DLGAP5 Antibody

Code CSB-PA002993
Size US$100
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  • Western Blot analysis of A549 cells using HURP Polyclonal Antibody
  • Western Blot analysis of K562 NIH-3T3 cells using HURP Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
DAP-5 antibody; DAP5 antibody; Discs large homolog 7 antibody; Disks large associated protein 5 antibody; Disks large associated protein DLG7 antibody; Disks large-associated protein 5 antibody; Disks large-associated protein DLG7 antibody; DLG 1 antibody; DLG 7 antibody; DLG1 antibody; DLG7 antibody; DLGAP5 antibody; DLGP5_HUMAN antibody; Drosophila discs large 1 tumor suppressor like antibody; Hepatoma up regulated protein antibody; Hepatoma up-regulated protein antibody; Hepatoma upregulated protein antibody; HURP antibody; KIAA0008 antibody
Raised in
Species Reactivity
Synthesized peptide derived from the C-terminal region of Human HURP.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
Gene References into Functions
  1. The bioinformatic analysis suggests that HURP promotes carcinogenesis in multiple manners. Taken together, we revealed the prognostic value of HURP in nonsmall cell lung cancer (NSCLC)patients and HURP may be a potential therapeutic target for NSCLC. PMID: 29484418
  2. Data provide evidence for the involvement of HURP protein in the modulation of prostate cancer cell resistance to gamma irradiation via mechanism mediated by the ubiquitination of ATM and p53. PMID: 26505164
  3. Aurora-A/HURP relays cell transforming signal to NF-kappaB, and the HURP/NF-kappaB complex is engaged in the regulation of cyclin E1 expression. PMID: 25289861
  4. Detection of urinary HURP RNA is a useful for early detection of bladder cancer and bilharzial bladder cancer. PMID: 24375315
  5. expression of DLG7, a hypoxia-controlled gene, holds prognostic potential in high-risk CaP; this also demonstrates that variation of oxygen tension may constitute a tool for identification of novel biomarkers for CaP. PMID: 24349376
  6. The expression of DLGAP5 is regulated by methylation; the up-regulation of DLGAP5 contributes to hepatocellular carcinoma tumorigenesis by promoting cell proliferation. PMID: 24324629
  7. RNA purification using functionalized MNPs was 97%. CONCLUSIONS: The developed colorimetric HURP RNA AuNP assay is sensitive, simple, and can aid noninvasive diagnosis of bladder cancer PMID: 24183881
  8. HURP is a substrate of Aurora kinase A, which plays a crucial role in the stabilization of kinetochore fiber PMID: 23610398
  9. Knockdown of HURP inhibits the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and accumulation of p53. PMID: 22230478
  10. Hepatocellular carcinoma patients can be separated into three prognosis-distinguishable groups by use of a risk score that is based upon HURP expression. PMID: 22022601
  11. HURP regulates Kif18A localization and dynamics at the plus end of kinetochore microtubules. PMID: 21924616
  12. DLGAP5-PINK1 and BUB1B-PINK1 were strong predictors of disease-free survival and overall survival, respectively, among adult patients with ACT. PMID: 22048964
  13. results strongly suggest that HURP is a potential novel cell cycle regulator that may play a role in the carcinogenesis of human cancer cells PMID: 12527899
  14. Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis is regulated by Fbx7 and the SCF complex PMID: 15145941
  15. KIAA0008 expression is associated with invasiveness of HCC; overexpression of KIAA0008 leads to a more invasive phenotype of HCC cell lines. PMID: 15340842
  16. HURP is a potential oncogenic target of Aurora-A. PMID: 15987997
  17. HURP controls spindle stability and dynamics to achieve efficient kinetochore capture at prometaphase, timely chromosome congression to the metaphase plate, and proper interkinetochore tension for anaphase initiation. PMID: 16769820
  18. Dlg7 has a role in stem cell survival, in maintaining stem cell properties, and in carcinogenesis. PMID: 17322106
  19. Phosphorylation of HURP by Aurora A provides a regulatory mechanism for the control of spindle assembly and function. PMID: 18321990
  20. Combined expression of DLG7 and PINK1 was the best predictor of disease free survival in malignant adrenal cortex neoplasms. PMID: 19139432

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Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
Protein Families
SAPAP family
Tissue Specificity
Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
Database Links

HGNC: 16864

OMIM: 617859

KEGG: hsa:9787

STRING: 9606.ENSP00000247191

UniGene: Hs.77695

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