Acss2 Antibody

Code CSB-PA882544LA01MO
Size US$166
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  • Western Blot
    Positive WB detected in: Rat heart tissue, Mouse heart tissue
    All lanes: Acss2 antibody at 4μg/ml
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 79 kDa
    Observed band size: 79, 50 kDa

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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Acss2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Acss2 antibody; Acas2 antibody; Acecs1Acetyl-coenzyme A synthetase antibody; cytoplasmic antibody; EC antibody; Acetate--CoA ligase antibody; Acetyl-CoA synthetase antibody; ACS antibody; AceCS antibody; Acetyl-CoA synthetase 1 antibody; AceCS1 antibody; Acyl-CoA synthetase short-chain family member 2 antibody; Acyl-activating enzyme antibody; Propionate--CoA ligase antibody; EC antibody
Raised in
Species Reactivity
Mouse, Rat
Recombinant Mouse Acetyl-coenzyme A synthetase, cytoplasmic protein (1-701AA)
Immunogen Species
Mus musculus (Mouse)

The Acss2 Antibody (Product code: CSB-PA882544LA01MO) is Non-conjugated. For Acss2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA882544LB01MO Acss2 Antibody, HRP conjugated ELISA
FITC CSB-PA882544LC01MO Acss2 Antibody, FITC conjugated
Biotin CSB-PA882544LD01MO Acss2 Antibody, Biotin conjugated ELISA
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity.
Gene References into Functions
  1. ACSS2 promotes the systemic storage or metabolism of fat according to the fed or fasted state through the selective regulation of genes involved in lipid metabolism. PMID: 30228117
  2. results reveal a connection between cellular metabolism, gene regulation, and neural plasticity and establish a link between acetyl-CoA generation 'on-site' at chromatin for histone acetylation and the transcription of key neuronal genes. PMID: 28562591
  3. Study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. PMID: 25584894
  4. Study reports evidence that the nucleocytosolic ACSS2 enzyme is of critical importance for mammalian cells to utilize acetate as a source of acetyl-CoA, and that mice lacking this enzyme exhibit a substantial reduction in tumor burden in two genetic models of liver cancer. PMID: 25525877
  5. Study shows that ACSS2 is upregulated in the human orthotopic tumor and primary human tumors, as well as a murine glioma model; the tumors do not oxidize [U-(13)C]glutamine. In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase enzyme 2, ACSS2. PMID: 25525878
  6. Acss2 generates a specific pool of acetyl CoA during hypoxia that modulates interactions of the acetylase/coactivator Cbp (also known as Crebbp) with the stress-responsive transcription factor, Hif-2. Because erythropoietin is a Hif-2 target gene, red blood cell production in mice is also regulated by Acss2. Recovery from anemia is accelerated by administering acetate, although this requires the presence of Acss2. PMID: 25108527
  7. Acetyl CoA synthetase-1 (AceCS1) is mainly expressed in oligodendrocytes in the rat brain. It is located both in cytosol and nucleus of mammalian cells. PMID: 20533355
  8. Expression of cytosolic acetyl-CoA synthetase gene in mice is developmentally regulated PMID: 12049778
  9. ACSS2 might play a buffering role in tumor acetyl-CoA/acetate metabolism PMID: 19445015

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Subcellular Location
Cytoplasm, cytosol.
Protein Families
ATP-dependent AMP-binding enzyme family
Database Links
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