NPPA Antibody

Code CSB-RA016020A0HU
Size US$350
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Product Details

Uniprot No. P01160
Target Names NPPA
Alternative Names ANF antibody; ANF_HUMAN antibody; ANP antibody; ATFB6 antibody; Atrial natriuretic factor antibody; Atrial natriuretic peptide antibody; Atriopeptin antibody; Cardiodilatin antibody; Cardiodilatin related peptide antibody; Cardiodilatin-related peptide antibody; Cardionatrin antibody; CDD ANF antibody; CDD antibody; CDD-ANF antibody; CDP antibody; Natriuretic peptide A antibody; Natriuretic peptide precursor A antibody; NPPA antibody; PND antibody; Prepronatriodilatin antibody
Species Reactivity Human
Immunogen A synthesized peptide derived from human NPPA
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Monoclonal
Isotype Rabbit IgG
Purification Method Affinity-chromatography
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Gene References into Functions
  1. platelet aggregation resulted to be higher in patients with atrial fibrillation carrying the C2238 ANP gene variant with respect to non-carriers. In conclusions, C2238/alphaANP promotes platelet aggregation through the activation of Nox2 and the reduction of cAMP. PMID: 28630469
  2. The results of our study demonstrated that the effect of NPPA SNPs rs5063 and rs198358 on central obesity might be modified by smoking in the Chinese Han population. PMID: 30262711
  3. Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. (Review) PMID: 29302701
  4. Suggest that pro-ANP/corin/NPR-C signaling is dominant in the vascular system in preeclampsia. PMID: 29523263
  5. Data indicate the blood pressure-lowering effect of atrial natriuretic peptide (ANP) in the general population. PMID: 29237677
  6. Low circulating MR-proANP at the time of device implantation is associated with cardiac resynchronization therapy response and more favourable outcome. PMID: 28096288
  7. An increase in year-by-year BP variability over the past 6 years is associated with elevated plasma levels of ANP and BNP in the Japanese general population. PMID: 28252040
  8. High plasma levels of MR-proANP are associated with the incidence of atrial fibrillation and stroke in the middle-aged and elderly population. PMID: 28195503
  9. The young adults displayed significant negative associations between MR-proANP and several components of the metabolic syndrome, whereas such associations were not found among the adolescents besides triglycerides and diastolic BP. PMID: 28338810
  10. In summary, there were no significant differences in ANP and BNP levels after percutaneous epicardial left atrial appendage suture ligation using LARIAT device 3 months after procedure. PMID: 28456775
  11. NPPA SNPs were not associated with insulin resistance in older adults. PMID: 27101535
  12. TIMP-4, NT-proANP, NT-proBNP were strongest associated with PAF and AHRE. The discriminatory performance of CHADS2-VASc for PAF was increased by addition of selected biomarkers. PMID: 28431065
  13. the G allele of the genetic variant rs5068 in African Americans is associated with lower prevalence of metabolic syndrome and lower triglycerides values PMID: 29253899
  14. ANP inhibits TGF-beta1-induced EMT in 16HBE-14o and A549 cells through cGMP/PKG signaling, by which it targets TGF-beta1/Smad3 via attenuating phosphorylation of Smad3. These findings suggest the potential of ANP in the treatment on pulmonary diseases with airway remodeling. PMID: 28229930
  15. the ANP T1766C gene polymorphism may be associated with the risk of essential hypertension, and the 1766C allele may be a protective factor against the disease PMID: 27136577
  16. increased plasma proANP should be a protective factor of hyperuricemia among middle-aged and old women PMID: 28076299
  17. Midregional-proANP could accurately detect HF in children and adolescents. Its diagnostic performance was comparable with that of NT-proBNP, regardless of the underlying condition. PMID: 27220692
  18. Corin and atrial natriuretic peptide A were most abundant in the proximal convoluted tubules and the medullary connecting ducts. PMID: 27343265
  19. This study indicates that in children with community-acquired pneumonia, sTREM-1, Midregional-proANP, and Midregional-proADM blood levels have poor abilities to differentiate bacterial from viral diseases or to identify severe cases. PMID: 27846213
  20. Higher levels of PCT, a marker of infection, and MRproANP, a marker for hemodynamic stress, were independently associated with ischemic stroke risk. PCT was specifically associated with small vessel and MRproANP with cardioembolic stroke risk. PMID: 27197849
