Recombinant Human OX-2 membrane glycoprotein(CD200)

Code CSB-CF004895HU
Size Pls inquire other sizes
Source in vitro E.coli expression system
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Product Details

Target Names CD200
Uniprot No. P41217
Alternative Names Antigen identified by monoclonal MRC OX 2; CD200; CD200 antigen; CD200 molecule; MOX1; MOX2; MRC; MRC OX 2 antigen; My033; OX 2; OX 2 membrane glycoprotein precursor; OX-2 membrane glycoprotein; OX2G; OX2G_HUMAN
Species Homo sapiens (Human)
Expression Region 31-278
Target Protein Sequence QVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVNKGYWFSVPLLLSIVSLVILLVLISILLYWKRHRNQDRGELSQGVQKMT
Protein Length full length protein
Tag Info The following tags are available.
N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Gene References into Functions
  1. overexpression of human CD200 in donor pigs could constitute a promising strategy for overcoming xenograft rejection. PMID: 28968355
  2. Our results support the fact that CD200 can be added to routine Chronic lymphoproliferative disorders panel as it is useful in subcategorizing them. However, inclusion of CD20 ABC to routine panel does not seem plausible but may be done for difficult diagnostic cases or where anti-CD20 therapy is planned. PMID: 29567884
  3. A diligent morphological examination to look for the presence of hairy cells along with flow cytometric immunophenotyping showing consistent bright expression of CD200, in addition to well-described characteristic immunophenotype, helps in correctly diagnosing the case. This can be further confirmed by the consistent presence of V600E point mutation in BRAF gene. PMID: 30197362
  4. CD200(+) and/or CD56(+) positive expression in B-ALL patients at diagnosis is a poor prognostic biomarker. PMID: 29161980
  5. CD200 was expressed in 97.3% of atypical chronic lymphocytic leukemia cases, whereas it was dimly expressed in only 6.1% of mantle cell lymphoma cases. PMID: 28713070
  6. CD200 and/or CD56 positive expression in B-ALL at diagnosis suggest a poor prognosis and may be associated with biological aggressiveness. PMID: 29144828
  7. downregulation of CD200 expression resulted in an imbalance of increased Th1 cytokine and decreased Th2 cytokine production in placental trophoblasts in preeclampsia PMID: 28940677
  8. This is the first report of CD200 mRNA and protein expression in patients with transitional cell carcinoma of the human bladder. TCC tissues showed significantly higher CD200 expression than normal bladder tissues. CD200 signals were also higher in metastasized compared to localized TCC. The data provide a strong indication for a putative role of CD200 in the immune-evasion of bladder cancer. PMID: 29715095
  9. Our data confirm a negative impact of ABCG2 and CD200 overexpression also in AML patients considered at favorable risk according to ELN cytogenetic/molecular classification. PMID: 28618016
  10. Residual CD200 activity may prevent completion of abortions via induction of Treg cells. In chronic histiocytic intervillositis, infiltrating maternal effector T cells may block Treg induction. An autocrine role for CD200-CD200R interaction versus inhibition of soluble CD200 by soluble CD200R is discussed. PMID: 28326648
  11. patients with Autosomal dominant polycystic kidney disease have activated soluble CD200 levels which were related to renal function and inflammation. PMID: 28179401
  12. correlation of sCD200 serum levels with COPD-related parameters in humans with established disease revealed that the CD200/CD200R axis may be mechanistically linked to the disease course in COPD patients. PMID: 27864635
  13. It suppresses macrophage-mediated xenogeneic cytotoxicity and phagocytosis. PMID: 28573328
  14. High expression of CD200 is associated with chronic lymphocytic leukemia. PMID: 26910908
  15. It is a anti-inflammatory protein. PMID: 28390825
  16. CD200 expression therefore may be used to help identify pulmonary small cell carcinoma in flow cytometry specimens. PMID: 26584149
  17. Our data suggest a negative impact of CD200 expression in cytogenetically-normal acute myeloid leukemia PMID: 28407515
  18. CD200 was expressed in 87% of the neuroendocrine neoplasms studied. CD200 is a relatively sensitive marker of neuroendocrine neoplasms and represents a potential therapeutic target in these difficult-to-treat malignancies. PMID: 28821198
