CEBPB Antibody, Biotin conjugated

Code CSB-PA005181LD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CEBPB Polyclonal antibody
Uniprot No. P17676
Target Names CEBPB
Alternative Names AGP/EBP antibody; C EBP beta antibody; C/EBP beta antibody; C/EBP related protein 2 antibody; CCAAT Enhancer Binding Protein beta antibody; CCAAT/enhancer-binding protein beta antibody; CEBPB antibody; CEBPB_HUMAN antibody; CRP2 antibody; IL 6DBP antibody; IL6DBP antibody; Interleukin 6 dependent binding protein antibody; LAP antibody; Liver activator protein antibody; Liver enriched transcriptional activator antibody; NF IL6 antibody; NFIL6 antibody; Nuclear factor NF IL6 antibody; Nuclear factor NF-IL6 antibody; SF B antibody; SFB antibody; Silencer factor B antibody; TCF-5 antibody; TCF5 antibody; Transcription factor 5 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human CCAAT/enhancer-binding protein beta protein (41-270AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Important transcription factor regulating the expression of genes involved in immune and inflammatory responses
Gene References into Functions
  1. CEBPbeta enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation. PMID: 29712898
  2. Our data suggest that activation of the GPR91-ERK1/2-C/EBP beta (c-Fos, HIF-1a) signaling pathway plays a tonic role in regulating VEGF transcription in rat retinal ganglion cells. PMID: 28374767
  3. C/EBPbeta contributes to all-trans retinoic acid-induced activation of NEAT1 during acute promyelocytic leukemia cell differentiation. PMID: 29111326
  4. Palmitate can induce lipid accumulation in HepG2 cells by activating C/EBPbeta-mediated G0S2 expression. PMID: 29209111
  5. Anti-tumor effect of Rg3, which is mediated by inhibition of C/EBPbeta/NF-kappaB signaling. PMID: 29169725
  6. C/EBPbeta upregulation promoted tumor cell invasion in an MMP3-dependent manner in vitro and was associated with metastatic status in colorectal cancer PMID: 29172775
  7. findings support the hypothesis that maternal diabetes-induced ER stress increases CHOP expression which represses PGC-1alpha through suppressing the C/EBPbeta transcriptional activity, subsequently induces mitochondrial dysfunction and ultimately results in NTDs PMID: 28482072
  8. Studies indicate that CCAAT enhancer binding protein beta (C/EBPB)-transcription factor CITED4 (CITED4) signaling is a pathway in cardioprotection mediating benefits of exercise in heart. PMID: 29098625
  9. C/EBP beta LAP isoform expression was increased and LIP/TNFAIP3/TNIP1 expression was decreased in systemic lupus erythematosus (SLE) patients. LAP expression was positively correlated with SLE disease activity; TNFAIP3 and TNIP1 expression was negatively correlated with SLE disease activity. PMID: 27659348
  10. Overexpression of C/EBPbeta-1 increases transformation, upregulates expression of the cancer stem cell marker ALDH1A1, and leads to chemoresistance. PMID: 28148901
  11. Elevated expression of CEBPB were associated with a decreased risk of hepatocellular carcinoma. PMID: 28321907
  12. C/EBPbeta overexpression or knockdown did not change the levels of IL-1beta-induced SOCS1. SOCS1 regulated the levels of C/EBPbeta mRNA by ubiquitination of C/EBPbeta as well as transcriptional regulation in human chondrocytes. PMID: 27339399
  13. C/EBPbeta suppresses miR-17-92 via two pathways - indirectly through induction of PU.1 expression, where it functions as an activator, and more efficiently, through direct interaction with the miR-17-92 promoter. PMID: 26868909
  14. p300-dependent histone H3 acetylation and C/EBPbeta-regulated IKKbeta expression contribute to thrombin-induced IL-8/CXCL8 expression in human lung epithelial cells. PMID: 28428115
  15. C/EBPbeta negatively regulates PR-B expression in glioblastoma cells. PMID: 27663075
  16. High CEBPB expression is associated with recurrence in Glioma. PMID: 28754668
