MYBPH Antibody, FITC conjugated

Code CSB-PA618765LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MYBPH Polyclonal antibody
Uniprot No.
Target Names
MYBPH
Alternative Names
bHLHe38 antibody; H protein antibody; H-protein antibody; l-myc protein antibody; l-myc-1 proto-oncogene antibody; LMYC antibody; MyBP H antibody; MyBP-H antibody; Mybph antibody; MYBPH_HUMAN antibody; myc-related gene from lung cancer antibody; MYCL antibody; Myosin binding protein H antibody; Myosin binding protein, 86-KD antibody; Myosin-binding protein H antibody; Oncogene lmyc antibody; V-myc avian myelocytomatosis viral oncogene homolog 1, lung carcinoma derived antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Myosin-binding protein H protein (3-159AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.
Gene References into Functions
  1. variation in MYBPH can modulate the severity of hypertrophy in hypertrophic cardiomyopathy patients. PMID: 26969327
  2. MyBP-H expression signals the onset of dysregulation in actin-myosin interaction; this in turn might contribute to the pathogenesis of amyotrophic lateral sclerosis. PMID: 24184715
  3. These results suggest that MYBPH inhibits RLC and NMHC IIA, independent components of NM IIA, and negatively regulates actomyosin organization at 2 distinct steps, resulting in firm inhibition of NM IIA assembly. PMID: 23068101
  4. MYBPH inhibited assembly competence-conferring phosphorylation of the myosin regulatory light chain (RLC) as well as activating phosphorylation of LIM domain kinase, unexpectedly through its direct physical interaction with Rho kinase 1 PMID: 22085929
Protein Families
Immunoglobulin superfamily, MyBP family
Tissue Specificity
Mainly expressed in the skeletal muscle. Slightly expressed in the left atrium and arteria mammaria interna.
Database Links

HGNC: 7552

OMIM: 160795

KEGG: hsa:4608

STRING: 9606.ENSP00000255416

UniGene: Hs.927

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