  19. Up-regulation of CD200 in MDS predicts poor prognosis. PMID: 28152413
  20. this study shows that that CD200 suppresses the immune system's response to vaccines, and that blocking CD200 could improve the efficacy of cancer immunotherapy PMID: 27485078
  21. These results suggest that CD200S activates TAMs to become DC-like antigen presenting cells, leading to the activation of CD8(+) cytotoxic T lymphocytes, which induce apoptotic elimination of tumor cells. PMID: 27108386
  22. increased expression of CD200, expansion of suppressive Treg cells and elevation of cytokines might have a role in multiple myeloma progression PMID: 26033514
  23. In the present study, we showed for the first time a correlation between CD200 expression and the Wnt signaling pathway in colon cancer cells. PMID: 27574016
  24. data confirms that a functionally active CD200 extracellular moiety can be cleaved from the surface of CD200 expressing cells following ectodomain shedding PMID: 27111430
  25. CD200 is a poor prognostic factor for overall survival in multiple myeloma (MM) patients. Bone marrow CD3 lymphocytes from MM patients express CD200 protein in higher proportion than healthy donors. PMID: 26177431
  26. CD200 expression by cultured cultured bone marrow mesenchymal stem cells can be induced by both osteogenic and pro-inflammatory cytokines through the sole NF-kappaB pathway. PMID: 26773707
  27. suggest that microglial activation may be partially caused by CD47/signal regulatory protein-alpha- and CD200/CD200R-mediated reductions in the immune inhibitory pathways PMID: 27095555
  28. CD200 is up-regulated and may be a novel biomarker for the prognosis in cutaneous squamous cell carcinoma. PMID: 27035797
  29. CD200 expression is a useful marker for evaluation of the severity of PCM and that lack of CD200 expression may improve the sensitivity of PCM to therapy with new drugs. PMID: 26763359
  30. the combination of CD200 and CD148 may have a potential differential diagnostic value in leukemic B-CLPDs, especially between CLL and MCL. PMID: 25791119
  31. CD200-CD200R1 signaling may be required for human pregnancy success. PMID: 26123445
  32. CD200 signaling may play a key role in regulating macrophage polarization toward anti-inflammatory phenotypes PMID: 26670206
  33. Suggest CD200 as both prognostic factor and potential therapeutic target AML, aiming to reverse the "do not eat me" signal of CD200 or to manipulate the suppressive immune microenvironment induced by CD200 binding to its receptor. PMID: 26338961
  34. CD160 and CD200 are expressed in B cells in chronic lymphocytic leukemia and are absent in other mature B-cell neoplasms. PMID: 25470765
  35. our study confirms that CD200/BTLA deletions are recurrent genetic lesions in the biology of BCP-ALL PMID: 26137961
  36. CD200 antigen expression features response for chemoradiation in patients squamous cell head and neck cancer. PMID: 24700450
  37. CD200 expression by early-stage human breast cancer cells in primary tumors did not correlate with increased regional lymph node metastasis. PMID: 25041579
  38. The proportion of CD200+ cells in PBMCs, peripheral CD14+ cells and CD4+ T cells was significantly lower in rheumatoid arthritis patients compared to controls, whereas the number of CD200+ cells was higher in synovium from RA patients than from controls. PMID: 25261692
  39. Prognostic value of CD200 detected in malignant ascites from patients with metastatic ovarian, endometrial and breast neoplasms remains to be elucidated. PMID: 25778329
  40. We demonstrate a significant correlation between CD200R1 positive cells and disease severity in rheumatoid arthritis (RA) patients, thus indicating the relevance of the CD200/CD200R1 signaling pathway potential involvement in the pathogenesis of RA. PMID: 24496593
  41. The mechanism underlying ESA might be associated with enhanced expression of CD200 and CD200R in the trophoblast, leading to an upregulation of the immune response during the first trimester of pregnancy. PMID: 25145957
  42. The results expand the understanding of the CD200 expression in mature B-cell neoplasms , giving further support for the inclusion of this marker in the routine investigation by flow cytometry. PMID: 24243815
  43. staining by flow cytometry can be useful in the differential diagnosis of B-cell neoplasms and in their detection in the bone marrow PMID: 25389338
