ABCC6 Antibody

Datasheet
Code CSB-PA001065LA01HU
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Size US$299
Uniprot No. O95255
Image
  • Immunofluorescence staining of A549 cells with CSB-PA001065LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunogen Recombinant Human Multidrug resistance-associated protein 6 protein (730-931AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IF; Recommended dilution: IF:1:50-1:200
Relevance Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Multidrug resistance-associated protein 6 (ATP-binding cassette sub-family C member 6) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E), ABCC6, ARA MRP6
Immunogen Species Human
Protocols ELISA Protocol
Immunofluorescence (IF) Protocol
Research Area Signal Transduction
Target Names ABCC6
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Isoform 1
Involvement in disease Pseudoxanthoma elasticum (PXE); Arterial calcification of infancy, generalized, 2 (GACI2)
Subcellular Location Isoform 1: Basolateral cell membrane, Multi-pass membrane protein, SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum membrane, Single-pass membrane protein
Protein Families ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Tissue Specificity Expressed in kidney and liver. Very low expression in other tissues.
Database Links

HGNC: 57

OMIM: 264800

KEGG: hsa:368

STRING: 9606.ENSP00000205557

UniGene: Hs.442182

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