FBXO22 Antibody

Datasheet

Code	CSB-PA854115ESR2HU
Size	US$166
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Image	Western blot All lanes: FBXO22 antibody at 2.42 μg/ml Lane 1: Mouse heart tissue Lane 2: Mouse liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 45, 5, 31 kDa Observed band size: 45 kDa Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA854115ESR2HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FBXO22 Polyclonal antibody

Uniprot No.

Q8NEZ5

Target Names

FBXO22

Alternative Names

0610033L19Rik antibody; 1600016C16Rik antibody; F box only protein 22 antibody; F box protein 22 antibody; F box protein FBX22p44 antibody; F-box only protein 22 antibody; F-box protein FBX22p44 antibody; FBX22 antibody; FBX22_HUMAN antibody; FBXO 22 antibody; FBXO22 antibody; FIST domain containing 1 antibody; FISTC1 antibody; FLJ13986 antibody; MGC124731 antibody; MGC31799 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human F-box only protein 22 protein (104-403AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Gene References into Functions

Data show that FBXO22 mediated the polyubiquitination and degradation of CD147 by interacting with CD147 intracellular domain (CD147-ICD). PMID: 28117675
Authors demonstrate that F-box only protein 22 (FBXO22) interacts with and thereby destabilizes KLF4 via polyubiquitination. As a result, FBXO22 could promote HCC cells proliferation. PMID: 26087183
Results indicate that SCF(Fbxo22)-KDM4A is an E3 ubiquitin ligase that targets methylated p53 and regulates key senescent processes. PMID: 26868148
FBXO22 protein is required for optimal synthesis of NMDA receptor coagonist D-serine by interacting with serine racemase, activating it, and preventing its targeting to membranes. PMID: 25336657
we determined that the phage-encoded GogB effector protein in Salmonella targets the host SCF E3 type ubiquitin ligase through an interaction with Skp1 and the human F-box only 22 (FBXO22) protein PMID: 22761574
FBXO22 is a key regulator of histone methylation marks, namely, H3K9 and H3K36 methylation, through the regulation of KDM4A protein levels. PMID: 21768309

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Subcellular Location

Cytoplasm, myofibril, sarcomere, Z line.

Tissue Specificity

Predominantly expressed in liver, also enriched in cardiac muscle.

Database Links

HGNC: 13593

OMIM: 609096

KEGG: hsa:26263

STRING: 9606.ENSP00000307833

UniGene: Hs.591115

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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