  44. CD200 is expressed in a majority of plasma cell myeloma cases, and the expression is stable during the treatment process. PMID: 24958785
  45. The soluble OX-2 levels of type 2 diabetic foot were compared with that of healthy controls. PMID: 24964809
  46. The expression of CD200 as well as B7-H4 co-stimulatory molecules on CD14(+) cells were significantly higher in cord blood when compared with peripheral blood. PMID: 23066977
  47. Measurement of sCD200 and/or sCD200R1 may prove a useful and rapid means of monitoring subjects at risk of bone loss. PMID: 24333170
  48. expression of CD200 in the bone marrow of chronic lymphocytic leukemia PMID: 24405602
  49. [review] Inhibitory receptors are separated into two major classes based on their extracellular domains: immunoglobulin (Ig) and carbohydrate-binding C-type lectin families. PMID: 24388216
  50. Soluble CD200 might play a role in immune response in the pathogenesis of autoimmune and inflammatory skin disorders. PMID: 24157657
  51. Mesenchymal stem cells, through the expression of CD200, play a major role in the regulation of bone resorption and bone physiology and the CD200-CD200R couple could be a new target to control bone diseases. PMID: 23940819
  52. Elevated amniotic fluid CD200 levels in the presence of funisitis suggest the involvement of negative regulatory mechanisms of innate immunity. PMID: 23489112
  53. Overall survival in non-small cell lung cancer correlated with serum CD200 levels. PMID: 24344047
  54. CD200 expression in multiple myeloma could suppress antitumor response and anti-CD200 treatment might be therapeutically beneficial in CD200-expressing tumors. PMID: 24183830
  55. Effects of omalizumab on eosinophil cationic peptide, 25-hydroxyvitamin-D, IL-1beta and sCD200 in cases of Samter's syndrome PMID: 23841472
  56. The expression of CD200 and its receptor, CD200R, on CD83+ monocyte-derived dendritic cells (Mo-DCs), pulsed or not with autologous tumor cell lysates (aTCL) in patients who suffer from laryngeal carcinoma, were examined. PMID: 23690219
  57. CD200 flow cytometric assessment and semiquantitative immunohistochemical staining distinguishes hairy cell leukemia from hairy cell leukemia-variant and other B-cell lymphoproliferative disorders. PMID: 24045551
  58. blocking CD200 on tumor cells may have opposite effects on tumor proliferation depending on the "affinity" of the macrophages to form the CD200-CD200R-complex with tumor cells. PMID: 23541619
  59. High plasma CD200 expression is associated with B-Cell Chronic Lymphocytic Leukemia. PMID: 23643150
  60. Evaluating CD200 expression has a great impact on accurate B-chronic lymphoproliferative disorders (BCLPDs) diagnosis and could be added to the BCLPD routine panels. PMID: 22064604
  61. We conclude that CD200 is a practical and useful marker for the diagnosis of primary mediastinal large B cell lymphoma. PMID: 22899296
  62. CD200 and CD200R1 expression and function are abnormal in systemic lupus erythematosus PMID: 22621248
  63. in cutaneous squamous cell carcinoma, CD200 expression on local blood vessels may promote tumor progression by suppressing CD200R myeloid cells during diapedesis PMID: 23560298
  64. data present a significant role for CD200 in suppressing anti-tumor immune response through stimulation of regulatory mechanisms in acute myeloid leukemia patients and suggest that CD200 may have a prognostic value in this malignanc PMID: 23179394
  65. Mesenchymal stromal cells are able to modulate the expression of both CD200 and CD200R on some T-cells. PMID: 22575528
  66. Findings suggest sCD200 as a novel prognostic marker and therapeutic target for chronic lymphocytic leukemia (CLL). PMID: 22875025
  67. Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells. PMID: 22430636
  68. a novel role for CD200-CD200R interaction in inhibiting tumor formation and metastasis PMID: 22319630
  69. The capacity of 1alpha,25-dihydroxyvitamin D3 to induce CD200 expression by peripheral and respiratory tract T cells identifies an additional pathway via which vitamin D can restrain inflammation in the airways to maintain respiratory health. PMID: 22334534
  70. Decreased expression of CD200 on CD1c+ myeloid dendritic cells was observed in the third trimester of normal pregnancy suggesting that tolerogenic properties of dendritic cells decrease before delivery; higher expression was observed during preeclampsia PMID: 22462561
