RAP1 Antibody

1. Rap1 (ScRap1) can either activate or repress transcription. This bimodal transcriptional activity has led to the widespread study of the mode of action of ScRap1. This review summarizes current knowledge about ScRap1, including its structure, mechanisms of transcription regulation, and biological functions, and the future directions in the field. Review. PMID: 27100480
2. Pif1, a 5'-3' helicase, not only stimulates the strand displacement activity of Pol delta but it also allows efficient replication through the Rap1 block, by removing bound Rap1 in front of the polymerase. PMID: 27001517
3. that Rap1 contains an AD required for Rap1-dependent gene transcription. The Rap1(AS) variant will likely also be useful for studies of the functions of Rap1 in other biological pathways. PMID: 28196871
4. Rap1 contributes to telomere homeostasis by promoting chromosome breakage. PMID: 26263073
5. found that all arrangements of Rap1 sites tested are represented within the telomeric sequence and our data suggest that at telomeres Rap1 might form a nucleoprotein complex with a heterogeneous distribution of bound states PMID: 25637888
6. Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes PMID: 25805496
7. findings suggest a connection between Rap1p and cell wall homeostasis. PMID: 25481258
8. while Rap1 DNA-binding domain forms a high-affinity 1:1 complex with its DNA recognition site, it can also form lower-affinity complexes with higher stoichiometries on DNA PMID: 25382181
9. Rap1 relocalization is thus a novel mechanism connecting DNA damage responses (DDRs) at telomeres to global changes in chromatin and gene expression while driving the pace of senescence PMID: 23756653
10. Rap1 may cause permanganate hypersensitivity of DNA by forming a pocket between the reactive cytosine and Arg580, driving the permanganate ion towards the C5-C6 bond of the cytosine. PMID: 23519416
11. These data support a model in which Tbf1 and Rap1 collaborate to maintain genomic stability of short telomeres. PMID: 22130795
12. Results reveal Rap1 structural adjustment upon DNA binding that involves a specific orientation of the C-terminal domain with regard to the DNA binding domain. PMID: 22139930
13. Rap1p association with target promoter in the nucleus affects the composition of the exported mRNP, which in turn regulates mRNA decay in the cytoplasm. PMID: 22196725
14. Results show that Rap1 contributes to local regions of chromatin structure by acting at both strong and weak binding sites, at proximal promoter regions and at sites farther upstream, over a very large fraction of the yeast genome. PMID: 21081559
15. Structural comparison indicated that Rap1 BRCT domain adopts a global fold similar to other BRCT domains, implying some common structural aspects of BRCT domain family. PMID: 21187076
16. Data suggest that Rap1 binding to multiple sites in a telomere array does not, by itself, promote formation of a more energetically stabile complex. PMID: 20826803
17. Rap1 is essential to block nonhomologous end joining between telomeres PMID: 16096640
18. The effect on global gene expression of loss of binding of Rap1. PMID: 17158163
19. Rap1 binding is required for end concealment at long tracts and modulates telomerase access at chromosome ends. PMID: 17289918
20. Rap1p represents a heretofore unrecognized regulator of TATA-binding protein PMID: 18195009
21. Structural and functional studies of the RAP1 C-terminus reveal novel separation-of-function mutants. PMID: 18538788

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KEGG: sce:YNL216W

STRING: 4932.YNL216W