ADCY10 Antibody, FITC conjugated

1. results thus provide 1) novel insights into the communication between allosteric regulatory and active sites, 2) a novel mechanism for sAC inhibition, and 3) pharmacological compounds targeting this allosteric site and utilizing this mode of inhibition. PMID: 26961873
2. The data support an important role for prostaglandin activation of sAC and PKA in H2O2-induced barrier disruption. PMID: 26857816
3. Evaluation of soluble adenylyl cyclase expression using R21 antibody is a useful diagnostic adjunct in the evaluation of margins of LM during slow Mohs surgery. PMID: 24698940
4. shows that in fibroblast cultures inhibition by KH7 of production in the mitochondrial matrix by soluble adenylyl cyclase PMID: 25409931
5. Crystal structures of human ADCY10 catalytic domains in complex with nucleotides. PMID: 25040695
6. Soluble adenylyl cyclase plays a role in the regulation of basal cCMP and cUMP. PMID: 24792377
7. sAC is a regulator of gene expression involved in aldosterone signaling and an important regulator of endothelial stiffness. PMID: 24420537
8. sAC is necessary for normal glucose-stimulated insulin secretion in vitro and in vivo. PMID: 24100033
9. a haem-binding domain within the C-terminus of the human soluble adenylate cyclase PMID: 22775536
10. Significant overexpression of soluble type 10 adenylyl cyclase (sAC), an alternative source of cAMP, was found in human prostate carcinoma. PMID: 23255611
11. Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body. PMID: 21994938
12. sAC may play a role in the pathogenesis of certain hyperproliferative skin disorders via modulation of gene expression PMID: 20130594
13. Soluble adenylyl cyclase is localized to motile airway cilia and it contributes to the regulation of human airway ciliary beat frequency. PMID: 17591988
14. These results show that bicarbonate-controlled sAC stimulation must be taken into account in cell physiology and that basal CFTR expression depends on an ionic parameter. PMID: 18209474
15. a modest association between an ADCY10 polymorphism and the spinal areal BMD in premenopausal white women. PMID: 19093065

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HGNC: 21285

OMIM: 143870

KEGG: hsa:55811

STRING: 9606.ENSP00000356825

UniGene: Hs.320892