FOXP1 Antibody

Code CSB-PA008841EA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Western Blot
    Positive WB detected in: Jurkat whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate, Raji whole cell lysate
    All lanes: FOXP1 antibody at 4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 76, 68, 77, 13, 67, 78 kDa
    Observed band size: 90 kDa

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA008841EA01HU at dilution of 1:100

  • Immunofluorescence staining of Hela cells with CSB-PA008841EA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

  • Chromatin Immunoprecipitation Hela (1.1*106) were cross-linked with formaldehyde, sonicated, and immunoprecipitated with 4µg anti-FOXP1 or a control normal rabbit IgG. The resulting ChIP DNA was quantified using real-time PCR with primers (CSB-PP008841HU) against the HSP90B promoter.

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) FOXP1 Polyclonal antibody
Uniprot No. Q9H334
Target Names FOXP1
Alternative Names 12CC4 antibody; FLJ23741 antibody; Fork head related protein like B antibody; Forkhead box P1 antibody; Forkhead box protein P1 antibody; FOX P1 antibody; FOXP 1 antibody; foxp1 antibody; FOXP1_HUMAN antibody; Glutamine rich factor 1 antibody; hFKH1B antibody; HSPC215 antibody; MGC12942 antibody; MGC88572 antibody; MGC99551 antibody; QRF 1 antibody; QRF1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Forkhead box protein P1 protein (1-114AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC, IF, ChIP
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
IF 1:200-1:500
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Native Chromatin Immunoprecipitation(ChIP) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Transcriptional repressor
Gene References into Functions
  1. Co-occurrence of mutations in FOXP1 and PTCH1 in a girl with extreme megalencephaly, callosal dysgenesis and profound intellectual disability. PMID: 30181650
  2. miR-29b recedes the progression of multiple myeloma (MM) via downregulating FOXP1, which may provide a potential biological target for MM treatment. PMID: 30068241
  3. The tumour suppressors FOXP1 and NKX3.1, strongly implicated in PCa development, were identified as key transcription factors regulating TPbeta expression through Prm3 in both PCa cell lines. PMID: 28890397
  4. The findings, in addition to expanding the molecular spectrum of FOXP1 mutations, emphasize the emerging role of WGS in identifying small balanced chromosomal rearrangements responsible for neurodevelopmental disorders and not detected by conventional cytogenetics. PMID: 29969624
  5. MiR-92a may act as a tumor inducer in OSCC by suppressing FOXP1 expression. PMID: 29772443
  6. the varients of FOXP1 and FOXF1 genes are functionally associated with oesophageal adenocarcinoma in Chinese population. PMID: 29666340
  7. Results show that FOXP1 acts as the functional protein of SNHG12. Its expression is regulated by SNHG12 and miR-101-3p in glioma cells. PMID: 30098431
  8. Having a SNP in the FOXP1 gene in the absence of Reflux symptoms had an odds ratio of developing Barrett's esophagus of 1.5. PMID: 29713984
  9. FOXP1 expression is epigenetically regulated by PRMT5. PMID: 29262329
  10. we have identified a novel de novo missense variant in FOXP1 that is identical to the most well-studied etiological variant in FOXP2. Functional characterization revealed clear similarities between these equivalent mutations in terms of their impact on protein function. PMID: 28741757
  11. FOXP1-related intellectual disability syndrome (ID) is a recognisable entity with wide clinical spectrum and frequent systemic involvement; more ID and neuromotor delay, sensorineural hearing loss and feeding difficulties are more common in patients with interstitial 3p deletions versus patients with monogenic FOXP1 defects; Mutations result in impaired transcriptional repression and/or reduced protein stability PMID: 28735298
  12. Prognostic value of decreased FOXP1 protein expression in various tumors, is reported. PMID: 27457567
  13. Blimp1, Foxp1 and pStat3 are expressed in extranodal diffuse large B-cell lymphomas PMID: 27924626
