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| Code | CSB-PA001411 |
| Size | US$167 |
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| Have Questions? | Leave a Message or Start an on-line Chat |
| Uniprot No. | Q9NPB9 | ||||||||
| Target Names | ACKR4 | ||||||||
| Alternative Names |
ACKR4; CCBP2; CCR11; CCRL1; VSHK1; Atypical chemokine receptor 4; C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; CCX CKR
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| Raised in | Rabbit | ||||||||
| Species Reactivity | Human,Mouse | ||||||||
| Immunogen | Synthesized peptide derived from the C-terminal region of Human CCRL1. | ||||||||
| Immunogen Species | Homo sapiens (Human) | ||||||||
| Conjugate | Non-conjugated | ||||||||
| Isotype | IgG | ||||||||
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | ||||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||||
| Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. | ||||||||
| Form | Liquid | ||||||||
| Tested Applications | WB, IF, ELISA | ||||||||
| Recommended Dilution |
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| Protocols | Western Blotting(WB) Protocol Immunofluorescence (IF) Protocol ELISA Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
Applications : immunoblot
Sample type: cells
Review: MBrC suffered V. harveyi infection for different times and ACKR4a protein was detected by immunoblot.
By Anonymous
| Function |
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
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| Gene References into Functions |
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| Subcellular Location | Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. |
| Protein Families | G-protein coupled receptor 1 family, Atypical chemokine receptor subfamily |
| Tissue Specificity | Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine. |
| Database Links |
HGNC: 1611 OMIM: 606065 KEGG: hsa:51554 STRING: 9606.ENSP00000249887 UniGene: Hs.310512 |
