CycE Antibody

1. These findings reveal a Gcm-Apt-CycE axis that regulates neuroblast and glia cell differentiation. PMID: 29625112
2. we provide genetic evidences, that the Ama-Nrt-Abl-pathway regulates CycE expression by altering the function of the Hippo effector Yorkie in embryonic NBs PMID: 27015425
3. We further detected that reduced level of GRK2 induced a small cell cycle arrest at G2/M phase by enhancing the expression of cyclin A, B1, and E PMID: 23460259
4. CycE and Cdk2 are required for germline stem cell proliferation. PMID: 23293285
5. p53-mediated regulation of ectopic neural stem cells (NSC) self-renewal through the Ago/Cyc E axis becomes particularly important when NSC homeostasis is perturbed. PMID: 22140513
6. analysis of Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system PMID: 19799999
7. The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. PMID: 20008573
8. This work provides in vivo genetic evidence for p53-mediated integration of metabolic stress signals, which modulate the activity of the ubiquitin-proteasome system to degrade cyclin E protein and thereby impose cell cycle arrest. PMID: 20176921
9. CycE inhibits the function of Prospero and facilitates its cortical localization, which is critical for inducing stem cell behaviour. PMID: 19914234
10. follicular stem cell function was substantially restored by expressing either excess DE-cadherin or excess E2F1/DP, the transcription factor normally activated by CycE-Cdk2 phosphorylation of retinoblastoma proteins PMID: 19966222
11. Brm complex mutants suppress the DmcycE(JP) phenotype by increasing S phases w/o affecting DmcycE protein levels. DmcycE physically interacts with Brm & Snr1 in vivo. The Brm complex inhibits S phase by acting downstream of DmcycE protein accumulation. PMID: 12093739
12. centrosome overduplication still occurs in skpA-; cycE- mutant animals, demonstrating that high cyclin E levels are not necessary for centrosome overduplication PMID: 12730292
13. we link the CSN to the degradation of Cyclin E, which promotes the G1-S transition in the cell cycle and then is rapidly degraded by the ubiquitin-proteasome pathway PMID: 12737805
14. asymmetric divisions are due to upregulation of Cyclin E in late ganglion mother cells PMID: 14973280
15. phosphorylation and degradation of Dup protein at G1/S requires cyclin E/CDK2 PMID: 15342466
16. string(cdc25) and cyclin E control patterned histone expression at different stages of Drosophila embryonic development. PMID: 15355790
17. critical role for CycE in regulating cell fate in segment-specific neural lineages. PMID: 15580266
18. cyclin E functions downstream of the homeotic genes largly independently of its role in proliferation PMID: 15632940
19. Cell cycle diversity involves differential regulation of Cyclin E activity in the Drosophila bristle cell lineage. PMID: 15829522
20. The most significant cyclin E alteration is post-translational cleavage of full-length cyclin E into low molecular weight forms that are hyperactive compared to the 50-kDa, full-length protein and correlate with increasing stage of breast cancer. PMID: 16637514
21. Fondue is a major hemolymph protein required for efficient clotting in Drosophila PMID: 16690050
22. APC/C-Fzr activity is periodically inhibited by CycE-Cdk2, to prevent relicensing in S-phase cells. PMID: 18559483
23. Minus contributes to cell cycle regulation in part by selectively controlling turnover of Cyclin E PMID: 19723762

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KEGG: dme:Dmel_CG3938

STRING: 7227.FBpp0294012

UniGene: Dm.3509