  17. Study results show the role of WT1 in regulating decidualization in human endometrial stromal cells. C/EBPbeta is an upstream gene that regulates WT1 expression by binding to the novel enhancer region. PMID: 28977591
  18. EGFR and C/EBP-beta oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-beta isoform PMID: 27572958
  19. expressed in intervertebral discs PMID: 26505752
  20. Data show that in an in vitro acute lung injury model established by lipopolysaccharide induction, phosphorylation of C/EBP beta was decreased and bioinformatics analysis discovered a putative binding site of C/EBP beta in CCSP1 promoter; LPS stimulation reduced C/EBP beta phosphorylation and suppressed the transcription of CCSP1. PMID: 28760550
  21. Increased polyamine metabolism in CRC could be driven by c-Myc and C/EBPbeta rather than Bacteroides fragilis infection. PMID: 27433286
  22. A transcription factor complex consisting of ATF6 (an endoplasmic reticulum-resident factor) and C/EBP-beta is required for the IFN-gamma-induced expression of DAPK1 IFN-gamma-induced proteolytic processing of ATF6 and phosphorylation of C/EBP-beta are obligatory for the formation of this transcriptional complex PMID: 27590344
  23. Data show that CCAAT/enhancer-binding protein beta (C/EBP beta) expression is increased in endothelial cells and retinal pigment epithelial cells infected by Toxoplasma gondii, resulting in the activation of autophagy in host cells by inhibiting mechanistic target of rapamycin protein (mTOR) pathway. PMID: 28092463
  24. Data suggest that melatonin down-regulates adipogenesis via reduction of (a) cAMP synthesis, (b) reactive oxygen species synthesis, (c) phosphorylation of CEBPB (CCAAT-enhancer-binding protein-beta), and (d) activation of GSK3B (glycogen synthase kinase 3 beta); primary mesenchymal stem cells cultured in adipogenic differentiation media were used in these studies. PMID: 26797706
  25. we concluded that staurosporine enhanced ATRAinduced granulocytic differentiation in U937 cells via MEK/ERK-mediated modulation of the protein level of C/EBPs PMID: 27665842
  26. C/EBPbeta-Thr217 phosphorylation is essential for the activation of the inflammasome in liver macrophages and for the hepatocyte apoptosis induced by hepatotoxins that results in liver injury. PMID: 27067260
  27. The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN, CEBPB, PRKCB, ENO2, or CEBPG) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset. PMID: 27495086
  28. The increase of nuclear C/EBPbeta protein was dependent on p38. PMID: 27833915
  29. ER stress appears to play a regulatory role in the inflammatory response and extracellular matrix degradation in human periodontal ligament cells in response to LPS stimuli by activating C/EBP beta expression. PMID: 27011164
  30. our data demonstrate that C/EBPbeta plays a central role in controlling Gadd45beta gene expression in articular chondrocytes PMID: 26896926
  31. CREB is a transcriptional regulator of C/EBPbeta in gastric cancer cells. PMID: 25740226
  32. C/EBPbeta and NFkappaB inhibition by melatonin may impede both gastric tumor growth and peritoneal dissemination by inducing ER stress and inhibiting EMT. PMID: 26514342
  33. C/EBPbeta promotes autophagy in PC3 cells by augmenting REDD1 expression. PMID: 26968249
  34. TNF-a induced MMP1/3 expression, which was abrogated by C/EBPb knockdown or p38 MAPK inhibition. PMID: 25959126
  35. Loss of C/EBPbeta expression in primary myoblasts rescues differentiation under cachectic conditions without restoring myotube size, indicating that C/EBPbeta is an important inhibitor of myogenesis in cancer cachexia. PMID: 26709824
  36. Letter: elevated C/EBPbeta in advanced COPD may be an indication of a breakdown of regulatory mechanisms and excessive inflammation. PMID: 26511475
  37. the oxidative stress-induced overexpression of C/EBPbeta might influence the activity of MMPs by regulating the Wnt/beta-catenin signaling pathway to affect the invasion of trophoblast cells, and participate in the pathogenesis of preeclampsia. PMID: 26166436
