Recombinant Human Interleukin-23 receptor(IL23R),partial (Active)

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Code CSB-AP004371HU
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity The ED50 as determined by its ability to binding recombinant human IL-23A&IL12B used funtional ELISA is less than 5 ug/ml.
Target Names IL23R
Uniprot No. Q5VWK5
Research Area Immunology
Alternative Names IL 23R; IL-23 receptor; IL-23R; IL23 Receptor; Il23r; IL23R_HUMAN; Interleukin 23 receptor ; Interleukin-23 receptor
Species Homo sapiens (Human)
Source Mammalian cell
Expression Region 24-353aa
Complete Sequence GITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGD
Mol. Weight 65 kDa
Protein Length Partial
Tag Info C-terminal FC-tagged
Form Lyophilized powder
Buffer Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Gene References into Functions
  1. IL23R (rs10889677) polymorphism did not show any association with rheumatic heart disease in South Indian population PMID: 29985710
  2. Study confirms an association between IL12B and IL23R genetic polymorphism and psoriasis vulgaris (with a protective effect of minor alleles). PMID: 29454820
  3. The IL23R gene rs10889677 A allele confers increased risk of ankylosing spondylitis (AS) in Europeans, but its role in Asian populations needs further exploration. PMID: 29198991
  4. these findings suggest that the variants +2199 A/C IL-23R and -197 G/A IL-17A could contribute to rheumatoid arthritis development in the studied population PMID: 28547498
  5. Data show that interleukin-23 receptor (IL-23R) single nucleotide polymorphism (SNP) rs11465817 contributes to the risk of recurrent oral ulceration (ROU) in Chinese. PMID: 29169427
  6. Findings indicate that IL17A -197 G/A and IL23R H3Q are not associated with susceptibility to MM. However, IL-17 and IL-23R polymorphisms may affect severity, bone lesions, and extra-medullary disease in patients with MM. PMID: 28786198
  7. This study provides evidence for three alcohol-induced ONFH susceptibility genes (NOS3, ABCB1 and IL23R) in Chinese males and polymorphisms of them may be associated with alcohol-induced ONFH risk. PMID: 28422712
  8. genetic association studies in population in southwest China: Data suggest that SNPs in STAT4 (rs7574865), IL23R (rs11209032), and STAT3 (rs744166) are associated with occurrence, severity, and immunosuppressive therapy outcomes of aplastic anemia in the population studied. (STAT = signal transducer and activator of transcription) [article includes Meta-Analysis] PMID: 29330562
  9. Study provides a comprehensive examination of the available evidence for the association between polymorphisms in the IL-23R gene and ulcerative colitis (UC). The meta-analysis suggests that IL-23R gene polymorphisms are associated with UC susceptibility, especially in Caucasians. PMID: 27902482
  10. Data indicate that the interleukin-23 receptor (IL-23R) SNPs rs11209026, p.Arg381Gln; rs41313262 p.Val362Ile were not associated with susceptibility to inflammatory bowel disease (IBD) in Chinese Han population. PMID: 27765927
  11. Interleukin-23 receptor cytokine-binding homology region balances the ratio of Th17/Th9/Treg cells in collagen-induced arthritis. PMID: 27177334
  12. this meta-analysis suggests that each allele of IL-23R, including rs7519847, rs17375018 and rs11209032 was negatively associated with uveitis; however, homozygote models, including the rs17375018 GG genotype and rs11209032 AA genotype, were significantly associated with uveitis PMID: 28558665
  13. an evaluation of what is currently known about the protective role of R381Q variant in IL-23R gene in immune-based diseases (Review). PMID: 27043356
  14. Th17 cells expressed consistent high levels of the IL-12Rbeta1 subunit, which appeared a better predictor of responsiveness to IL-23 than the expression of the IL-23R subunit. PMID: 27645493
  15. We conclude that variants in IL-23A and IL-23R genes were associated with the risk of multiple sclerosis or other inflammatory demyelinating diseases. PMID: 27893410
  16. IL-23 R (rs7517847) and LEP (rs7799039) polymorphisms were associated with an increased risk but not affecting the clinical presentation of HCC among Egyptian patients PMID: 28452232
  17. In a Turkish population, IL23R polymorphism is a risk factor for UC and is protective against CD. PMID: 27852544
  18. The current study emphasizes the lack of association of IL23R and IL17 polymorphisms with rheumatoid arthritis susceptibility in the Algerian population. However, the data showed the relationship between IL23R and IL17A polymorphisms and the production of the different RF isotypes in rheumatoid arthritis patients PMID: 27606475
