DGKH Antibody

Code CSB-PA054492
Size US$297
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  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using DGKH antibody.
  • Immunofluorescence analysis of HeLa cells, using DGKH antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DGKH Polyclonal antibody
Uniprot No.
Target Names
DGKH
Alternative Names
DGKHDiacylglycerol kinase eta antibody; DAG kinase eta antibody; EC 2.7.1.107 antibody; Diglyceride kinase eta antibody; DGK-eta antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human DGKH.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,IHC,IF
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
Gene References into Functions
  1. This sstudy shown that the highest expression levels of DGKH in the human brain were found in the striatum. PMID: 27085324
  2. DGKH is a replicated risk gene of bipolar disorder (BD). PMID: 27016658
  3. several single variants and genes showed strong association with Panic Disorders, where DGKH was found to be the strongest Panic Disorder associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. PMID: 27255576
  4. DGKeta-Pleckstrin Homology Domain preferentially interacts with Phosphatidylinositol 4,5-Bisphosphate and has crucial roles in regulating the subcellular localization and physiological function of DGKeta. PMID: 26887948
  5. This study demonstrated that significant association of the DGKH risk haplotype with increased amygdala volume in Bipolar disorder, but not in schizophreia or healthy controls. PMID: 24958494
  6. These findings implicate a link between nucleotide variant of DGKH and a cause for a complex-trait disease, calcium oxalate stone PMID: 25081328
  7. DGKK variants are associated with hypospadias PMID: 23177175
  8. expressions of DGKeta and DGKzeta were increased and decreased, respectively, whereas those of DGKgamma and DGKepsilon remained unchanged. This is the first report that describes the differential regulation of DGK isoforms in normal and failing human hearts. PMID: 21548979
  9. Differential effects of DGKH in healthy controls vs the bipolar high-risk group manifest as a failure to disengage default-mode regions in those at familial risk carrying the risk haplotype. PMID: 22048461
  10. Four DGKH markers are linked to adult attention-hyperactivity disorder and seven to unipolar depression, making DGKH a risk factor gene for bipolar disorder, unipolar depression and adult attention-deficit hyperactivity disorder. PMID: 21654738
  11. Increased gene expression of diacylglycerol kinase eta is found in brain tissue from patients with bipolar disorder. PMID: 20519059
  12. Although the association was not strong, the result of this study would support the association between DGKH and BD. PMID: 21507135
  13. The results of tisd support DGKH as shared risk factor of bipolar disorder and schizophrenia in the Chinese Han population. PMID: 20733578
  14. No significant association after multiple-testing correction between any of the single nucleotide polymorphisms in DGKH and bipolar disorder, was found. PMID: 19478689
  15. While negative, our findings do not exclude an involvement of DGKH and NR1D1 in lithium prophylaxis. PMID: 19818381
  16. alternative splicing of the human DGK eta gene generates at least two isoforms with distinct biochemical and cell biological properties responding to different cellular metabolic requirements PMID: 12810723
  17. diacylglycerol kinase eta (DGKH) is association in the etiology of bipolar disorder. PMID: 17486107
  18. DGKeta acts as a novel critical regulatory component of the Ras/B-Raf/C-Raf/MEK/ERK signaling cascade via a previously unidentified mechanism. PMID: 19710016

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Subcellular Location
Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli (PubMed:12810723). Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association (PubMed:12810723). Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS (PubMed:19710016).
Protein Families
Eukaryotic diacylglycerol kinase family
Tissue Specificity
[Isoform 1]: Expressed only in testis, kidney and colon.; [Isoform 2]: Ubiquitously expressed.
Database Links

HGNC: 2854

OMIM: 604071

KEGG: hsa:160851

STRING: 9606.ENSP00000337572

UniGene: Hs.630380

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