B4GAT1 Antibody, Biotin conjugated

Code CSB-PA002499ED01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) B4GAT1 Polyclonal antibody
Uniprot No. O43505
Target Names B4GAT1
Alternative Names 3-N-acetylglucosaminyltransferase 1 antibody; 3-N-acetylglucosaminyltransferase antibody; B3GN-T1 antibody; B3GN1_HUMAN antibody; B3GNT1 antibody; B3GNT6 antibody; beta-1,3-N-acetylglucosaminyltransferase bGnT-6 antibody; BETA3GNTI antibody; I-beta-1 antibody; i-beta-1,3-N-acetylglucosaminyltransferase antibody; iGAT antibody; iGnT antibody; N-acetyllactosaminide beta-1 antibody; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase antibody; OTTHUMP00000235058 antibody; Poly-N-acetyllactosamine extension enzyme antibody; UDP-GlcNAc:betaGal beta-1 antibody; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 antibody; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Beta-1,4-glucuronyltransferase 1 protein (161-415AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan
Gene References into Functions
  1. B4GAT1 is involved in the initiation of the LARGE-dependent repeating disaccharide that is necessary for extracellular matrix protein binding to O-mannosylated alpha-dystroglycan. PMID: 25279697
  2. report describes the first truncating mutation in B3GNT1 and confirms that this gene, which plays a role in alphaDG glycosylation, is a bona fide disease gene in Walker-Warburg syndrome PMID: 23877401
  3. These functional studies identify an important role of B3GNT1 in the synthesis of the uncharacterized laminin-binding glycan of alpha-dystroglycan and implicate B3GNT1 as a novel causative gene for Walker-Warburg syndrome. PMID: 23359570
  4. These results demonstrate that B3GNT1 and B4GALT1 physically associate in vitro and in cultured cells, providing insight into possible mechanisms for regulation of polyLacNAc production. PMID: 19261593
  5. These results identify a previously undescribed role of carbohydrate-dependent cell-basement membrane interaction in tumor suppression and its control by beta3GnT1 and LARGE. PMID: 19587235

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Involvement in disease Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A13 (MDDGA13)
Subcellular Location Golgi apparatus membrane, Single-pass type II membrane protein
Protein Families Glycosyltransferase 49 family
Tissue Specificity In the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocyte
Database Links

HGNC: 15685

OMIM: 605517

KEGG: hsa:11041

STRING: 9606.ENSP00000309096

UniGene: Hs.8526

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