  71. these results indicate a role of CD200R:CD200 in T cell responses to helminths which has diagnostic and prognostic relevance as a marker of infection for chronic schistosomiasis in mouse and man. PMID: 22496920
  72. The role of the CD200-CD200R axis in bone marrow-derived mesenchymal stem cell mediated immunosuppression was studied using THP-1 human macrophages. PMID: 22363701
  73. Data show that high levels of KRT15 expression correlated with a stem cell phenotype and found that KRT15hiITGA6hi stem cells were preserved in bald scalp, while distinct populations of CD200hiITGA6hi and CD34hi cells were markedly diminished. PMID: 21206086
  74. CD200 is a useful immunophenotypic marker of angioimmunoblastic T-cell lymphoma. PMID: 21164290
  75. CD200 may be a useful immunophenotypic marker in the evaluation of B cell-derived neoplasms. PMID: 20959655
  76. effect of CD200 blockade in vitro on a generation of CTL responses against a poorly immunogenic CD200+ lymphoma cell line and fresh cells obtained from CLL patients PMID: 20442224
  77. We show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-4 or IL-13. PMID: 20375636
  78. Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth. PMID: 11726033
  79. panel of mAbs to mouse and human CD200Fc to compare the rank activities of antibodies for binding (flow cytometric analysis [FACS] or enzyme-linked immunoadsorbent assay [ELISA]). PMID: 15699757
  80. revealed a 169 bp region responsible for constitutive expression of CD200; positive regulatory domains were identified in the core promoter; and documented evidence for C/EBPbeta as being important in transcriptional regulation of CD200 PMID: 15955564
  81. Human CD200 is recognized by human CD200R; the activation of basophils is down-regulated by these CD200 proteins PMID: 16177086
  82. Reactions with CD200 receptor modulate immunomodulation for prevention of undesired immune responses of the skin. PMID: 16354172
  83. Here we describe CD200 co-expression with stem cell markers found on prostate, breast, brain, and colon cancers. PMID: 17964286
  84. mutation of N-RAS or B-RAF, signature genetic lesions present in most MMs, potently induced the expression of cell-surface CD200, a repressor of DC function. PMID: 18008004
  85. Review highlights the close correlation between CD200-CD200 receptor (CD200R), microglia activation, and Parkinson's disease. PMID: 18040859
  86. melanoma, ccRCC and ovarian tumor cells can express CD200, thereby potentially suppressing anti-tumor immune responses. CD200 blockade with an antagonistic antibody may permit an effective anti-tumor immune response in these solid tumor types. PMID: 18060403
  87. Taken together, these data suggest that CD200 is a potential therapeutic target and prognostic factor for a large array of malignancies. PMID: 18060862
  88. The CD200-CD200R pathway seems of critical relevance for macrophage-mediated damage in autoimmune inflammation of the CNS. PMID: 18164423
  89. CD200 blockade was further shown to stimulate antigen-specific T cell responses towards the CLL-associated antigen fibromodulin PMID: 18838168
  90. Identification of an expressed truncated form of CD200, CD200tr, which is a physiologic antagonist of CD200-induced suppression. PMID: 18946351
  91. lower % CD200(+) cell number may also reflect hitherto unappreciated paternal factors bearing on reproductive success PMID: 19086995
  92. CD200-mediated immune suppression may occur not only via neuron-microglia interactions, but also via glia-glia interactions, especially in inflammatory conditions in which an immune-suppressive environment needs to be restored. PMID: 19151626
  93. all B-CLL cells were CD200+ both in lymph nodes and in BM while all MCL cells were negative. Adding CD200 in routine panels could be of diagnostic utility in excluding MCL diagnosis PMID: 19230971
  94. IFN-gamma and TNF-alpha induce CD200 expression through a 5' upstream enhancer and that NF-kappaB, STAT1 and IRF-1 play pivotal roles in this process. PMID: 19386363
  95. CD200 is a stem cell surface marker in human hair follicle bulge PMID: 20050020

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Subcellular Location Cell membrane, Single-pass type I membrane protein
Database Links

HGNC: 7203

OMIM: 155970

KEGG: hsa:4345

STRING: 9606.ENSP00000420298

UniGene: Hs.79015

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