NPPA Antibody

Datasheet
Code CSB-RA016020A0HU
Size US$350
Uniprot No. P01160
Immunogen A synthesized peptide derived from human NPPA
Species Reactivity Human
Tested Applications ELISA
Relevance Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
Alias Natriuretic peptides A, CDD-ANF, Cardiodilatin, CDD, Cardiodilatin-related peptide, CDP, Prepronatriodilatin, Atrial natriuretic factor, ANF, Atrial natriuretic peptide, ANP, NPPA, ANP, PND
Immunogen Species Human
Protocols ELISA Protocol
Research Area Cardiovascular
Gene Names NPPA
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Involvement in disease Atrial standstill 2 (ATRST2); Atrial fibrillation, familial, 6 (ATFB6)
Subcellular Location Secreted
Protein Families Natriuretic peptide family
Database Links

HGNC: 7939

OMIM: 108780

KEGG: hsa:4878

STRING: 9606.ENSP00000365663

UniGene: Hs.75640

Pathway HIF-1 signaling pathway

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