DGKH Antibody

1. This sstudy shown that the highest expression levels of DGKH in the human brain were found in the striatum. PMID: 27085324
2. DGKH is a replicated risk gene of bipolar disorder (BD). PMID: 27016658
3. several single variants and genes showed strong association with Panic Disorders, where DGKH was found to be the strongest Panic Disorder associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. PMID: 27255576
4. DGKeta-Pleckstrin Homology Domain preferentially interacts with Phosphatidylinositol 4,5-Bisphosphate and has crucial roles in regulating the subcellular localization and physiological function of DGKeta. PMID: 26887948
5. This study demonstrated that significant association of the DGKH risk haplotype with increased amygdala volume in Bipolar disorder, but not in schizophreia or healthy controls. PMID: 24958494
6. These findings implicate a link between nucleotide variant of DGKH and a cause for a complex-trait disease, calcium oxalate stone PMID: 25081328
7. DGKK variants are associated with hypospadias PMID: 23177175
8. expressions of DGKeta and DGKzeta were increased and decreased, respectively, whereas those of DGKgamma and DGKepsilon remained unchanged. This is the first report that describes the differential regulation of DGK isoforms in normal and failing human hearts. PMID: 21548979
9. Differential effects of DGKH in healthy controls vs the bipolar high-risk group manifest as a failure to disengage default-mode regions in those at familial risk carrying the risk haplotype. PMID: 22048461
10. Four DGKH markers are linked to adult attention-hyperactivity disorder and seven to unipolar depression, making DGKH a risk factor gene for bipolar disorder, unipolar depression and adult attention-deficit hyperactivity disorder. PMID: 21654738
11. Increased gene expression of diacylglycerol kinase eta is found in brain tissue from patients with bipolar disorder. PMID: 20519059
12. Although the association was not strong, the result of this study would support the association between DGKH and BD. PMID: 21507135
13. The results of tisd support DGKH as shared risk factor of bipolar disorder and schizophrenia in the Chinese Han population. PMID: 20733578
14. No significant association after multiple-testing correction between any of the single nucleotide polymorphisms in DGKH and bipolar disorder, was found. PMID: 19478689
15. While negative, our findings do not exclude an involvement of DGKH and NR1D1 in lithium prophylaxis. PMID: 19818381
16. alternative splicing of the human DGK eta gene generates at least two isoforms with distinct biochemical and cell biological properties responding to different cellular metabolic requirements PMID: 12810723
17. diacylglycerol kinase eta (DGKH) is association in the etiology of bipolar disorder. PMID: 17486107
18. DGKeta acts as a novel critical regulatory component of the Ras/B-Raf/C-Raf/MEK/ERK signaling cascade via a previously unidentified mechanism. PMID: 19710016

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HGNC: 2854

OMIM: 604071

KEGG: hsa:160851

STRING: 9606.ENSP00000337572

UniGene: Hs.630380