  38. This study established a correlation between miR-155 and TLR7 during hepatitis B virus infection and also demonstrated in vitro that increased miR-155 level could help to reduce viral load by targeting C/EBP-beta. PMID: 25720442
  39. Low CEBPB expression is associated with metastasis in hepatocellular carcinoma. PMID: 25965830
  40. Global profiling in human mesenchymal stem cells and a novel cell-free assay reveals that ATF4 requires C/EBPbeta for genomic binding at a motif distinct from that bound by the C/EBPbeta homodimer. PMID: 26111340
  41. High CEBPB expression is associated with prostate cancer. PMID: 25772238
  42. C/EBPbeta could promote the invasion and migration of human renal carcinoma 786-O cells, and had an inducing effect on nuclear translocation of NF-kappaB in 786-O cells. PMID: 26522356
  43. C/EBPbeta induces growth arrest in a colorectal cancer cell line and that its expression is negatively correlated with the miR-191 level in patient samples. PMID: 25784653
  44. CCAAT/enhancer binding protein beta is dispensable for development of lung adenocarcinoma. PMID: 25767874
  45. C/EBPbeta was the main regulator of P2X7 receptor expression in response to a glucose challenge. C/EBPalpha and the C/EBPbeta-LIP isoform blocked the C/EBPbeta-dependent regulation of P2X7 receptor transcription. PMID: 25403356
  46. these studies show that C/EBPbeta increases S100A4 levels by directly activating S100A4 promoter expression in glioblastoma cells and provide evidence that S100A4 may contribute to the C/EBPbeta-induced invasiveness. PMID: 25738360
  47. EGF up-regulates miR-31 through the C/EBPbeta signal cascade in oral carcinoma PMID: 25229239
  48. The results found that C/EBP-beta is an important transcription factor within the metabolic disturbances of the metabolic system. PMID: 25699273
  49. C/EBPbeta, especially C/EBPbeta-LIP in cooperation with ATF4, is involved in osteoclast formation by regulating RANKL expression in RA-FLS. These findings suggest that C/EBPbeta plays a crucial role in bone destruction in RA joints PMID: 25811130
  50. The C/EBPbeta transcription factor plays a role in hematological malignancies of both myeloid and lymphoid lineage origin. [Review] PMID: 25940801
  51. Associations between CEBPB expression in blood and muscle strength may be consistent with the CEBPB-dependent muscle repair process. PMID: 25391587
  52. revealed a new regulatory mechanism that involves CCAAT-enhancer-binding protein beta-LIP-mediated downregulation of miR-203, which plays a key role in epithelial-mesenchymal transition and metastasis PMID: 24994936
  53. Altered PRKRA signalling and C / EBPbeta expression is associated with HLA-B27 expression in monocytic cells. PMID: 21988375
  54. Results shed some light on the mechanisms promoted by EGFRvIII that contribute to the malignant microenvironment in glioblastoma and identified that C/EBPb increased IL-6-driven angiogenesis and thereby glioblastoma progression. PMID: 25382637
  55. Spontaneous and drug-selected MDR cells lack LIP, which is eliminated by ubiquitin-mediated degradation. Loss of LIP drives MDR not only by increasing Pgp expression but also by a two-fold attenuation of ER stress-triggered cell death. PMID: 25766403
  56. Advances toward elucidation of the function and roles of the post-translational modification of C/EBPbeta during adipogenesis will greatly improve our understanding of the molecular mechanisms governing adipogenesis. PMID: 25451943
  57. Irf8 forms a negative feedback loop with Cebpb, a monocyte-derived DC epigenetic fate-determining transcription factor. PMID: 25453760
  58. C/EBPbeta is an important mediator of galectin-7 gene activation in breast cancer cells PMID: 24789216
  59. Data show that oroxylin A inhibits the all-trans-Retinoic Acid (ATRA)-induced IL-6 production via downregulating transcription factor CHOP in leukemia cell lines, suggesting a therapeutic strategy for retinoic acid syndrome (RAS). PMID: 25192658
