Recombinant Human C-C motif chemokine 7 protein(CCL7) (Active)

1. Enzyme-linked immunosorbent assay was used to detect the levels of chemokine (C-X-C motif) ligand 12, chemokine (C-X-C motif) ligand 7, hepatocyte growth factor, and fibroblast growth factor 1 in the supernatants of the laryngeal squamous cell carcinoma and control cells. PMID: 28475003
2. Periprostatic adipocytes drive prostate cancer progression in obesity via CCL7 secretion which stimulates CCR3 expressing tumor cells. PMID: 26756352
3. These results suggest that let-7d may suppress renal cell carcinoma growth, metastasis, and tumor macrophage infiltration at least partially through targeting COL3A1 and CCL7. PMID: 25193015
4. Based on nasopharyngeal CCL7 gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants. PMID: 25261323
5. Overexpression of ISL1 in human mesnchymal stem cells promotes angiogenesis in vitro and in vivo through increasing secretion of MCP3 and other paracrine factors. PMID: 24578274
6. Our data demonstrate that the monocyte-specific chemokine CCL7 and its receptor CCR2 are expressed in tumour cells of RCC PMID: 24327013
7. Systemic IFN-gamma triggered the secretion of C-C motif ligand chemokines CCL2 and CCL7 leading to the egress of early, myeloid-committed progenitors from the bone marrow mediated by their common receptor CCR2. PMID: 23762028
8. Anticancer effect of desmethyl-lasiodiplodin is mediated, in part, by upregulation of apoptotic genes and downregulation of MCP-3. PMID: 23764760
9. Immunohistochemistry and real-time PCR analysis showed that CCL7 was expressed in normal colonic epithelium and the expression was higher in liver metastases compared to primary CRC. PMID: 22614322
10. These results suggest that overexpression of CCL21 and CCL7 is associated with tumor metastasis and serves as a prognostic factor in patients with gastric cancer. PMID: 22468089
11. MCP-3 is produced by human coronary artery smooth muscle cells and directly induces CASMC proliferation in vitro, suggesting a potential role for this chemokine in vascular pathology PMID: 21536288
12. we established, for the first time, a significant association of MCP3 variants with atopic asthma. PMID: 21388664
13. Basal monocyte migration may be facilitated by the astrocyte-derived cytokine CCL7 whose production is rapidly increased by TNF-alpha and thus likely plays a critical role in initiating neuroinvasion by SIV/HIV. PMID: 21279498
14. The expression of MCP-3 in laryngeal squamous cell carcinoma is much higher than in normal tissue. PMID: 18533557
15. IL-12 p35, ICAM-1 and MCP-3 mRNAs are expressed in primary nasal epithelial cells. PMID: 19253530
16. Cytoplasmic GR interacts with a subset of CCL7 mRNA through specific sequences and can regulate turnover rates, a novel posttranscriptional role for GR as an RNA-binding protein. PMID: 21148795
17. Monocyte chemoattractant protein-3 (MCP-3) was highly expressed in patients with chronic periodontitis, particularly in those with progressive periodontal lesions. PMID: 20151806
18. higher expression in the genital mucosa than in the blood of HIV-1-infected women from Benin PMID: 19898927
19. Elevated level of CCL7 is associated with invasion and migration of oral squamous cell carcinoma. PMID: 19937793
20. The two most abundant alleles of the CA/GA microsatellite polymorphism in the promoter-enhancer region of the MCP-3 gene, A2 and A3, are significantly associated with multiple sclerosis in the Belgian case-control study, but not in the family study. PMID: 12127674
21. overexpression of MCP-3 in early-stage systemic sclerosis suggests a novel role for this protein as a fibrotic mediator activating extracellular matrix gene expression in addition to promoting leukocyte trafficking. PMID: 12847692
22. monocyte chemotactic protein-3 uses a different mode of action from eotaxin PMID: 14733956
23. data suggest that cyclic mechanical stretch of the uterine cervix by the presenting part of the fetus during labour may augment both IL-8 and MCP-3 production in the uterine cervix via AP-1 activation. PMID: 15194816
24. These results suggest that oxLDL delivers its signal for MCP-3 expression via PPARgamma, which may be further related to the atherogenesis. PMID: 15381085
25. A non-heparin-binding mutant CCL7 inhibits chemotactic potential of synovial fluid from patients with active rheumatoid arthritis and demonstrates the glycosaminoglycan-binding requirement for chemokine-driven inflammation in vivo PMID: 16002730
26. CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
27. MCP-3 is critical for monocyte mobilization and suggests new roles for monocyte chemoattractants in leukocyte homeostasis. PMID: 17364026
28. CCL7 synergizes with coproduced CXCL8 in peripheral blood monocyte migration. PMID: 18469140
29. increased plasma levels in patients with amnestic mild cognitive impairment PMID: 19403065
30. High MCP-3 is associated with macrophage/microglia infiltration in gliomas. PMID: 19424580

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HGNC: 10634

OMIM: 158106

KEGG: hsa:6354

STRING: 9606.ENSP00000367832

UniGene: Hs.251526