  21. The present results demonstrate that C2238/ANP-minor allele carrier status is an independent risk factor for acute coronary syndromes recurrence in an Italian cohort of ischemic heart disease patients over the long term, and they support the role of C2238/ANP-minor allele as a negative prognostic factor in coronary artery disease patients. PMID: 25252038
  22. Both NT-proANP and NT-proBNP levels were higher in coronary artery disease patients experiencing MACEs following percutaneous coronary intervention in a non-primary setting. Notably, only NT-proANP levels significantly affected prognosis after PCI. PMID: 26987266
  23. As a risk factor, ANP gene polymorphisms may affect hypertension. Despite the small sample size in this study, it is the first research assessing the ANP gene polymorphisms in both Essential Hypertensive and Type 2 Diabetes Mellitus patients among Malaysian population. PMID: 27413750
  24. The NPPA and NPPB gene polymorphisms are associated with blood pressure in newborns. PMID: 25371308
  25. A panel of three biomarkers (MR-proANP, PCT, and MR-proADM) in patients presenting to the emergency unit with acute dyspnea provides information about the probability of acute heart failure, nonsurvival, and pneumonia. PMID: 26748496
  26. anti-inflammatory and immunomodulatory effect on IL-1beta release and on NF-kB/NALP3/caspase-1 activation PMID: 26616294
  27. prevalence of p.(Ser64Arg) mutation is low in the general population as is the prevalence of atrial fibrillation in mutation carriers PMID: 26200358
  28. Gene polymorphism of ANP (2238T>C) may be associated with developing preeclampsia during pregnancy. PMID: 26686590
  29. C2238/alphaANP downregulates ApoE in vascular smooth muscle cells through type C natriuretic peptide receptor-dependent activation of Egr-1 and the consequent upregulation of miR199a. PMID: 26720342
  30. ANP levels rose steeply after paroxysmal supraventricular tachycardia and then reduced at 30 min after the termination. PMID: 26801306
  31. Age-related elevation of plasma ANP levels preceded the development of CKD in the general population of Japan, raising a possibility for ANP being involved in the development of CKD. PMID: 26499263
  32. N-terminal pro-brain natriuretic PMID: 26244664
  33. Plasma MR-proANP independently predicts all-cause mortality and MACE in patients with STEMI. PMID: 24906365
  34. The C2238/alphaANP variant is a negative modulator of both viability and function of coronary artery smooth muscle cells. PMID: 25401746
  35. Circulating atrial natriuretic peptide genetic association study identifies a novel gene cluster associated with stroke in whites. PMID: 25452597
  36. In this review, we discuss the role of ANP in cardiovascular biology and disease. PMID: 26074089
  37. Our results suggest that the down-regulation of ANP gene expression at mRNA and protein levels and up-regulated CYP11B2 protein expression levels may be correlated with the essential hypertension PMID: 25917967
  38. study to characterize in-depth the cardiovascular and metabolic phenotype associated with rs5068 in a cohort of heart failure patients PMID: 25129277
  39. Three NPPA-NPPB polymorphisms (rs632793, rs198388 and rs198389) were associated with reduced risk of left ventricular dysfunction in CAD patients with hyperlipidemia. PMID: 25400811
  40. plasma mid-regional pro-atrial natriuretic peptide helps predict pre-eclampsia PMID: 24853905
  41. ANP is present in chondrocytes in all the three zones of the articular cartilage, sugesting that ANP may play a role in cartilage metabolism. PMID: 25864764
  42. ANP prevents cancer metastasis by inhibiting the adhesion of tumor cells to inflamed endothelial cells PMID: 25775533
  43. the contribution of ANP in different aspect of innate as well as adaptive immunity also with respect to the excessive cell growth in physiological and/or pathological conditions. PMID: 24973596
  44. NPPA acts on the NPR1 receptor, is expressed in human dorsal root and trigeminal ganglia, and the spinal cord. PMID: 25123163
  45. Elevated levels of NPPA but not of proANP or ANP proteins in left ventricular tissue, may be due to posttranscripcional regulation of NPPA or different pathways for ANP secretion between the atrium and ventricle during heart failure. PMID: 24599027
  46. the ANP genetic polymorphism and serum ANP levels could be potential biomarkers for early detection of ischemic stroke PMID: 24654911
  47. Presence of the rs5065 Atrial natriuretic peptide gene polymorphism is associated with reduced risk of the presence and severity of Coronary artery disease in an Iranian population, independent of the general risk factors of Coronary artery disease. PMID: 24487939
