Recombinant Human Interleukin-1 receptor antagonist protein(IL1RN) (Active)

In Stock
Code CSB-AP001681HU
Product Type Interleukin
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P18510
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias IL-1RN, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 40 ng/ml, corresponding to a specific activity of >2.5x104 IU/mg in the presence of 50 pg/ml rHuIL-1α.
Purity >96% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence RPSGRKSSKM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNV NLEEKIDVVP IEPHALFLGI HGGKMCLSCV KSGDETRLQL EAVNITDLSE NRKQDKRFAF IRSDSGPTTS FESAACPGWF LCTAMEADQP VSLTNMPDEG VMVTKFYFQE DE
Research Area Immunology
Source E.coli
Gene Names IL1RN
Expression Region 26-177aa
Tag Info Tag-Free
Mol. Weight 17.1 kDa
Protein Description Full Length of Mature Protein
PubMed ID 2139180; 2137201; 1828896; 1385987; 8992991; 1827201; 7629520; 14702039; 15815621; 15489334; 2137200; 2143761; 9514884; 7989776; 7775431; 11991722; 8786086; 16335952; 19494218; 1534997; 8045306; 8175703; 7867645; 9062194; 18987736
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Function Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
Involvement in disease Microvascular complications of diabetes 4 (MVCD4); Interleukin 1 receptor antagonist deficiency (DIRA)
Subcellular Location Isoform 1: Secreted, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, SUBCELLULAR LOCATION: Isoform 4: Cytoplasm
Tissue Specificity The intracellular form of IL1RN is predominantly expressed in epithelial cells.
Database Links

HGNC: 6000

OMIM: 147679

KEGG: hsa:3557

STRING: 9606.ENSP00000259206

UniGene: Hs.81134

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