Recombinant Rat Sodium channel protein type 8 subunit alpha (Scn8a), partial

1. To clarify the exact expression patterns of Nav1.6 during epileptogenesis, we examined the expression of Nav1.6 at protein and mRNA levels in two distinct models of temporal lobe epilepsy including a post-status epilepticus model induced by kainic acid intrahippocampal injection and a kindling model evoked by pentylenetetrazole. PMID: 27905510
2. Data strongly suggest that voltage-gated sodium channel subunit alpha Nav1.6 ( Nav1.6) plays an indispensable role in the peripheral pain hypersensitivity induced by BmK I. PMID: 28655185
3. Study provides insight into the dynamics of Nav1.6 on the cell surface and raises new questions such as how somatic localization and function are linked and how localized regulation of these channels may influence overall neuronal physiology. PMID: 27653482
4. The data support a model where ankyrinG-binding is required for preferential Nav1.6 insertion into the axon initial segment plasma membrane during development. PMID: 25874799
5. Results highlight the relative importance of abnormal sensory neuron spontaneous activity in establishing both pain behaviors and sympathetic sprouting, and suggest that the NaV1.6 isoform may have value as a therapeutic target PMID: 25686526
6. This study demonistrated that Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia in rats. PMID: 23622763
7. inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons. PMID: 23640885
8. Deltamethrin and tefluthrin (but not S-bioallethrin) bind to Na(v)1.6Q3 channels in the open state and imply that the pyrethroid receptor of resting and open channels occupies different conformations that exhibit distinct structure-activity relationships. PMID: 22465659
9. Data demonstrate that the two N-terminal alternatively spliced FGF14 variants, FGF14-1a and FGF14-1b, differentially regulate currents produced by Nav1.2 and Nav1.6 channels. PMID: 19465131
10. These results identify unique effects of the beta1 and beta2 subunits and demonstrate that joint modulation by both auxiliary subunits gives Nav1.6 properties that are not predicted by the effects of individual subunits. PMID: 21439942
11. study revealed presence of the Nav1.6 subunit in hippocampal CA1 pyramidal cell proximal & distal dendrites; results reveal characteristic subcellular distribution of the Nav1.6 subunit, identifying it as a key substrate enabling dendritic excitability PMID: 20466935
12. FHF2 is abundantly expressed in the hippocampus and DRG neurons and colocalizes with Na(v)1.6 at mature nodes of Ranvier in myelinated sensory fibers in the dorsal root of the sciatic nerve. PMID: 15282281
13. Nav1.6 and p38 are colocalized in rat cerebellar Purkinje neurons suggesting the possibility that p38 can phosphorylate the channel in vivo. PMID: 16014723
14. Nav1.1 and Nav1.6 are the dominant subunits in the sinoatrial node (SAN), and downregulation of Nav1.1 and Nav1.6 expression contributes to heart failure-induced SAN dysfunction. PMID: 17273863
15. The changes identified in this study suggest that the participation of Nav1.6 should be considered when examining changes in the excitability of myelinated axons in neuropathic pain models. PMID: 17662136
16. both SCN8A and ankyrin-G increased significantly in the CA1 subfield of the rat hippocampus 60 days following pilocarpine induced status epilepticus and co-localized with each other PMID: 19306853

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KEGG: rno:29710

STRING: 10116.ENSRNOP00000008160

UniGene: Rn.91216