Name: A2ML1 Antibody, Biotin conjugated
Brand: CUSABIO
SKU: CSB-PA001005LD01HU

Product Details

Full Product Name	Rabbit anti-Homo sapiens (Human) A2ML1 Polyclonal antibody
Uniprot No.	A8K2U0
Target Names	A2ML1
Alternative Names	A2ML1 antibody; CPAMD9Alpha-2-macroglobulin-like protein 1 antibody; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9 antibody
Raised in	Rabbit
Species Reactivity	Human
Immunogen	Recombinant Human Alpha-2-macroglobulin-like protein 1 protein (625-751AA)
Immunogen Species	Homo sapiens (Human)
Conjugate	Biotin
Clonality	Polyclonal
Isotype	IgG
Purification Method	>95%, Protein G purified
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Tested Applications	ELISA
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
Gene References into Functions	The functional assessment supported the pathogenicity of the RAF1 and RIT1 variants of unknown significance (VUSs), while the significance of two VUSs in A2ML1 remained unclear. PMID: 29402968 The indigenous Filipino population has a ~50% prevalence of otitis media. A2ML1 genotype is the primary risk factor for otitis media and main determinant of disease progression, although age, the middle ear microbiome, and social clusters might modulate the effect of the A2ML1 genotype. PMID: 27484237 A2ML1-related otitis media susceptibility may be mediated by changes in the middle ear microbiome. PMID: 27799062 Studies support a role for alpha-2-macroglobulin-like 1 protein (A2ML1) in the pathophysiology of otitis media. PMID: 26121085 our results provide evidence that mutations in A2ML1 are a cause of Noonan-like syndrome, with a variable phenotype ranging from severe to very mild. PMID: 24939586 a new class of target antigens in a paraneoplastic autoimmune multiorgan syndrome PMID: 20805888 alpha2ML1 is the first alpha2macroglobulin family member detected in the epidermis, where it may play an important role during desquamation by inhibiting extracellular proteases. PMID: 16298998 alpha2ML1 binding to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis PMID: 18648652 Show More Hide All
Subcellular Location	Secreted
Protein Families	Protease inhibitor I39 (alpha-2-macroglobulin) family
Tissue Specificity	In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.
Database Links	HGNC: 23336 OMIM: 610627 KEGG: hsa:144568 STRING: 9606.ENSP00000299698 UniGene: Hs.620532

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Code	CSB-PA001005LD01HU
Size	US$299
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A2ML1 Antibody, Biotin conjugated

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Target Data

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