  48. Plasma ANP level was elevated in individuals with sleep disordered breathing among a large Japanese urban population. PMID: 24673969
  49. found a significant negative association between patients' ANP plasma concentrations and anxiety, craving for alcohol and perceived stress. PMID: 24166646
  50. CT-proAVP and MR-proANP have a significant correlation to surrogate markers of the post-cardiac arrest syndrome PMID: 24617620
  51. Carriers of at least one copy of the G allele of rs5068 in NPPA had lower likelihood of incident diabetes within 14 years. PMID: 24586593
  52. The findings suggest that the NPPA rs5068, or genetic variants in linkage disequilibrium, might affect susceptibility to left ventricular hypertrophy and support the possible protective role of natriuretic peptides. PMID: 23799939
  53. Increases in plasma ANP were related to changes in body composition induced by liraglutide in diabetic obese patients. PMID: 24498905
  54. Serum levels of ANP decreased during the treatment protocol for hypoplastic left heart syndrome. PMID: 24101702
  55. Elevated levels of atrial natriuretic factor levels at baseline predicted atrial fibrillation during a follow-up time of 16 years. PMID: 24315351
  56. the G allele of rs5068 is associated with lower blood pressure, BMI, and prevalence of hypertension and metabolic syndrome in a Mediterranean population PMID: 23637347
  57. Heart failure patients with central sleep apnea had higher ANP concentrations. ANP was inversely related to leptin concentration. PMID: 24030529
  58. Serum long-acting natriuretic peptide concentrations correlate positively with ankle-brachial index values among the kidney transplant patients. PMID: 23905909
  59. Data indicate that an 'aggregation-prone' heptapeptide ((114)KLRALLT(120)) was located within the N-terminal pro-atrial natriuretic peptide (NT-proANP) sequence. PMID: 24220659
  60. NT-proANP and NT-proBNP are powerful markers of 30-day-mortality in patients with acute heart failure of ischemic and non-ischemic origins. PMID: 23542086
  61. Atrial natriuretic peptide (ANP) is present in both human fetal and adult parotid gland. PMID: 23690218
  62. The minor allele of ANP, rs5065, was associated with increased cardiovascular risk. PMID: 24041948
  63. MiR-425 silences NPPA mRNA in an allele-specific manner. PMID: 23867623
  64. Results suggest the possibility of a relationship between plasma ANP levels and heart rate variability, which reflects autonomic activity. PMID: 22370591
  65. Daily walking activity independently predicts levels of circulating MRproANP and MRproADM in stable chronic obstructive pulmonary disease patients. PMID: 23258247
  66. Autosomal recessive atrial dilated cardiomyopathy is associated with homozygous mutation of the Natriuretic Peptide. Precursor A gene PMID: 23275345
  67. ANP increases in left ventricular volume overload irrespective of heart failure etiology. It can differentiate children in quiescent state from those in clinical failure even in the absence of echocardiographically detectable systolic dysfunction. PMID: 23279037
  68. Mid regional-proANP showed a high diagnostic accuracy for heart failure in dyspnea patients. PMID: 22981931
  69. Characterize an estradiol-regulated interaction of NPPA with ERalpha in cardiomyocytes. PMID: 22962310
  70. Based on these results above, we raise the hypothesis that ANP is involved in mediating dexamethasone's inhibition of proliferation in MM cells, which suggests that ANP may be a potential agent to treat MM. PMID: 22595807
  71. The atrial natriuretic peptide rs5065 (2238T>C) C allele seems to exert a protective effect against coronary artery disease in type 2 diabetes patients of African descent. PMID: 22170009
  72. association between frequent nonsynonymous variant of NPPA and cardioembolic stroke PMID: 22400494
  73. The minor allele of rs5065 atrial natriuretic peptide gene variant associates with increased susceptibility to acute coronary syndrome and has unfavorable prognostic value in coronary artery disease. PMID: 22575314
  74. Plasma concentrations of all proendothelin-1, proBNP, and proANP increased on average 2- to 5-fold from birth to day 2-3 of life. The plasma concentrations of all 3 propeptides increased on average 2- to 5-fold from birth to day 2-3 of life. PMID: 21952518
  75. hnRNP A1 is preferentially phosphorylated by atrial natriuretic peptide signaling which leads to co-localization of cGMP kinase and hnRNP A1 to the nucleus. PMID: 22285803
  76. These findings indicate that endothelin-1 interacts with HANP and BNP in patients with chronic congestive heart failure. Endothelin-1 is suggested to play an important role in chronic congestive heart failure with preserved ejection fraction. PMID: 22113444
