Recombinant Rat Protachykinin-1 (Tac1)

1. These findings reported here for the first time suggest an important role for a SP/NK1R system, either as genetic and/or epigenetic factor, in both the cytoplasm and nucleus functions of the adipose stem cells. PMID: 28500728
2. Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in rats PMID: 28685530
3. Inferior alveolar nerve injury did not change the expression of GluA1, GluA2 and CGRP, but increased the expression of TRPV1 and substance P. PMID: 28337884
4. The expression and distribution of SP and NK1R along the brain-gut axis in neonatal maternal separation rat. PMID: 27706667
5. the present molecular and immunocytochemistry studies showed that there existed intrinsic substance P (SP) expression in the neurons of intrapancreatic ganglia, which constituted around half of SP origins in the pancreas suggesting that intrapancreatic ganglia might play an important role on mechanisms involving SP. PMID: 27431609
6. The findings of this study suggested that there is an increased mobilization of SubP within processes in the RVM shortly after injury accompanied by an increased synthesis of SubP in neurons that project to the RVM. PMID: 26762802
7. Tong Xie Yao Fang can modulate the activity of the enteric nervous system and alter 5-HT and SP activities, which may contribute to the symptoms of irritable bowel syndrome. PMID: 25914462
8. rodent and non-human primate cardiac fibroblasts showed similar responses in genes that relate to ECM regulation and cell adhesion in response to SP. PMID: 25550118
9. The spatial structures of human, mouse, and rat hemokinin-1 protein isoforms have been presented. PMID: 26349209
10. Data demonstrate a role TAC1 in the control energy balance by regulating the levels of adiposity in response to ghrelin administration and to changes in the status of the gonadal function. PMID: 25751638
11. The identification of Dex/forskolin response elements in the TAC1 promoter in amygdala neurones suggests a possible link in the chain of molecular events connecting GR activation and anxiety. PMID: 25001955
12. Induction of diabetes leads to the increase of cell apoptosis and the decrease of substance P in the retina. PMID: 24045094
13. Shugan-decoction can reduce chronic stress-induced visceral hypersensitivity in rats, and the regulatory mechanism may involve mediating the expression of substannce P in colon tissues. PMID: 24307802
14. Villous subepithelial fibroblasts and afferent neurons interact via ATP and substance P. PMID: 23809436
15. Sympathetic terminals in targets, in contrast to ganglion perikarya and processes, contain negligible quantities of SP. PMID: 24010178
16. Downregulation of annexin A2 significantly inhibits divalent calcium ion influx and substance P mediated by TRPV4. PMID: 22762361
17. Substance P is a pleiotropic early regulator of mRNA levels of key adhesiogenic mediators after surgery, suggesting that it may be a viable therapeutic target PMID: 22765994
18. Studied effects of ultrafine titanium dioxide (UFTiO(2)) on the heart.Pulmonary exposure of rats to UFTiO(2) increased the phosphorylation levels of p38 MAPK and cardiac troponin I, but not Akt, in the heart and substance P synthesis in nodose ganglia. PMID: 21877901
19. A TRPV1 mechanism mediates cardiac ischemia-induced release of substance P in the spinal cord. PMID: 22525132
20. Substace P is implicated in the stimulation of neurogenesis and has the potential to promote recovery following traumatic brain injury. PMID: 22531375
21. PACAP caused a concentration-dependent increase in the expression of the substance P precursor mRNA in a rat sensory neuronal cell line. PMID: 22418790
22. Substance P is a potential anti-inflammatory modulator for the treatment of injury-induced inflammatory central nervous system disorders. PMID: 22825006
23. Substance P, tyrosine hydroxylase and serotonin are not always co-localized in terminals forming inputs with laryngeal motoneurons; they arise from separate subpopulations of neurons. PMID: 21689789
24. Both reactive oxygen species and substance P are involved in perinatal hypoxia-augmented, monocrotaline-induced pulmonary hypertension. PMID: 22559732
25. PREP is not significantly responsible for the in vivo extracellular space cleavage of substance P or neurotensin. PMID: 21820035
