Human permeability glycoprotein,P-gp/ABCB1 ELISA Kit

1. Conformational dynamics of P-glycoprotein in lipid nanodiscs and detergent micelles reveal complex motions on a wide time scale. PMID: 29511086
2. Study demonstrated that TWIST protein expression was elevated in liver cancer tissue specimens and was positively correlated with MDR1 expression. Knockdown of TWIST increased the sensitivity of RHepG2 cells to antineoplastic agents through a reduction in MDR1 expression and drug efflux ability. PMID: 30066890
3. the over-expression of SLC7A11, or supplementation with sufficiently cystine, or treatment with N-acetylcysteine significantly decreased P-gp expression and activity. It was suggested that ROS and SLC7A11/cystine were the two relevant factors responsible for the expression and function of P-gp, and that SLC7A11 might be a potential target modulating ADR resistance. PMID: 28630426
4. Data provide a mechanistic explanation for the differential effects of ABCB1 haplotypes on its promoter activity and underscore the importance of evaluating genetic variants in the context of haplotypes rather than individual SNPs when investigating their effects on gene/protein expression and disease risk. PMID: 30277801
5. CYP3A5, ABCB1 and two POR genotypes were assessed by real-time PCR. PMID: 28094348
6. ABCB1 C3435T polymorphism can affect the elimination of some antipsychotic/antidepressant drugs. PMID: 29723928
7. High BCL11A and MDR1 expression was associated with a poor response to chemotherapy. PMID: 29469608
8. The methylation/expression ratios of ABCB1 were unaffected by increasing BMI values. PMID: 27897267
9. Neither the ABCB1 C3435T nor the SLCO1B1 T521C polymorphism affected edoxaban PK. PMID: 27897269
10. Our results show that ABCB1 C3435T polymorphism may modulate serum THC levels in chronic heavy cannabis users. The exact mechanisms and roles that this may play in cannabis dependence genesis and evolution remain to be elucidated. These results should be controlled in a replication study using a larger population. PMID: 28917442
11. MDR1 is not expressed on erythrocyte membrane. PMID: 29098941
12. The genetic polymorphisms of the multi-drug resistance-1 (MDR-1) and human cytochrome P450 3A (CYP3A4 and CYP3A5) genes were analyzed and compared between steroid sensitive, steroid resistant and control groups. PMID: 30143489
13. This meta-analysis suggests that the MDR1 C > T polymorphism was not associated with the risk of MM. To confirm these findings, further comprehensive and well-designed studies are needed. PMID: 29495954
14. High MDR1 expression is associated with chemoresistance in ovarian cancer. PMID: 29956807
15. 13-cis-retinoic acid, retinol and retinyl-acetate inhibited the Pgp and ABCG2 mediated substrate transport as well as the substrate stimulated ATPase activity of these transporters. PMID: 28145501
16. Haplotype analysis of ABCB1 conducted in patients with bullous pemphigoid demonstrated that the 1236T-2677G-3435T haplotype may protect against development of disease. PMID: 29948283
17. High ABCB1 expression is associated with Bendamustine-resistance in Mantle Cell Lymphoma. PMID: 29695404
18. Data show that multidrug resistance gene 1 (MDR1) expression was associated with worsen survival of esophageal squamous cell carcinoma (ESCC) patients with cisplatin-based chemotherapy. PMID: 29107111
19. ABCB1 variation affected myelosuppression, progression-free survival and overall survival in ovarian cancer patients who were treated with paclitaxel and carboplatin PMID: 29504705
20. Our data showed that the expression of the MDR1 gene was significantly higher in malignant tissue than in the normal tissues of patients with STS. In addition, high MDR1 expression was significantly associated with local advances, as well as poor response to treatment. PMID: 29689707
21. These results indicated that MG132 reversed the MDR of hypopharyngeal carcinoma by downregulating Pgp/Pgp, and the underlying mechanism may be associated with the activation the of the JNK signaling pathway PMID: 29901180