  19. Haplotype of non-synonymous IL-23R variants increase susceptibility to severe malarial anemia in children of a holoendemic P. falciparum transmission area. PMID: 28427357
  20. there is a positive association between the GWAS reported rs3762318 and leprosy, and SLC35D1 and IL23R might be the causal genes PMID: 27712858
  21. this study identified susceptibility single nucleotide polymorphisms in IL23R with Behcet's disease in Han Chinese PMID: 27464962
  22. HLA-B51 is a primary association marker in predisposition to Behcet disease, with IL-23R and IL12A being the additional strongest loci. PMID: 27548383
  23. Study identified a possible silencer downstream of IL23R that includes the ankylosing spondylitis (AS)-associated SNP rs924080, which appears to modulate the functional effects of this regulatory element; confirmed the primary association of AS with rs11209032 in this region, but suggest that there could be a possible additional effect from rs924080 in a putative silencer on the same haplotype. PMID: 28381868
  24. Study demonstrated susceptible or protective character of the investigated IL23R SNPs on the phenotype of ulcerative colitis, confirming the genetic association. PMID: 28210080
  25. In ankylosing spondylitis, conditional analysis identified rs11209032 as the probable causal single-nucleotide polymorphism within a 1.14 kb putative enhancer between IL23R and IL12RB2. The rs11209032 single-nucleotide polymorphism downstream of IL23R forms part of an enhancer, allelic variation of which may influence Th1-cell numbers. PMID: 26916345
  26. Results did not show any strong association between IL-23R polymorphisms and juvenile idiopathic arthritis or serum IL-17A levels in Iranian patients. PMID: 26016922
  27. The results of this case-control study suggest that IL-12A, IL-12B, IL12RB1, IL12RB2 and IL23R make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations PMID: 26987707
  28. this study shows a lack of association of the IL-23 single nucleotide polymorphisms with the risk of acute lymphoblastic leukemia in Iran PMID: 28341819
  29. The interleukin-23 receptor gene polymorphism may not contribute to the susceptibility of development of primary immune thrombocytopenia in Egyptian children. PMID: 26859125
  30. this study shows that there is no significant difference in mucosal IL-23R expression in Ulcerative Colitis patients with moderate-to-severe disease activity compared to those in remission PMID: 27178149
  31. In this study, we were unable to establish a correlation between the IL-23R SNPs investigated and HLA-B27-associated acute anterior uveitis as well as idiopathic intermediate uveitis. PMID: 27009486
  32. These results suggest that IL23R may contribute to the development of intracerebral hemorrhage. PMID: 26846416
  33. The association of IL-23R and Ankylosing Spondylitis (AS) that is seen in Caucasian patients with AS is not present in Chinese patients with AS. PMID: 27650612
  34. Differential splicing generates antagonistic soluble IL-23R (sIL-23R) variants, which might limit IL-23-mediated immune responses. Here, ectodomain shedding of IL-23R was identified as an alternative pathway for the generation of sIL-23R. PMID: 26961870
  35. genetic polymorphism is associated with psoriasis in the South Indian Tamils PMID: 26472011
  36. A significant association was found between all Crohn's disease and the rs7517847 polymorphism, especially in Caucasians. PMID: 26678098
  37. The IL23R polymorphisms rs10889677, rs7517847, and the IL12B polymorphism rs3212227 are not associated with multiple sclerosis risk. PMID: 26000455
  38. results suggest a convergent cause of IL23Ralpha variant protection against chronic inflammatory disease. PMID: 26887945
  39. meta-analysis supports that two polymorphisms (rs11209026 and rs7517847) in the IL-23 gene may be considered to be protective factors against developing UC among Caucasian populations. PMID: 25497273
  40. The results of the current study disclosers1343151 variant of IL23R as a susceptibility gene in CD. PMID: 25561320
  41. Lower LCN2 levels in Crohn's Disease patients carrying IBD risk-increasing IL23R variants may result from a restricted upregulation of LCN2 due to an impaired Th17 immune response PMID: 26263469
  42. IL23 receptor single nucleotide polymorphisms and gene copy number variation are associated with susceptibility to pulmonary tuberculosis in Chinese Uygurs. PMID: 26626589
  43. These results indicated an association between the rs11209026 G>A polymorphism of the IL-23 receptor gene and the risk of atherosclerosis. PMID: 26261042
  44. Low-Frequency IL23R Coding Variant is Associated with Crohn's Disease Susceptibility. PMID: 26375822
  45. R381Q polymorphism in IL-23 receptor may be a predisposing allele for asthma. PMID: 26547706
