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| Code | CSB-PA002499EA01HU |
| Size | US$299 |
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| Full Product Name | Rabbit anti-Homo sapiens (Human) B4GAT1 Polyclonal antibody | ||||
| Uniprot No. | O43505 | ||||
| Target Names | B4GAT1 | ||||
| Alternative Names | B4GAT1; B3GNT1; B3GNT6; Beta-1,4-glucuronyltransferase 1; I-beta-1,3-N-acetylglucosaminyltransferase; iGnT; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; Poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 | ||||
| Raised in | Rabbit | ||||
| Species Reactivity | Human | ||||
| Immunogen | Recombinant Human Beta-1,4-glucuronyltransferase 1 protein (161-415AA) | ||||
| Immunogen Species | Homo sapiens (Human) | ||||
| Conjugate | Non-conjugated The B4GAT1 Antibody (Product code: CSB-PA002499EA01HU) is Non-conjugated. For B4GAT1 Antibody with conjugates, please check the following table. |
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| Clonality | Polyclonal | ||||
| Isotype | IgG | ||||
| Purification Method | >95%, Protein G purified | ||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
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| Form | Liquid | ||||
| Tested Applications | ELISA, IHC | ||||
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| Protocols | ELISA Protocol Immunohistochemistry (IHC) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1).
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| Gene References into Functions |
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| Involvement in disease | Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A13 (MDDGA13) |
| Subcellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. |
| Protein Families | Glycosyltransferase 49 family |
| Tissue Specificity | In the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocyte |
| Database Links |
HGNC: 15685 OMIM: 605517 KEGG: hsa:11041 STRING: 9606.ENSP00000309096 UniGene: Hs.8526 |