22. P-glycoprotein on peripheral blood leukocytes of systemic lupus erythematosus (SLE) patients with lupus arthritis may have a role in clinical response to methotrexate PMID: 28616661
23. This study elaborated a novel UCA1/miR-129/ABCB1 regulatory axis underlying paclitaxel resistance of ovarian cancer cells. PMID: 29777711
24. ABCB1 3435C>T and ATIC 347C>G SNPs were associated with abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis. PMID: 29252093
25. The role of multidrug resistance 1 gene (MDR1 or ABCB1) polymorphism G2677T was studied in relation to paroxetine therapeutic efficacy and its side effects, as well as its association with selected demographic and clinical characteristics of patients with depressive disorder. PMID: 29754150
26. alterations in latrophilin expression occur in AML cells expressing P-gp PMID: 29938681
27. This study demonstrated that the The G2677T T and C3435T T alleles as well as the TT, CTT and TTT haplotypes seemed to be significantly associated with drug-resistance epilepsy in Tunisian epileptic population. PMID: 29198163
28. Pharmacokinetics of aripiprazole is affected by sex and ABCB1 gene phenotype PMID: 29325225
29. There were no significant differences in the bosutinib C0 between genotypes for ABCB1, ABCG2, and CYP3A4 polymorphisms. PMID: 29736778
30. Studies show a connection between UDP-glucose ceramide glucosyltransferase (UGCG) and multidrug resistance protein 1 (MDR1) overexpression and multidrug resistance development [Review]. PMID: 29409484
31. Due to the downregulation of MDR1 and MRP1, the intracellular accumulation of ADM was increased in the transfected cells compared with that in the parental K562/ADM cells..Our research revealed that protein expression of the ERK signaling pathway was inhibited by downregulating TRIB2, indicating that the ERK pathway was involved in cell drug resistance and proliferation. PMID: 29436678
32. Asiatic Acid strongly inhibited P-GP expression by blocking MDR1 gene transcription and increased the intracellular accumulation of the P-GP substrate Rhodamine 123 in MDR1-overexpressing cisplatin (DDP)-resistant lung cancer cells, A549/DDP. PMID: 29768255
33. Ceritinib enhanced the efficacy of substrate chemotherapeutic agent in ABCB1-overexpressing K562/adr leukemia cells both in vitro and in vivo models, but neither in sensitive parental K562 leukemia cells nor in ABCC1-overexpressing HL-60/adr leukemia cells. PMID: 29742496
34. Polymorphism of ABCB1 rs1045642-T variant allele is associated with colorectal cancer. PMID: 29282011
35. There is a certain correlation between the APC gene and ovarian tumors, and the APC gene mediates the apoptosis of tumor cells through the MDR-1/CLCX-1 signaling pathway. PMID: 29921377
36. ABCB1/Pgp expression, activity, and single nucleotide polymorphisms (SNPs) in chronic myeloid leukemia. [review] PMID: 29316665
37. High MDR1 expression is associated with primary myelodysplastic syndrome. PMID: 27605311
38. analysis of the structure of zosuquidar and UIC2-bound human-mouse chimeric ABCB1 PMID: 29440498
39. ABCB1 gene polymorphisms are not associated with response to chemotherapy in breast cancer. PMID: 29113667
40. Patients prescribed with short-term low-dose atorvastatin and carrying ABCB1 (rs1128503) or ABCG2 (rs2231142) SNPs did not show differences in LDL-C response (P>.05). PMID: 28833323
41. Genotypes of UGT1A and ABCB1 were significantly associated with changes in moxifloxacin pharmacokinetic parameters. PMID: 29210323
42. G2677T/A polymorphism of MDR1 may play a significant role in the development of drug-resistant epilepsy in the Polish patients PMID: 28608314
43. No association was found between the ABCB1 SNPs and Crohn's disease in the two populations PMID: 28759738
44. icaritin (ICT) decreased the mRNA and protein levels of multidrug resistance protein 1 (MDR1) in MG-63 doxorubicin-resistant (MG-63/DOX) cells. PMID: 29425587
