CEBPB Antibody

Datasheet
Code CSB-PA005181LA01HU
See More Details Free Antibody trial simple
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Uniprot No. P17676
Image
  • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA005181LA01HU at dilution of 1:100

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human CCAAT/enhancer-binding protein beta protein (41-270AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Relevance Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis (By similarity).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5), CEBPB, TCF5
Immunogen Species Human
Research Area Others
Target Names CEBPB
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Important transcription factor regulating the expression of genes involved in immune and inflammatory responses
Subcellular Location Nucleus, Cytoplasm
Protein Families BZIP family, C/EBP subfamily
Tissue Specificity Expressed at low levels in the lung, kidney and spleen.
Database Links

HGNC: 1834

OMIM: 189965

KEGG: hsa:1051

STRING: 9606.ENSP00000305422

UniGene: Hs.517106

Pathway TNF signaling pathway
IL-17 signaling pathway

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