Recombinant Human N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase(B3GNT1),partial

Code	CSB-YP002499HU1
Size	Pls inquire
Source	Yeast
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Code	CSB-EP002499HU1
Size	Pls inquire
Source	E.coli
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Code	CSB-EP002499HU1-B
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP002499HU1
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP002499HU1
Size	Pls inquire
Source	Mammalian cell
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Product Details
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Target Data

Product Details

Purity	>85% (SDS-PAGE)
Target Names	B4GAT1
Uniprot No.	O43505
Alternative Names	3-N-acetylglucosaminyltransferase 1; 3-N-acetylglucosaminyltransferase; B3GN-T1; B3GN1_HUMAN; B3GNT1; B3GNT6; beta-1,3-N-acetylglucosaminyltransferase bGnT-6; BETA3GNTI; I-beta-1; i-beta-1,3-N-acetylglucosaminyltransferase; iGAT; iGnT; N-acetyllactosaminide beta-1; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; OTTHUMP00000235058; Poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betaGal beta-1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
Species	Homo sapiens (Human)
Protein Length	Partial
Tag Info	The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form	Lyophilized powder
Buffer before Lyophilization	Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs	Protein FAQs
Storage Condition	Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time	Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet	Please contact us to get it.

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Target Data

Function	Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan
Gene References into Functions	B4GAT1 is involved in the initiation of the LARGE-dependent repeating disaccharide that is necessary for extracellular matrix protein binding to O-mannosylated alpha-dystroglycan. PMID: 25279697 report describes the first truncating mutation in B3GNT1 and confirms that this gene, which plays a role in alphaDG glycosylation, is a bona fide disease gene in Walker-Warburg syndrome PMID: 23877401 These functional studies identify an important role of B3GNT1 in the synthesis of the uncharacterized laminin-binding glycan of alpha-dystroglycan and implicate B3GNT1 as a novel causative gene for Walker-Warburg syndrome. PMID: 23359570 These results demonstrate that B3GNT1 and B4GALT1 physically associate in vitro and in cultured cells, providing insight into possible mechanisms for regulation of polyLacNAc production. PMID: 19261593 These results identify a previously undescribed role of carbohydrate-dependent cell-basement membrane interaction in tumor suppression and its control by beta3GnT1 and LARGE. PMID: 19587235 Show More Hide All
Involvement in disease	Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A13 (MDDGA13)
Subcellular Location	Golgi apparatus membrane, Single-pass type II membrane protein
Protein Families	Glycosyltransferase 49 family
Tissue Specificity	In the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocyte
Database Links	HGNC: 15685 OMIM: 605517 KEGG: hsa:11041 STRING: 9606.ENSP00000309096 UniGene: Hs.8526