory synapses PMID: 20333733
10. results explain why Rac1 and its activator (Kal-7) serve as important mediators of spine enlargement and why constitutive Rac1 activation decreases spine size PMID: 20139976
11. Reduced expression of Kalirin in CA1 hippocampal neurons resulted in a reduction in linear spine density, with dispersion of postsynaptic density markers and elimination of presynaptic endings PMID: 14627644
12. we have identified multiple transcriptional start sites in rats and humans. These multiple transcriptional start sites result in full-length Kalirin transcripts possessing different 5' ends encoding proteins with differing amino termini PMID: 14742910
13. Data demonstrate that Kalirin binds to and colocalizes with the TrkA neurotrophin receptor in neurons. PMID: 15923627
14. a novel molecular mechanism whereby intramolecular and intermolecular Kalirin SH3 domain/ligand interactions modulate GEF activity, a regulatory mechanism that is likely used by other RhoGEF family members PMID: 16644733
15. NMDA receptor activation in pyramidal neurons causes CaMKII-dependent phosphorylation of kalirin-7 at threonine 95, regulating its GEF activity, leading to activation of small GTPase Rac1 and rapid enlargement of existing spines. PMID: 18031682
16. Sec14p and N-terminal spectrin-like domains of Kalirin play critical roles in distinguishing the actions of full-length and Delta-Kalirin proteins. PMID: 18585704
17. Kalirin9, a dual RhoGEF, binds p75 directly and regulates p75-Nogo receptor-dependent RhoA activation and neurite inhibition in response to myelin-associated glycoprotein. PMID: 18625710
18. The presence of Thr1590 in each major Kalirin isoform would allow Cdk5 to regulate Kalirin function throughout development PMID: 18628310

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KEGG: rno:84009

STRING: 10116.ENSRNOP00000039072

UniGene: Rn.87882