Recombinant Bovine Diacylglycerol O-acyltransferase 1 (DGAT1)

1. the effects of dietary linseed oil, DGAT1, and the interaction between dietary linseed oil and DGAT1 on CH4 and H2 emission, energy and N metabolism, lactation performance, ruminal fermentation, and rumen bacterial and archaeal composition of dairy cows PMID: 28918153
2. Here, the association between DGAT1 K232A, SCD1 A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. The most frequent variants for DGAT1, SCD1, and LEPR polymorphisms were GC/GC, C, and C, respectively. The DGAT1 GC/GC allele was associated with lower milk fat and protein content, lower saturated fatty acid levels, and higher polyunsaturated FA PMID: 27173340
3. study showed that the DGAT1 K232A polymorphism has major effects on FA and mineral composition of bovine milk; effects are relevant in relation to cow health, human health, and functional properties of milk fat and milk protein PMID: 26898284
4. Association of a novel mutation in DGAT1 that may be responsible for unsaturated milk fat in cattle. PMID: 25719731
5. An effect of DGAT1 identified on subcutaneous fat thickness. PMID: 25414103
6. Russian and Kazakh populations of the Kazakh white-headed breed were characterized by a high content of the AA genotype of RORC (0.713 and 0.608, respectively) and of the AA genotype of DGAT1 (0.913 and 0.975) PMID: 25975152
7. Studied the occurrence of the DGAT1 p.Lys232Ala polymorphism in Romanian Holstein cattle and Romanian Buffalo breeds and further investigated its possible influence on fat percentage and fatty acid profiles. PMID: 25380462
8. Novel SNPs and INDEL polymorphism in DGAT1 are associated with milk production and protein and fat milk composition. PMID: 24676595
9. Single nucleotide polymorphisms in the DGAT1 gene significantly effected fat distribution in Chinese commercial cattle. PMID: 23143182
10. effects of K232A polymorphism on milk fat composition in winter and summer PMID: 23127906
11. results indicated that knockdown of DGAT1 expression significantly reduced triglyceride content in bovine mammary epithelial cells PMID: 23539897
12. The use of leptin, leptin receptor, and DGAT1 polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters. PMID: 22127264
13. pleiotropic effects of polymorphism Ala to Lys amino acid substitution at position 232 in mammary gland tissue PMID: 22916903
14. The impact of different alleles of DGAT1 and leptin on milk production in Giorlando cattle is reported. PMID: 21396671
15. Genotype KK has the greatest effect on all milk composition content traits, while genotype AA has the greatest effect on yield traits. It can be concluded that the DGAT1 gene can be used as a gene marker for assisted selection in milk composition traits. PMID: 21881942
16. No differential allelic expression was observed for the DGAT1 genes in bovine fetal tissues. PMID: 21899958
17. The present study investigated putative interaction effects between the DGAT1 K232A mutation and the polygenic term (i.e., all genes except DGAT1) for 5 milk production traits in the German Holstein dairy cattle population. PMID: 21338826
18. The K232A substitution of the DGAT1 gene could be used as a golden standard in comparisons of the effect on milk productivity for the total gene set. PMID: 21446190
19. The results confirm the lack of an association found by many other studies and suggest that these SNPs are not influential on the divergent intramuscular fat levels in the crossbred population tested. PMID: 20416823
20. Effects of the DGAT1 p.Lys232Ala on milk, fat and protein yield, as well as fat and protein percentage in the milk of 1222 Holstein cows showed DGAT1 allele that encode lysine at position 232 was associated with increased 305-day milk fat yield. PMID: 19781040
21. The effects of an amino acid substitution in DGAT1 on milk yield in Holstein cattle, and its frequency in North American cattle, are reported. PMID: 20379885
22. DGAT1 polymorphism had the strongest association with milk FA composition, which confirmed the key role of DGAT1 in lipid metabolism of mammary gland PMID: 20105547
23. results suggested a potential effect of the DGAT1 polymorphism on nonreturn rates for insemination 28 and 56 d after the first service PMID: 19841232
24. K allele, causing an increase in milk fat percentage in the live animal, is characterized by a higher Vmax in producing triglycerides than the A allele. PMID: 14983021
25. examined and characterized the occurrance of the K232A substitution in the DGAT1 gene in Bos taurus and Bos indicus PMID: 15190946
26. Variation in the number of tandem repeats of the 18mer element might be causal for the variability in the transcription level of the DGAT1 gene. PMID: 15342525
27. DGAT1 found to have greatest additive effect on subcutaneous fat thickness in beef cattle after Bayesian model selection analysis of 5 candidate genes PMID: 16175458
28. associated with increased fat yield, fat and protein percent as well as decrease in milk yield; also in Bos indicus and Bubalus bubalis PMID: 17087837
29. A simultaneous analysis of the influence of CYP11B1 and DGAT1 on multiple variables of a German Holstein pedigree is presented. PMID: 17179535
30. characterization of both the VNTR and the K232A polymorphisms in the DGAT1 gene in the 3 main French dairy cattle breeds PMID: 17517739
31. The SNP (C/T) detected at position 11785 in exon 17 creates a substitution change for the amino acid sequence, resulting in an Ala residue (GCG) transition to a Val residue (GTG) in position 484 of buffalo DGAT1 protein. PMID: 17592768
32. we identified differences in the magnitude of effects between paternally and maternally inherited DGAT1 promoter VNTR - K232A haplotypes indicating parent-of-origin effects on milk production traits PMID: 17892573
33. K232A polymorphism has a clear influence on milk-fat composition. PMID: 17894561
34. bovine Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism effects were found for fat and protein percentages and milk yield PMID: 18420644
35. conclude that selective breeding can contribute to higher unsaturation indices, and that selective breeding can capitalize on genotypic information of both stearoyl-CoA desaturase (SCD1)and diacylglycerol O-acyltransferase homolog 1(DGAT1)polymorphism PMID: 18420645
36. single nucleotide polymorphisms in Diacylglycerol acyltransferase had a significant effect on milk yield PMID: 18650297
37. DGAT1 and growth hormone receptor alleles whichor increase in milk production were found to have an adverse effect on reproduction, while the leptin allele responsible for increase in milk production was linked to marginally increased metritis frequency. PMID: 18822099

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KEGG: bta:282609

STRING: 9913.ENSBTAP00000037256

UniGene: Bt.61989