Code | CSB-RA159561A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
IP | 1:200-1:1000 |
SUZ12 is a core component of the PRC2 complex that plays an essential role in PRC2-mediated gene silencing by producing trimethylation on H3K27me3. SUZ12 is rarely expressed in normal tissues, but amplification and overexpression of SUZ12 have been detected in several solid malignancies including ovarian, colorectal, and breast cancer. Its abnormal overexpression is commonly related to tumor aggressive behaviors like enhanced proliferation, invasion, and metastasis, as well as advanced clinicopathological characteristics, and reduced survival. SUZ12 has also been shown to play a role in the cell cycle and X chromosome inactivation.
The main steps in the production of this SUZ12 recombinant antibody include immunization; harvest of positive spleen cells; obtaining the antibody sequence by screening and sequencing; expression of the target antibody in mammalian cells; purification. The SUZ12 antibody was produced recombinantly and has many advantages: high reproducibility, specificity and scalability. And has been validated in ELISA, WB, IHC, IP.There are currently no reviews for this product.