45. We demonstrate for the first time that the effect of ABCB1 diplotype on tacrolimus disposition is dependent on both CYP3A5 and CYP3A4 genotype. PMID: 27378609
46. these results address key concerns in the field, including that of cross-resistance between taxanes and highlighting a mechanism of cabazitaxel resistance involving ABCB1 PMID: 28698198
47. CYP3A and ABCB1 SNPs were detected in 521 recipients. PMID: 28952408
48. MDR-1 C3435T gene polymorphism was associated with right ventricular dysfunction in patients with chronic obstructive pulmonary disease. PMID: 29791609
49. data suggested that hypomethylation agent decitabine restores drug sensitivity in the P-gp-induced MDR phenotype by depressing of P-gp activity as drug pump partly through MAPK signaling pathway. PMID: 28405849
50. None of the genotypes in ABCB1 1236 C>T, 2677 G>T/A, 3435 C>T, and 4036 A>G correlated with plasma dolutegravir concentration..The speculated peak level of plasma dolutegravir concentration was significantly higher in ABCG2 genetic variant holders, probably, at least in part, because of low expression levels of efflux transporters in the intestines associated with these genetic variants. PMID: 28858994
51. these findings indicated that CH reversed Pglycoprotein-mediated MDR in Ovarian cancer A2780/Taxol cells by inhibiting the PI3K/Akt signaling pathway. PMID: 28791369
52. ABCB1 hypomethylation is associated with lower drug absorption, higher platelet reactivity, and an increased risk of ischemic events in our patients. PMID: 28707077
53. MDR1 gene variants and haplotypes were associated with ulcerative colitis in Serbian patients. PMID: 29543864
54. The novel role of HCAR1 in development of chemoresistance in cervical carcinoma HeLa cells via ABCB1 transporter up-regulation. PMID: 29151072
55. ABCB1 genotype rs1045642 AA is associated with fentanyl administration in a cohort of children admitted to the pediatric intensive care unit, likely because of decreased expression and activity of p-glycoprotein PMID: 28388599
56. These results suggested that ABCB1 rs1045642 and UGT2B7 rs7439366 may affect oxcarbazepine pharmacokinetics and therapeutic efficacy in Han Chinese patients with epilepsy PMID: 28837897
57. results suggest that the ABCB1 3435C > T SNP, the 2677G > T/A SNP and 1236T/2677T/3435C haplotype are significantly associated with AD susceptibility PMID: 27600024
58. MDR1 polymorphisms could affect the prognosis of multiple myeloma. PMID: 28888211
59. Compared with palonosetron, ramosetron may be superior for reducing PONV severity, especially in patients with ABCB1 3435TT or 2677TT genotype PMID: 27564555
60. Study shows that ABCB1 1236C > T-2677G > T-3435C > T polymorphisms affect the sensitivity of human leukemic cells expressing BCR-ABL to tyrosine kinase inhibitors. PMID: 27405085
61. Afatinib Decreases P-Glycoprotein Expression to Promote Adriamycin Toxicity of A549T Cells PMID: 28590019
62. Data indicate functions of multi-drug resistance protein 1 (MDR1) in the hepatocyte and may have an impact on the treatment of copper-related diseases, prominently Wilson disease (WD). PMID: 28805879
63. Data show that multidrug resistance protein 1 (MDR1) single-nucleotide polymorphisms (SNPs) have no effect on the mortality rate of paraquat intoxicated patients. PMID: 27545861
64. No statistically significant correlations for the other nine haplotypes were found. Presented results concerning the relationship of ABCB1 polymorphisms with susceptibility to systemic sclerosis are the first ones that were obtained in a Polish population. They imply that single nucleotide polymorphisms do not affect the risk for SSc, but the 1236 C-2677 G-3435 T haplotype might increase this risk. PMID: 28534442
65. In this study, intestinal drug-drug interactions (DDIs) for substrate drugs of P-glycoprotein were simulated extensively using the extended QGut model and translocation model to explore the determinants of DDI. The results of analyses using both models suggested that permeability and active efflux clearance were the major factors that influenced the fraction absorbed (FA). PMID: 28479352
