Recombinant Bovine Claudin-15(CLDN15)

Code CSB-CF646541BO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names CLDN15
Uniprot No. Q2KIY2
Alternative Names CLDN15; Claudin-15
Species Bos taurus (Bovine)
Expression Region 1-235
Target Protein Sequence MLVAVEIFGFFLTAVGLLMLGVTLAHSSWRVSTVHGNVITTNTIFENLWYSCATDSMGVH NCWEFPSMLALSGYIQACRALMITAILLGFLGLFLGMVGLRCTNIGGLELSRKTKLAATA GALHILAGICGMVAVSWYAFNITRDFFNPLYAGTKYELGPALYLGWSACLLAILGGICLF SNCCCSRDRDPATGVQLPYKAPVIPAASLAARLPAAASDEEGDSSFGKYGKNAYV
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake.
Subcellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein Families Claudin family
Database Links

KEGG: bta:514998

STRING: 9913.ENSBTAP00000000450

UniGene: Bt.59981

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Address
7505 Fannin St Ste 610-322 Houston, TX 77054, USA
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