Recombinant Human Interleukin-23 receptor(IL23R),partial (Active)

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Code CSB-AP004371HU
Product Type Interleukin
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Uniprot No. Q5VWK5
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Storage Buffer Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
Alias Interleukin-23 receptor; IL23R; IL-23 receptor; IL-23R
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined by its ability to binding recombinant human IL-23A&IL12B used funtional ELISA is less than 5 ug/ml.
Purity Greater than 90% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence GITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGD
Research Area Immunology
Source Mammalian cell
Gene Names IL23R
Expression Region 24-353aa
Tag Info C-terminal FC-tagged
Mol. Weight 65 kDa
Protein Description Partial
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Function Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Involvement in disease Inflammatory bowel disease 17 (IBD17)
Subcellular Location Cell membrane, Single-pass type I membrane protein
Protein Families Type I cytokine receptor family, Type 2 subfamily
Tissue Specificity Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Database Links

HGNC: 19100

OMIM: 607562

KEGG: hsa:149233

STRING: 9606.ENSP00000321345

UniGene: Hs.677426

Pathway Jak-STAT signaling pathway
Th17 cell differentiation

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