Recombinant Rat SMR1 protein (Vcsa1)

Code CSB-YP320225RA
MSDS
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Source Yeast
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Code CSB-EP320225RA
MSDS
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Source E.coli
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Code CSB-EP320225RA-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP320225RA
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP320225RA
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Vcsa1
Uniprot No.
Alternative Names
Vcsa1; Smr1; SMR1 protein; VCS-alpha 1) [Cleaved into: SMR1-related undecapeptide; SMR1-related hexapeptide; Sialorphin; SMR1-related pentapeptide); Submandibular gland peptide T; SGP-T)]
Species
Rattus norvegicus (Rat)
Expression Region
23-146
Target Protein Sequence
VRGPRRQH NPRRQQDPST LPHYLGLQPD PNGGQIGVTI TIPLNLQPPR VLVNLPGFIT GPPLVVQGTT EYQYQWQLTA PDPTPLSNPP TQLHSTEQAN TKTDAKISNT TATTQNSTDI FEGGGK
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Sialorphin may be involved in the modulation of mineral balance between at least four systems: kidney, bone, tooth and circulation.; Submandibular gland peptide T is able to directly or indirectly down-regulate cardiovascular depression induced by septic shock (endotoxin stimuli), or anaphylactic challenge (nematode antigen sensitization).; Sialorphin is an endogenous inhibitor of neprilysin. Inhibits the breakdown of Met-enkephalin and substance P in isolated tissue from the dorsal zone of the rat spinal cord. Has an analgesic effect when administered to rats by intravenous injection.
Gene References into Functions
  1. When rat corporal smooth muscle cells were treated with CoCl2 or low oxygen tension to mimic hypoxia, Vcsa1 was increased tenfold. PMID: 24803544
  2. Sialorphin protects endogenous enkephalins released after nociceptive stimuli by inhibiting neprilysin in vivo. It is a natural systemically active regulator of NEP activity & is a physiological modulator of pain perception after injury PMID: 12835417
  3. Sialorphin increased, in a dose-related manner, the occurrence of intromissions across the successive ejaculatory sequences. PMID: 15555512
  4. Autonomic nervous system regulates secretion of anti-inflammatory prohormone SMR1 from rat salivary glands. PMID: 19109528
  5. correlation of erectile function, testosterone levels and Vcsa1 expression in orchiectomized rats and controls PMID: 19428993

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Subcellular Location
Secreted. Note=Found in blood. Secreted from the salivary compartment into the blood circulation, rather than through absorption by the gastro-intestinal tract.
Tissue Specificity
Expressed predominantly in the acinar cells of the submandibular gland and to lesser extent in the prostate.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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