  77. Study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting that preeclampsia is associated with cardiovascular changes in early pregnancy. PMID: 21741108
  78. Low plasma levels of ANP predict development of future diabetes and glucose progression over time, suggesting a causal role of ANP deficiency in diabetes development. PMID: 22112816
  79. Continuous infusion of low-dose human atrial natriuretic peptide during lung cancer surgery prevented postoperative atrial fibrillation after pulmonary resection in patients with preoperative elevation of B-type natriuretic peptide levels. PMID: 21992849
  80. Higher circulating aldosterone and lower NT-ANP concentrations may be markers of salt sensitivity in the community. PMID: 21450637
  81. Letter: report significant contributory role of NT-proANP to PAI-1 levels in adult Italian males. PMID: 21689370
  82. Granulosa luteinized cells (GLC) are the local source of ANP in the preovulatory follicle; ANP acts as a survival factor for GLC through cGMP signaling pathways. PMID: 21349128
  83. proANP and NT-proBNP levels in intrauterine growth-restricted fetuses with absent and reversed end-diastolic flow of the umbilical artery in relation to ductus venosus flow velocities PMID: 21892902
  84. Infusion of hANP during coronary artery bypass grafting in patients with chronic kidney disease improves perioperative renal function and prevents the progression of CKD. PMID: 21881323
  85. Myocardial protective effect of human atrial natriuretic Peptide in cardiac surgery. -hANP Shot" in clinical safety trial PMID: 21757823
  86. Comparison of atrial and brain natriuretic peptide for the assessment of mitral stenosis. PMID: 21600847
  87. The present results implicate miRs in nitric oxide and atrial natriuretic peptide signaling in general and miR-21 in particular in cGMP signaling and vascular smooth muscle cell relaxation. PMID: 21734186
  88. Increasing serum ANP concentrations are independently associated with hyponatremia resulting in delayed ischemic neurological deficit after aneurysmal subarachnoid hemorrhage. PMID: 20680650
  89. the minor allele of rs5068 is associated with a favorable cardiometabolic profile PMID: 21798427
  90. These results show that ANP regulates lipid catabolism and enhances energy dissipation through AMPK activation in human adipocytes. PMID: 21672517
  91. Midregional-proANP serves as a novel marker of myocardial fibrosis assessed by late gadolinium magnetic resonance imaging in patients with hypertrophic cardiomyopathy. PMID: 20872251
  92. brain-natriuretic peptide may have a role in predicts cirrhotic cardiomyopathy in liver transplant patients PMID: 21276088
  93. Mid-regional pro-adrenomedullin and mid-regional pro-atrial natriuretic peptide were shown to be associated with all-cause and cardiovascular disease mortality. PMID: 21408188
  94. pro-atrial natriuretic peptide and procalcitonin have roles in survival in ventilator-associated pneumonia PMID: 20530040
  95. Data suggest that there may be patients for whom low corin levels and impaired pro-ANP cleavage contribute to acute decompensated heart failure. PMID: 21216831
  96. Carriers of ANP precursor gene alleles that are supposed to be low functional alleles excreted more potassium on hydrochlorothiazide intake than did carriers of the higher functional alleles. PMID: 19141362
  97. Up-regulation of ANP, BNP and D-dimer predict right ventricular dysfunction in patients with acute pulmonary embolism. PMID: 20726994
  98. In chronic heart failure (CHF), tumor necrosis factor-alpha is closely related to brain natriuretic peptide and ANF(independently of CHF severity and ventricular dysfunction), particularly in patients with cardiac cachexia. PMID: 19155075
  99. In normal prostate, ANP is localized in glands as well as in stromal cells, so that ANP may have a role in regulating the composition of prostatic fluid as well as that of muscular tissue fluidity. [review] PMID: 21073007
  100. Common non-synonymous genetic variants within NPPA in two large North American cohorts of European ancestry are not associated with the development of atrial fibrillation PMID: 20543198

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Involvement in disease Atrial standstill 2 (ATRST2); Atrial fibrillation, familial, 6 (ATFB6)
Subcellular Location Secreted
Protein Families Natriuretic peptide family
Database Links

HGNC: 7939

OMIM: 108780

KEGG: hsa:4878

STRING: 9606.ENSP00000365663

UniGene: Hs.75640

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