Recombinant Rat Urotensin-2 (Uts2)

1. Aldosterone and its receptors were expressed on tunica adventitia. Urotensin II promoted ALD protein secretion from cells in a dose and timedependent manner. PMID: 29257277
2. IRF3 expression and activation depend on the signal transduction of the the urotensin II/urotensin receptor (UII/UT) system, and play important roles in UII/UT-mediated immune inflammatory injury in the liver PMID: 27448985
3. This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation PMID: 27208703
4. results suggest that GRK5 may be involved in a UII-mediated hypertrophic response via activation of NF-kappaB and HDAC5 at least in part by ERK1/2 and GSK3alpha/beta-independent pathways. PMID: 27613164
5. This study investigates the role and mode of action of urotensin II (U II) in the occurrence and progression of cardiac fibrosis in a pressureoverload rat model. PMID: 26323194
6. Urotensin II expression was increased significantly in brain from focal cerebral ischemia animals. PMID: 24878476
7. The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-kappaB pathways in LPS-stimulated Kupffer cells. PMID: 25803040
8. MDA-MB-231 displayed a statistically significant higher sigma-2 receptor expression and also was the most sensitive cell line evaluated to SW IV-134 PMID: 26453012
9. Study demonstrated that UII and URP binding sites are totally overlapping and that these sites were functional in regions bordering the fourth ventricle; data support a role for UII/URP at the interface between brain parenchyma and cerebrospinal fluid PMID: 24478001
10. U-II increases cytosolic Ca(2+) concentration in cardiac vagal neurons of nucleus ambiguus via 2 pathways: Ca(2+) release from the ER via INSP3 receptor; and Ca(2+) influx through P/Q-type Ca(2+) channels. PMID: 24521102
11. Hypoxia in cardiomyocytes increases UII and collagen I expression through the induction of AngII, ROS, and the JNK pathway causing cardiomyocyte hypertrophy and fibrosis. PMID: 24481965
12. The current study provides new evidence that Urotensin II (UII) is involved in the TGF-beta mediated mitogenic effect on ASMCs. UII, at least partially, uses ERK pathway to render such effect. PMID: 22270542
13. U-II and URP can differentially modulate nuclear UT functions such as gene expression, and both ligands can reach the internal cellular space through a receptor-independent mechanism PMID: 22044114
14. The expression of U II and Uts2R in right ventricle arteries and right ventricle myocytes increases significantly during the formation of pulmonary hypertension and right ventricle hypertrophy in rats chronically exposed to hypoxia-hypercapnia. PMID: 21186587
15. Transforming growth factor-beta1 involved in urotensin II-induced phenotypic differentiation of adventitial fibroblasts from rat aorta. PMID: 22166643
16. In diethylnitrosamine-induced precancerous liver lesions, the UII/UT system was up-regulated, which may contribute to the pathogenesis of liver cancer through a PKC- or ERK1/2-dependent pro-mitogenic pathway in an autocrine/paracrine manner. PMID: 21056072
17. UII infusion elevates portal pressure and induces hepatic fibrosis in normal rats. PMID: 19797237
18. In the arcuate and paraventricular nuclei, where expression is high and moderate, U-II produces a pressor/tachycardic response in the former and a weaker response in the latter PMID: 20422157
19. The expression of urotensin 2 is increased in airways of rat asthmatic models and of patients with asthma. PMID: 17045018
20. The plasma levels of urotensin II, NO, and C-type natriuretic peptide in rats with hypoxia-induced pulmonary hypertension were higher than those in the control group. PMID: 16677483
21. The results obtained indicate that U-II may exert its effects as a neuromodulator in chromaffin cells. PMID: 20025629
22. investigation of role of U-II in intimal hyperplasia after vascular injury during balloon angioplasty in thoracic aorta model: upregulation of U-II receptor, increased collagen accumulation, increased cell proliferation PMID: 19930425
23. These results suggest that the U-II and UT play an important role in the diabetic angiopathy especially in the large artery and maybe imply a new way to prevent the injury of artery in diabetes type 2 PMID: 19906507
24. the ERK and Rho kinase pathways, but not the PI3 pathway, may be involved in the central pressor action of urotensin II in conscious rats. PMID: 15097239
25. UII plays a role in the regulation of REM sleep independently of its cerebrovascular actions by directly activating cholinergic brainstem neurons PMID: 15944374
26. These findings demonstrate upregulation of UII following balloon angioplasty, and a significant reduction in intimal lesion in response to UT receptor blockade. PMID: 16171813
27. Real-time PCR demonstrated the expression of UII and UT-R mRNAs in both dispersed and in vitro cultured rat adrenocortical cells. PMID: 16685423
28. UII may also play a role in renal disease, being elevated in the circulation or urine of patients with renal failure and in experimental models of cardiovascular disease such as the spontaneously hypertensive rat. PMID: 16807543
29. Urotensin 2 is a species-form-specific coronary vasodilator. PMID: 17097764
30. Data suggest that urotensin II and urotensin II-related peptide reduce cardiac ischemia-reperfusion injury by increasing flow through the coronary circulation, reducing contractility and energy demand, and inhibiting reperfusion myocardial damage. PMID: 17900760
31. Urotensin II expression is significantly enhanced in the myocardium of rats with diabetes in both mRNA and protein levels. PMID: 18280445
32. mediator of splanchnic vasodilation, portal hypertension and renal sodium retention in cirrhotic bile duct-ligated rats PMID: 18318439
33. Data suggest that functional interaction between urotensin II and GABA(A) receptors negatively regulates coupling of UT to the classical PLC/IP(3) signaling cascade as well as to the adenylyl cyclase/PKA pathway. PMID: 18355946
34. may stimulate adventitial fibroblasts phenotypic conversion, migration, and collagen I synthesis through the protein kinase C, mitogen-activated protein kinase, calcineurin, Rho kinase, and/or Ca2+ signal transduction pathways PMID: 18475149
35. Diabetes-induced upregulation of urotensin 2 and GPR14, most likely through autocrine and/or paracrine mechanisms, plays an important role in TGF-beta1-mediated renal fibrosis and dysfunction. PMID: 18796544
36. UII may act as an autocrine/paracrine factor through its receptor and the Ca(2+) channel, protein kinase C, and mitogen-activated protein kinase signal transduction pathways, in the pathogenesis of vascular remodeling by activating vascular adventitia. PMID: 18955090
37. The gene expression of the UII system in the heart and aortae may have certain pathophysiological roles in hypertension. PMID: 19463745

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KEGG: rno:29180

STRING: 10116.ENSRNOP00000024798

UniGene: Rn.48886