Recombinant Pig Gamma-glutamyltranspeptidase 1(GGT1)

Code CSB-CF009394PI
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P20735
Storage Buffer Tris-based buffer,50% glycerol
Species Sus scrofa (Pig)
Sequence MKKRYLLLALAAVALVLLILGLCLWLPSNSKPHNHVYPRAAVAADALRCSEIGRDTLRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEIINAREVAPRLASASMFNSSEQSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIELASQGFPVGKGLAAALERSQDAIKRHPALCEVFCRNGNVLREGDLVTMPRLAKTYETLAVEGAQAFYNGSLTAQIVKDIQEAGGIVTAEDLNNYRAELIEQPLRISLGDAQLYAPNAPLSGPVLALILNILKGYNFSRASVETPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVNVTEVVRNMSSEFFADQLRARISDTTTHPDSYYEPEFYTPDDAG
Source in vitro E.coli expression system
Gene Names GGT1
Protein Names Recommended name: Gamma-glutamyltranspeptidase 1 Short name= GGT 1 EC= 2.3.2.2 Alternative name(s): Gamma-glutamyltransferase 1 Glutathione hydrolase 1 EC= 3.4.19.13 CD_antigen= CD224 Cleaved into the following 2 chains: 1. Gamma-gluta
Expression Region 1-379
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism.
Subcellular Location Cell membrane, Single-pass type II membrane protein
Protein Families Gamma-glutamyltransferase family
Tissue Specificity Highly expressed in kidney. Detected at lower levels in liver, lung, plexus choroideus and brain capillary endothelial cells.
Database Links

KEGG: ssc:397095

STRING: 9823.ENSSSCP00000028318

UniGene: Ssc.116

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