  60. we propose that upregulation of C/EBPs in the AD brain could be an important orchestrator of pathogenic changes. PMID: 24466171
  61. a molecular basis for S1P-induced transcriptional activation of CRP and its functional significance in the acquisition of the invasive phenotype of human breast epithelial cells under inflammatory conditions PMID: 23955082
  62. C/EBPbeta is an important mediator of progesterone production by working together with SF-1, especially under tropic hormone-stimulated conditions PMID: 24635384
  63. findings showed that independent C/EBPbeta 3'-UTR RNA exists in many human tissues and cells PMID: 24222641
  64. Increased expression of c-Jun and C/EBPbeta was associated with upregulation of ETB receptor expression in rat retinas in response to elevated IOP. PMID: 24265756
  65. Pro-inflammatory cytokine induction of 11beta-hydroxysteroid dehydrogenase type 1 in A549 cells requires phosphorylation of C/EBPbeta at Thr235. PMID: 24086653
  66. C/EBPbeta implicated as a downstream target of ERK1/2. PMID: 24086495
  67. loss of BRM epigenetically induces C/EBPbeta transcription, which then directly induces alpha5 integrin transcription to promote the malignant behavior of mammary epithelial cells PMID: 23770848
  68. Among the three isoforms of C/EBPbeta, C/EBPbeta LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. PMID: 24589738
  69. Deletion/mutagenesis of C/EBP-beta binding motif of DPP III promoter significantly increased its activity and abolished its responsiveness to IL-6 in glioblastoma cells. PMID: 24472318
  70. Study was done to identify target genes of transcription factor CCAAT enhancer-binding protein beta (CEBPB) in acute promyelocytic leukemia cells induced by all-trans retinoic acid. PMID: 23711709
  71. We demonstrate that stimulatory signals can change the DNA methylation status at a CCAAT/enhancer binding protein (CEBP) binding site and a transcription start site and activate expression of the angiotensinogen gene (AGT). PMID: 24191285
  72. C/EBPbeta regulates the expression of IGFBP-1 and PRL by altering the histone acetylation status of their promoters but differently regulates Mn-SOD gene expression in human ESC during decidualization PMID: 24248464
  73. The results identify miR-155-mediated loss of C/EBPbeta as a mechanism, which promotes breast cancer progression by shifting the TGF-beta response from growth inhibition to EMT, invasion and metastasis. PMID: 23955085
  74. C/EBPbeta-regulated proteins BCL2A1, G0S2 and DDX21 play a crucial role in survival and proliferation of ALK+ anaplastic large cell lymphoma cells. PMID: 23741337
  75. Isoniazid suppresses antioxidant response element activity and expression of C/EBPbeta and C/EBPdelta during early stage of adipogenesis. PMID: 24128855
  76. MUC1-C (i) activates a previously unrecognized ERK-->C/EBPbeta-->ALDH1A1 pathway, and (ii) promotes the induction of ALDH activity in breast cancer cells. PMID: 24043631
  77. An isoform of C/EBPbeta, liver-enriched inhibitory protein (LIP), is identified as a previously unrecognized transcriptional regulator of CXCR4 in breast cancer cells. PMID: 23966000
  78. Authors conclude the regulation of both C/EBPbeta gene expression and C/EBPbeta-LIP and C/EBPbeta-LAP protein turn-over plays an important role for the expression of adipogenic regulators and/or adipocyte differentiation genes in early adipogenic differentiation of human adipose-derived stromal/progenitor cells and at later stages in human immature adipocytes. PMID: 23314288
  79. data provide evidence for CS/GH-V dysregulation in acute HFD-induced obesity in mouse pregnancy and chronic obesity in human pregnancy and implicate C/EBPbeta, a factor associated with CS regulation and placental development PMID: 23782703
  80. Demonstration of alternative translation initiation in mouse PMID: 1934061
