Recombinant Rat Tribbles homolog 3 (Trib3)

1. TRB3 participated in the global cerebral ischemia and reperfusion injury-induced neuronal apoptosis PMID: 28782643
2. Silencing of TRB3 has a significant ameliorative effect on diabetic nephropathy in rats. PMID: 28600485
3. data suggest that TRB3 mediates AGE-induced oxidative injury in beta-cells through the PKCbeta2 pathway. PMID: 28534945
4. The TRB3 silencing alleviated adipocytes insulin resistance. With TRB3 gene silencing, protein levels of IRS-1, GLUT4 and p-AMPK were significantly increased in adipocytes. TRB3 gene silencing decreased blood glucose, ameliorated insulin sensitivity and adipose tissue remodeling in diabetic rats. TRB3 silencing decreased triglyceride, increased glycogen simultaneously in diabetic epididymal and brown adipose tissues (BAT) PMID: 28476619
5. Trib3 may be associated with the pathogenic mechanism of demyelination in dmy rats. PMID: 27977799
6. results suggest that a self-amplifying feed-forward loop among Trib3, Akt, and FoxO1 in Abeta-treated neurons induces both apoptosis and autophagy, culminating in neuron death PMID: 28011637
7. Diabetic rats displayed increased aortic medial thickness, excessive collagen deposition, diminished elastic fibres and reduced vascular compliance with Tribbles 3 overexpression. Trib3 silencing reversed pathological aortic remodeling in diabetic rats. PMID: 26410836
8. Findings suggest a role for TRIB3 in the development of acute insulin resistance following injury PMID: 26818585
9. TRB3 plays an important role in stretch-induced cardiomyocyte apoptosis. PMID: 25898323
10. Taken together, these results suggest that TRB3 mediates renal tubular cell apoptosis induced by protein overload, broadening our understanding of the pathogenesis of progressive proteinuric kidney diseases. PMID: 24925634
11. Trib3 interferes with the Parkinson's disease-associated prosurvival protein Parkin to mediate death PMID: 26224857
12. Upregulated TRIB3 expression could induce renal fibrosis accompanied by increased phosphorylation of extracellular signal-regulated kinase. PMID: 24368111
13. knockdown of TRIB3 inhibited, and TRIB3 overexpression enhanced, the ability of both high glucose and glucosamine to induce insulin resistance. PMID: 23990361
14. TRB3 may serve as a negative regulator of pro-inflammatory cytokines and chemokines, controlling the extent of the inflammatory response. PMID: 23000510
15. It was shown that TRIB3 impacts glucose uptake and oxidation oppositely in muscle and fat. The data implicated TRIB3 for the first time as a potent physiological regulator of insulin sensitivity and mitochondrial glucose oxidation. PMID: 22850683
16. investigation into whether TRB3 plays a major role in diabetic cardiomyopathy (DCM) and the mechanisms involved: TRB3 gene silencing may exert a protective effect on DCM by improving selective insulin resistance. PMID: 21933987
17. CHOP and ATF4 might mediate PA-induced TRIB3 expression and, by extension, the suppression of IL6 activation of pro-survival kinase AKT. PMID: 20488947
18. These data identify TRIB3 induction as a novel molecular mechanism in human insulin resistance and diabetes. PMID: 19996382
19. The present study does not support the hypothesis that the physiological role of TRB3/NIPK might be to put a brake on insulin signalling in hepatocytes. PMID: 15469416
20. TRB3 has a role in inhibition of Akt/protein kinase B activation PMID: 16452480
21. TRB3 may be involved in metabolic syndrome by inhibiting activation of Akt in adipose tissue. PMID: 18497449
22. Data demonstrated that overexpression of TRIB3 mimicked the glucotoxic effects on insulin secretion and cell growth in INS1 cells. Induction of TRIB3 synergistically enhanced high-glucose-elicited apoptosis. PMID: 18818302
23. blocks insulin signaling by inhibiting Akt activation, which contributes to insulin resistance; may be an important factor in the occurrence and development of fatty liver PMID: 19452573

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KEGG: rno:246273

STRING: 10116.ENSRNOP00000009840

UniGene: Rn.22325