66. Results suggested that the rs1045642-T allele of the ABCB1 gene may be associated with increased risk for renal function injury in hypertensive patients. PMID: 28792917
67. Established is an MDCK cell line stably overexpressing the human MDR1 transporter. CRISPR-Cas9 gene editing was used to knockout the endogenous cMDR1. Application of this cell line allowed unbiased reclassification of drugs previously defined as both substrates and non-substrates in different studies using commonly used MDCK-MDR1 clones. PMID: 28450237
68. These results suggest that the established models can predict brain exposure from the respective blood concentration-time profiles and rank the magnitude of the Pgp-mediated brain drug-drug interaction potential for both Pgp and Pgp/BCRP substrates in humans. PMID: 28385544
69. ABCB1 polymorphisms are factors influencing the pharmacokinetics of oseltamivir in the body. PMID: 28776352
70. Astragaloside IV reversed the drug resistance of Bel7402/FU cells by downregulating the expression of mdr1 via inhibition of the JNK/cJun/AP1 signaling pathway. PMID: 28713943
71. results of the present study indicate that the G2677T/A polymorphism in the ABCB1 gene may affect the risk of developing bullous pemphigoid PMID: 28207188
72. This study suggests that pre-treatment with miR-495 before chemotherapy could improve the curative effect on MDR1-based multidrug resistance cancer. PMID: 28411377
73. C1236T and C3435T polymorphisms in MDR1 gene and trough levels significantly influence the risk of cytogenetic relapse. MDR1-C3435T genotype might emerge as a potential biomarker to predict the risk of cytogenetic relapse in patients with CML. PMID: 28367681
74. we found that the expression of P-gp in primary MM cells derived from the bone marrow of MM patients was correlated to the hypoxic status of these cells, and that hypoxia induced P-gp expression in MM cells in vitro. We further found that the hypoxia-induced resistance to bortezomib and carfilzomib in MM was reversed by pharmacological inhibition of P-gp by tariquidar. PMID: 28509582
75. The influence of ABCB1 1199G>A polymorphism on the transport of P-gp-mediated substrates showed up as drug-specific. Collectively, the ABCB1 1199G>A polymorphism may impact effective antipsychotics concentration in target cells via mediating the agents transport and distribution. PMID: 29443543
76. the plasma trough concentration/dose (C/D) ratio of apixaban was used as a pharmacokinetic index and all data were stratified according to the presence of ABCB1 (ABCB1 1236C>T, 2677G>T/A, and 3435C>T), ABCG2 (ABCG2 421C>A), and CYP3A5 (CYP3A5*3) .These results indicate that ABCG2 421A/A and CYP3A5*3 genotypes and renal function are considered potential factors affecting trough concentrations of apixaban. PMID: 28678049
77. The CGC/CGC diplotype of ABCB1 polymorphism was associated with variability in cold pain threshold and pain tolerance in healthy males. PMID: 27996183
78. this study presents the structure of human P-glycoprotein in the outward-facing conformation, determined by cryo-electron microscopy at 3.4-angstrom resolution. PMID: 29371429
79. Overexpression of Pygo2 facilitated the expression of P-glycoprotein, which acts as a drug efflux pump, by promoting the transcription of MDR1 at the MDR1 promoter loci, resulting in acceleration of the efflux of paclitaxel in human glioma cells. PMID: 28427190
80. Saikosaponin D could enhance the sensitivity of MCF-7/Adriamycin resistance cells towards ADR by down-regulating MDR1 and P-gp expression. PMID: 28554760
81. Moreover, we found that genotypes rs34743033 3R/2R, rs16430 ins6/del6, rs1045642 CC or CT, and rs2032582 GG were beneficial predictors of clinical treatment outcome in AGC patients, suggesting some clinical implications in chemotherapy of a Chinese population. PMID: 28074308