  46. GG genotype of the rs17375018 variant in the IL-23R gene enhances pro-inflammatory cytokine responses in Behcet's Disease. PMID: 26222305
  47. it is concluded that the frequency of single nucleotide polymorphism in the IL-23 receptor (R381Q) in patients with recurrent spontaneous abortion (RSA) is less than that found in normal control women. PMID: 26269135
  48. review and meta-analysis of association of polymorphisms rs6682925, rs10889677 and rs1884444 with cancer risk PMID: 26717375
  49. Copy number variation of exon 11 in IL-23R is associated with pulmonary tuberculosis in the Chinese Uygur population. PMID: 26829744
  50. IL-17A and IL-23R gene polymorphism were not associated with acute myeloid leukemia susceptibility. PMID: 26191290
  51. the distribution of interleukin (IL)-12 (IL12; 1188A/C), IL17 (A7488G) and IL-23 receptor (IL23R; +2199A/C) gene polymorphisms in patients with alopecia areata, was investigated. PMID: 26017027
  52. strong additive interaction exists between IL23R SNPs and smoking behavior resulting in a dramatic increase in disease risk depending upon specific genetic background PMID: 24989722
  53. There were no relationships between IL17A, IL23R and the survival of colorectal cancer patients neither with nor without the treatment. PMID: 26083022
  54. The study demonstrated that polymorphism of IL-23R gene is highly associated with HT in Chinese Han population of Shandong, suggesting that IL-23R gene polymorphism may play a critical role in susceptibility to Hashimoto's Thyroiditis . PMID: 26228217
  55. IL-23R genes confer susceptibility to CD in the Caucasians. PMID: 26090488
  56. IL23 receptor AA genotype variant of rs11209026 would contribute to rheumatoid arthritis etiology; consequently, it might be a genetic marker for rheumatoid arthritis. PMID: 25858864
  57. Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto's thyroiditis PMID: 25863684
  58. IL-23R may be associated with gout in a Chinese Han male population, although our findings should be confirmed using larger sample sizes and other independent populations. PMID: 25661540
  59. The genetics of psoriatic arthritis (PsA) reveals susceptibility loci and a distinct PsA-specific variant at the IL23R locus. PMID: 25651891
  60. Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma. PMID: 26242299
  61. For IL23R, rs11209026, rs1004819, and rs1495965 single nucleotide polymorphisms were found not to be associated with the development of Crohn's disease. PMID: 25048429
  62. STAT3 signaling downstream of IL-23R and IL-21R has a role in controlling human mucosal-associated invariant T cells and NKT cell numbers PMID: 25941256
  63. the frequency of the T allele at position rs1343151 was significantly higher in the patient group, compared to the controls (P=0.018: a new susceptibility locus associated with ulcerative colitis PMID: 24485526
  64. The result indicates that IL23R may play an important role in the susceptibility of bladder cancer in Chinese population. PMID: 24861772
  65. No genetic association was found with IL23R gene snps and multiple sclerosis susceptibility in a Chinese southern population. PMID: 24547735
  66. We found that patients with Behcet disease had a lower frequency of the rs17375018 GA and AA genotypes, and a higher frequency of the rs17375018 G allele. PMID: 25156021
  67. Non-synonymous variant rs1884444 T > G of IL-23R is associated with a decreased risk to schistosomiasis-associated immune reconstitution inflammatory syndrome in a Kenyan population. PMID: 24912586
  68. genetic association studies in Croatian population: Data suggest that SNPs in IL23R (rs11209026, Arg381Gln; rs7530511) are not associated with susceptibility to or severity of Hashimoto's thyroiditis in the population studied. [PILOT STUDY] PMID: 24460100
  69. In this Algerian cohort, IL23R was associated with CD's outcomes and linked to a particular clinical phenotype PMID: 24679666
  70. Data indicate that IL-23 p19, IL-23 p40 (IL-12 p40) and IL-23 receptor (IL-23R) were cytoplasmic/membranous over-expressed in colorectal cancer and normal tissues, but were reduced in lymph node metastases. PMID: 25015728
  71. The study suggests that wild type IL-23R GG serves as a risk factor for hepatocellular carcinoma and supports for the protective role of the rare variant rs11209026 (Arg381Gln) against HCV-related hepatocellular carcinoma in Egyptian patients. PMID: 25666505
  72. Data indicate that interleukin 23 receptor (IL-23R) G allele increases risk to develop psoriatic arthritis. PMID: 24910145
  73. genetic variation at IL12B, IL23R and IL23A has an influence not only on the risk for psoriasis but also on disease severity and type 2 diabetes mellitus PMID: 24957500
