COX7A1 Antibody

Code CSB-PA005860GA01HU
Size US$685 How to order?
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Product Details

Uniprot No. P24310
Target Names COX7A1
Alternative Names COX7A antibody; COX7A1 antibody; COX7AH antibody; COX7AM antibody; CX7A1_HUMAN antibody; Cytochrome c oxidase subunit 7A1 antibody; Cytochrome c oxidase subunit 7A1 mitochondrial antibody; Cytochrome c oxidase subunit VIIa H antibody; Cytochrome c oxidase subunit VIIa heart antibody; Cytochrome c oxidase subunit VIIa heart/muscle isoform antibody; Cytochrome c oxidase subunit VIIa M antibody; Cytochrome c oxidase subunit VIIa muscle antibody; Cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) antibody; Cytochrome c oxidase subunit VIIa polypeptide 1 antibody; Cytochrome c oxidase subunit VIIa-H antibody; Cytochrome c oxidase subunit VIIa-heart antibody; Cytochrome c oxidase subunit VIIa-M antibody; Cytochrome c oxidase subunit VIIa-muscle antibody; mitochondrial antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Human COX7A1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Gene References into Functions
  1. COX7A1 is a novel gene that might play a crucial role in the etiology of lung adenocarcinoma and can serve as a biomarker for lung cancer disease progression PMID: 27866983
  2. promoter contains and is regulated by sequence elements typical of contractile muscle as well as the element for the common transcription factor Sp1 PMID: 11997101
  3. While DNA methylation of the COX7A1 promoter was increased in muscle from elderly compared with young twins, the opposite was found for COX7A1 mRNA expression PMID: 18488190
Subcellular Location Mitochondrion inner membrane; Single-pass membrane protein.
Protein Families Cytochrome c oxidase VIIa family
Database Links

HGNC: 2287

OMIM: 123995

KEGG: hsa:1346

STRING: 9606.ENSP00000292907

UniGene: Hs.421621

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