  81. mutational studies of mouse ortholog demonstrating alternative translational initiation PMID: 11452034
  82. CEBPbeta could be an important gene in acute promyelocytic leukemia pathogenesis PMID: 14976428
  83. C/EBPbeta as a direct substrate of G9a-mediated post-translational modification that alters the functional properties of C/EBPbeta during gene regulation. PMID: 18647749
  84. USF2 functionally interacts with YY1 blocking its inhibitory activity, in favor of CEBPB transactivation. PMID: 23560079
  85. these findings revealed a novel functional link between C/EBPbeta and STAT3 that is a critical regulator of endometrial differentiation in women. PMID: 23097472
  86. C/EBPbeta regulates interleukin (IL)-1beta astrocytic inflammatory genes. PMID: 22818222
  87. The LIP isoform of CEBPB mediates a non-apoptotic cell death process via engulfment of neighboring cells. PMID: 22860016
  88. In prostate cancer cells, S100A8 expression is stimulated by prostaglandin E2 via EP2 and EP4 receptors through activation of the protein kinase A signaling pathway and stimulation of CCAAT/enhancer-binding-protein-beta binding to the S100A8 promoter. PMID: 22728165
  89. we identified the differentiation-associated transcription factor CCAAT/enhancer binding protein beta as a critical regulator of CCL20 gene expression in normal human keratinocytes. PMID: 22911498
  90. these results provide evidence that the cancer cell growth suppression by this 62nt RNA containing AU-rich elements may be due to competitive binding to HuR. PMID: 22921787
  91. We showed that C/EBPbeta interacts with the proximal promoter of the gene ABCC6. PMID: 22763786
  92. hepatitis C virus induced an increase in activation of the major gluconeogenic transcription factors including CEBPB, promoting gluconeogenic gene expression. PMID: 22955269
  93. study demonstrates that the Src/Stat3 and C/EBP signaling pathways positively regulate the expression of the Jab1 oncogene; results show that Stat3 and LAP2 (C/EBP-beta2) are the two major transcription factors that contribute to Jab1 overexpression that leads to increased proliferation of breast cancer cells PMID: 21689417
  94. both expanded limbal NCs and HUVEC rejoined with LEPC to form spheres to upregulate expression of DeltaNp63alpha, CK15, and CEBPdelta, the former but not the latter abolished expression of CK12 keratin. PMID: 22538425
  95. C/EBP-beta target genes in monocytic cells are summarized and resulting functions are described, including regulation of proliferation and differentiation as well as orchestration of processes of mainly the innate immune response. [review] PMID: 22374303
  96. knockdown of C/EBPbeta isoforms blocks activation of human papillomavirus (HPV) late gene expression from complete viral genomes upon differentiation. PMID: 22379085
  97. finding that raised CEBPB expression in circulating leukocyte-derived RNA samples in vivo is associated with greater muscle strength and better physical performance in humans PMID: 22152057
  98. A striking activity of C/EBP is imaged predominantly in the brain of living C/EBP-luc transgenic mice in response to lipopolysaccharide, showing for the first time in vivo that C/EBP mediates the brain response to inflammation. PMID: 21545825
  99. Physical interaction is confirmed between human remodeling subunit RSF proteins C/EBPbeta, chromatin remodeling protein SNF2H, and apobec-1 complementation factor ACF1. PMID: 22242598
  100. Sumolylation of C/EBPbeta1 in breast cancer cells may be a mechanism to circumvent oncogene-induced senescence. PMID: 21980398

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Subcellular Location Nucleus, Cytoplasm
Protein Families BZIP family, C/EBP subfamily
Tissue Specificity Expressed at low levels in the lung, kidney and spleen.
Database Links

HGNC: 1834

OMIM: 189965

KEGG: hsa:1051

STRING: 9606.ENSP00000305422

UniGene: Hs.517106

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