  74. The human IL-23 receptor rs11209026 A allele promotes the expression of a soluble IL-23R-encoding mRNA species. PMID: 25552541
  75. IL-23R gene polymorphisms alone were not shown to be associated with AS in Iranian population PMID: 24998354
  76. The IL-23/IL-23R/IL-12Rbeta1 complex formation does not follow the classical "site I-II-III" architectural paradigm. PMID: 25371211
  77. results suggest the rs924080 risk A allele does not affect baseline expression of IL-12RB2, IL-23R, IFN-gamma and TNF-alpha but enhances IL-23R and TNF-alpha expression capacity in response to LPS stimulation; the A allele appears to enhance baseline IL-6 production PMID: 24434271
  78. a differential regulation pattern for genes solely expressed in Th17 cells (IL17A and CCL20) compared to genes expressed in both Th17 and Th1 cells (IL23R and IL12RB2), where high levels of promoter methylation are correlated to near zero PMID: 22715389
  79. Subjects carrying rs6682925TC and CC genotypes had significantly increased mRNA level of IL-23R in peripheral blood mononucleated cells than those with TT genotype. PMID: 25192515
  80. Characterization of potent IL-23R small-peptide modulator, 2305 (teeeqqly), that decreases inflammatory response. PMID: 25354400
  81. the IL-23R rs10889677 genetic variant might play an important part during malignant transformation of multiple solid tumors (Meta-Analysis) PMID: 24278297
  82. The findings indicated that rs10889677A>C polymorphism in IL-23R may play a protective role in mediating the risk of ESCC. PMID: 24586528
  83. No evidence of association between common autoimmunity STAT4 and IL23R risk polymorphisms and non-anterior uveitis. PMID: 24312163
  84. The data presented here show profound differences in the IL23R genetic profiles in the Roma population. PMID: 24332578
  85. Phosphorylated STAT3 and PD-1 regulate IL-17 production and IL-23 receptor expression in Mycobacterium tuberculosis infection. PMID: 24643836
  86. genetic polymorphism is associated with graft outcome after kidney tarnsplantation PMID: 24211680
  87. This study demonistrated that the IL23R genetic polymorphisms are associated with Alzheimer disease in a Northern Han Chinese. population. PMID: 24703098
  88. Data indicate that in addition to HLA-B*57 as a risk factor in Behcet's disease (BD), three single nucleotide polymorphisms (SNPs)located in IL23R and one of the SNPs in IL10 were found to be significantly associated with susceptibility to BD. PMID: 24286189
  89. Il23R SNPs are associated with phenotype and response to drug therapy in ulcerative colitis. PMID: 24168842
  90. no association between genetic polymorphism and ulcerative colitis in Iranian population PMID: 22735800
  91. genetic polymorphisms are associated with psoriasis risk in Europeans PMID: 23844553
  92. IL-23R AC carriers and C allele have predictive values for acute rejection. AC genotype and C allele is a risk factor for development of acute rejection. AA and AC genotype is a sex dependent genetic risk factor for development of acute rejection. PMID: 24313807
  93. Results suggest a relationship between certain TNF-alpha and IL23R polymorphisms and the short-term response to anti-TNF-alpha drugs. PMID: 23662788
  94. The IL23R gene rs17375018 GG genotype and the G allele were increased in AS patients who were HLA-B27 positive. PMID: 23840727
  95. Associations presented in this study give potentially important insight into the roles of specific Interleukin-23 receptor polymorphisms in Crohn's disease pathogenesis in the Croatian population PMID: 24611330
  96. These observations indicate that the genetic variants in the IL23R gene may contribute to HCC development. PMID: 23807368
  97. The IL23R nonsynonymous polymorphism rs11209026 is associated with radiographic sacroiliitis in spondyloarthritis. PMID: 23818276
  98. The single nucleotide polymorphisms (rs10889677 and rs1884444) in the IL-23R gene do not play a role in systemic lupus erythematosus susceptibility in a Chinese population. PMID: 23754344
  99. findings reveal that the IL-23R rs6682925 and rs10889677 genetic variants play a more important part in pathogenesis of multiple cancers PMID: 24076440
  100. A strong association between rs7517847 in a SNP of IL-23R, and allergic rhinitis was identified. PMID: 23696856

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Involvement in disease Inflammatory bowel disease 17 (IBD17)
Subcellular Location Cell membrane, Single-pass type I membrane protein
Protein Families Type I cytokine receptor family, Type 2 subfamily
Tissue Specificity Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Database Links

HGNC: 19100

OMIM: 607562

KEGG: hsa:149233

STRING: 9606.ENSP00000321345

UniGene: Hs.677426

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