CycE Antibody

Code CSB-PA345801XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) CycE Polyclonal antibody
Uniprot No.
Target Names
CycE
Alternative Names
CycE antibody; CG3938 antibody; G1/S-specific cyclin-E antibody; DmCycE antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) CycE protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex.
Gene References into Functions
  1. These findings reveal a Gcm-Apt-CycE axis that regulates neuroblast and glia cell differentiation. PMID: 29625112
  2. we provide genetic evidences, that the Ama-Nrt-Abl-pathway regulates CycE expression by altering the function of the Hippo effector Yorkie in embryonic NBs PMID: 27015425
  3. We further detected that reduced level of GRK2 induced a small cell cycle arrest at G2/M phase by enhancing the expression of cyclin A, B1, and E PMID: 23460259
  4. CycE and Cdk2 are required for germline stem cell proliferation. PMID: 23293285
  5. p53-mediated regulation of ectopic neural stem cells (NSC) self-renewal through the Ago/Cyc E axis becomes particularly important when NSC homeostasis is perturbed. PMID: 22140513
  6. analysis of Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system PMID: 19799999
  7. The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. PMID: 20008573
  8. This work provides in vivo genetic evidence for p53-mediated integration of metabolic stress signals, which modulate the activity of the ubiquitin-proteasome system to degrade cyclin E protein and thereby impose cell cycle arrest. PMID: 20176921
  9. CycE inhibits the function of Prospero and facilitates its cortical localization, which is critical for inducing stem cell behaviour. PMID: 19914234
  10. follicular stem cell function was substantially restored by expressing either excess DE-cadherin or excess E2F1/DP, the transcription factor normally activated by CycE-Cdk2 phosphorylation of retinoblastoma proteins PMID: 19966222
  11. Brm complex mutants suppress the DmcycE(JP) phenotype by increasing S phases w/o affecting DmcycE protein levels. DmcycE physically interacts with Brm & Snr1 in vivo. The Brm complex inhibits S phase by acting downstream of DmcycE protein accumulation. PMID: 12093739
  12. centrosome overduplication still occurs in skpA-; cycE- mutant animals, demonstrating that high cyclin E levels are not necessary for centrosome overduplication PMID: 12730292
  13. we link the CSN to the degradation of Cyclin E, which promotes the G1-S transition in the cell cycle and then is rapidly degraded by the ubiquitin-proteasome pathway PMID: 12737805
  14. asymmetric divisions are due to upregulation of Cyclin E in late ganglion mother cells PMID: 14973280
  15. phosphorylation and degradation of Dup protein at G1/S requires cyclin E/CDK2 PMID: 15342466
  16. string(cdc25) and cyclin E control patterned histone expression at different stages of Drosophila embryonic development. PMID: 15355790
  17. critical role for CycE in regulating cell fate in segment-specific neural lineages. PMID: 15580266
  18. cyclin E functions downstream of the homeotic genes largly independently of its role in proliferation PMID: 15632940
  19. Cell cycle diversity involves differential regulation of Cyclin E activity in the Drosophila bristle cell lineage. PMID: 15829522
  20. The most significant cyclin E alteration is post-translational cleavage of full-length cyclin E into low molecular weight forms that are hyperactive compared to the 50-kDa, full-length protein and correlate with increasing stage of breast cancer. PMID: 16637514
  21. Fondue is a major hemolymph protein required for efficient clotting in Drosophila PMID: 16690050
  22. APC/C-Fzr activity is periodically inhibited by CycE-Cdk2, to prevent relicensing in S-phase cells. PMID: 18559483
  23. Minus contributes to cell cycle regulation in part by selectively controlling turnover of Cyclin E PMID: 19723762

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Subcellular Location
Nucleus.
Protein Families
Cyclin family, Cyclin E subfamily
Tissue Specificity
Isoform II is ubiquitous in early embryos and, prior to mitosis 14, is rapidly degraded in all cells except the pole (germ) cells. Expressed during G1 phase in proliferating peripheral nervous system cells. Constitutive expression in embryonic cycles lack
Database Links

KEGG: dme:Dmel_CG3938

STRING: 7227.FBpp0294012

UniGene: Dm.3509

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