82. Patients with both CYP3A5*3/*3 and MDR1 G2677A who underwent renal transplantation had higher blood TAC concentrations than those without those genotypes. Japanese patients should be carefully monitored for consideration of lower TAC doses, because 24% of Japanese patients have double mutations. PMID: 28736028
83. In this meta-analysis, we summarized the existing data on the associations of ABCB1 C3435T polymorphism with clopidogrel response, including biological and clinical outcomes in patients receiving clopidogrel antiplatelet treatment. The results show that the C3435T variant may increase the risk of bleeding in the Asian population, but no reliable findings were obtained about other outcomes. PMID: 28378058
84. Among two SNPs in CYP3A4 and CYP3A5 and 12 SNPs in ABCB1 gene, an association with ovarian cancer risk was observed for ABCB1 rs2157926 SNP only. PMID: 29491071
85. the allelic association of MDR1 C3435T and the association of the MDR1 3435 CC genotype with risk of drug-resistance were significant among European population PMID: 28284049
86. Promoter methylation was found to be an important mechanism in gene regulation of ABCB1 in parental cancer cell lines and their drug-resistant sublines. PMID: 27689338
87. Its polymorphism significantly affects the therapeutic efficacy of tarcolimus at 12 weeks under the tight dose-adjusting treatment for ulcerative colitis. PMID: 28135009
88. Contribution of tumor endothelial cells to drug resistance: anti-angiogenic tyrosine kinase inhibitors act as p-glycoprotein antagonists. PMID: 28389777
89. Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin by inhibiting energy metabolism which may suppress P-gp function. PMID: 28052008
90. Results imply that LHBs, in association with HIF-1alpha, induces MDR1 overexpression, which may contribute to the pathogenic changes in chronic hepatitis B infection. PMID: 27999186
91. endothelin-A receptor-activated ABCB1 expression has a role in nintedanib resistance in FGFR1-driven small cell lung cancer PMID: 27367030
92. Review/Meta-analysis: CRISPR-Cas9 system is a useful tool for the modification of ABCB1 gene and reversing multi-drug resistance in osteosarcoma cells. PMID: 27835872
93. ABCB1 expression represents the primary (sometimes exclusive) resistance mechanism in neuroblastoma cells with acquired resistance to SNS-032. PMID: 27517323
94. Histone deacetylase inhibitors induce P-gp expression in colorectal cancer in two distinct ways: transcriptional activation and mRNA stabilization PMID: 27409663
95. Ectopic expression of ABCB1 promoted the miR-595-overexpressing HO8910PM and SKOV-3 cell proliferation, colony formation and invasion. PMID: 27893429
96. We compared the carrier frequency of Cytochrome P450 Enzymes and Transport Proteins markers among the Russian population living in Moscow with Dagestan ethnic groups. Statistically significant differences for the following gene polymorphisms: CYP2C19*17, CYP2C9*3, ABCB1 (C3435T), SLCO1B1*5 were found between the Russian population and the three ethnic groups of the Dagestan republic. PMID: 29023140
97. MDR1 C1236T polymorphism may have a minor effect on cyclosporine pharmacokinetics in transplantation patients PMID: 29381954
98. Hypermethylation of CpG islands in MDR1 gene promoter region is obvious in DCTPP1-knockdown BGC-823 gastric cancer (GC) cells. PMID: 27612427
99. Out of all the patients with diminished CYP3A5 enzymatic activity, 68.7% had diminished activity of ABCB1 transporter. Further studies are necessary in order to show the influence of these genetic polymorphisms on tacrolimus blood concentrations. PMID: 29314799
100. meta-analysis evidence that C3435T polymorphism is associated with a decreased risk of colorectal cancer in Asian population PMID: 29390571

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HGNC: 40

OMIM: 171050

KEGG: hsa:5243

STRING: 9606.ENSP00000265724

UniGene: Hs.489033