26. Data implicate USF1 as a major regulator of the action of lithium on the proximal preprotachykinin promoter. PMID: 20690045
27. Substance P may be important in mediating adverse myocardial remodelling secondary to volume overload by activating cardiac mast cells, leading to increased TNF-alpha and MMP activation with subsequent degradation of the extracellular matrix. PMID: 21908647
28. *esults show that the neurokinin 1 receptor mediates the role of substance P in learning and memory in the marginal division of the neostriatum. PMID: 21611833
29. The cardioprotection role of substance P release in non-diabetic and diabetic rat hearts PMID: 21554904
30. This study therefore assessed whether Substance P mediates edema formation in experimental subarachnoid hemorrhage PMID: 21377453
31. Immunohistochemical studies showed a statistically significant reduction of SP in the bladders from the diabetic group compared with the control (P < 0.05). PMID: 20490673
32. Substance P expression in masseter muscles increased following experimental occlusal interference. PMID: 20140043
33. The expression of substance P and CGRP increased significantly in primary cultured DRG neurons in the presence of IGF-1. PMID: 20942583
34. Data suggest that SP release from nerve fibers, lymphocytes and mast cells together with TNF-alpha can enhance the development of gastric inflammation and participate in tissue damage in gastritis. PMID: 20865295
35. neuronal SP during bone regeneration has a stimulatory role on bone formation, while during remodeling increased SP fiber density in unloaded areas may be related to bone resorption. PMID: 20540103
36. locomotor training activates mechanisms in a similar way to LTP, and is involved in the synaptic plasticity in the spinal cord. Such events appear not to be directly influenced by SP, suggesting a process that differs from those triggered by nociception. PMID: 20546710
37. Data show that expression of substance P was observed in the dorsal root ganglion of the first lumbar vertebra. PMID: 20535049
38. findings indicate that CB1 receptors facilitate substance P release by inhibiting the release of GABA and opioids next to primary afferent terminals, producing disinhibition; this results in a pronociceptive effect of CB1 receptors in the spinal cord PMID: 20074214
39. Chronic prostatitis pain could upregulate the expressions of the excitatory transmitter SP and NK1 receptor in the L5-S2 spinal cord, which may be associated with the persistence and generalization of prostatitis pain. PMID: 20218316
40. In repetitive strain injury, substance P immunoexpression increased in week 12 peritendon as did CTGF-immunopositive fibroblasts. PMID: 19743505
41. Taken together, these findings indicate locally collateralizing glutamate neurons responsive to substance P contain VGLUT3. PMID: 19467322
42. Substance p involved in vascular reactivity PMID: 11882578
43. Involvement of the second extracellular loop (E2) of the neurokinin-1 receptor in the binding of substance P PMID: 11950831
44. substance P may activate, via neurokinin-1 receptors, a hyperplastic but not hypertrophic response in adult cardiac fibroblasts PMID: 11959652
45. melatonin may regulate tachykinin stores during aging mainly on structures of the neuroendocrine-reproductive axis PMID: 12084526
46. Immunoreactive substance P is not part of the retinohypothalamic tract in the rat. PMID: 12172789
47. Sensory nerve fibers containing substance P are distributed more abundantly in the superficial muscle layer of the dorsum than in the deeper layers and may be involved in the regulation of local blood flow. PMID: 12183023
48. there is an increase of the releasable pool of substance P in the dorsal horn at late post-operative times after partial sciatic nerve ligation PMID: 12372698
49. The increased levels of mRNA for substance P, the neurokinin-1 receptor, and the downstream mediators of substance P action in peritoneal tissue associated with intraabdominal adhesions support a role for substance P in adhesion formation. PMID: 12443729
50. Substance P plays a role in proinflammatory cytokine-induced leakage of the blood-brain barrier. PMID: 12458035

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KEGG: rno:24806

STRING: 10116.ENSRNOP00000009888

UniGene: Rn.1920