  14. Two rare novel FOXP1 variants associated with a phenotype similar to Mental Retardation with Language Impairment and with or without Autistic Features (MIM 613670). PMID: 28884888
  15. High FOXP1 expression is associated with acute lymphoblastic leukemia. PMID: 27588474
  16. The majority of pathogenic missense and in-frame mutations lie in the DNA-binding domain. The mutations perturb amino acids necessary for binding to the DNA or interfere with the domain swapping that mediates FOXP1 dimerization. PMID: 29090079
  17. Increased frequency of FOXP2 expression significantly correlated with FOXP1-positivity, and FOXP1 co-immunoprecipitated FOXP2 from activated B-cell-diffuse large B-cell lymphoma (ABC-DLBCL) cells. PMID: 27224915
  18. EBV-miR-BART11 plays a crucial role in the promotion of inflammation-induced nasopharyngeal carcinoma (NPC) and gastric cancer (GC) carcinogenesis by directly targeting and inhibiting FOXP1 tumor-suppressive effects. PMID: 27167345
  19. Although the mutant huntingtin gene is expressed widely, neurons of the striatum and cortex are selectively affected in Huntington's disease (HD). Our results suggest that this selectivity is attributable to the reduced expression of Foxp1, a protein expressed selectively in striatal and cortical neurons that plays a neuroprotective role in these cells. PMID: 28550168
  20. the activity of multiple alternate FOXP1 promoters to produce multiple protein isoforms is likely to regulate B-cell maturation. PMID: 27056922
  21. these novel insights into the function of FOXP1 isoforms in controlling the transcriptional program, survival and differentiation of B cells advance our understanding of the role of FOXP1 in lymphomagenesis and further enhance the value of FOXP1 for diagnostics, prognostics, and treatment of DLBCL patients. PMID: 27909217
  22. Data indicate that forkhead box P1 protein (FOXP1) as a target of microRNA miR-92a in primary mediastinal large B-cell lymphoma (PMBL). PMID: 27806315
  23. Results suggest that domain swapping in FoxP1 is at least partially linked to monomer folding stability and follows an unusual three-state folding mechanism, which might proceed via transient structural changes rather than requiring complete protein unfolding as do most domain-swapping proteins PMID: 27276253
  24. these data identify FOXP1 as an essential transcriptional regulator for primary human CD4(+) T cells and suggest its potential important role in the development of PTCL. PMID: 27861791
  25. Kaplan-Meier survival analysis showed that pancreatic ductal adenocarcinoma patients with negative forkhead box P1 and forkhead box O3a expression survived significantly shorter than patients with positive forkhead box P1 and forkhead box O3a expression (p = 0.000). PMID: 28466777
  26. FOXP1 knockdown significantly suppressed growth of HCC cells and induced G1/S phase arrest. PMID: 27618020
  27. FOXP1 has protein-protein interaction with NFAT1 on DNA and enhances breast cancer cell migration by repressing NFAT1 transcriptional activity. PMID: 27859969
  28. FOXP1 functions as an oncogene in promoting cancer stem cell-like characteristics in ovarian cancer cells. PMID: 26654944
  29. The findings highlight that de novo FOXP1 variants are a cause of sporadic intellectual disability and emphasize the importance of this transcription factor in neurodevelopment. PMID: 26647308
  30. we provide supportive evidence that genetic variants at FOXP1, BARX1, and FOXF1 confer risk for the development of EAC. PMID: 26383589
  31. Cell-line derived FOXP1 target genes that were highly correlated with FOXP1 expression in primary DLBCL accurately segregated the corresponding clinical subtypes of a large cohort of primary DLBCL isolates PMID: 26787899
  32. S1PR2 is repressed by FOXP1 in activated B-cell and germinal center B-cell DLBCL cell lines with aberrantly high FOXP1 levels; S1PR2 expression is further inversely correlated with FOXP1 expression in 3 DLBCL patient cohorts. PMID: 26729899
  33. FOXP1 represents a novel regulator of genes targeted by the class II MHC transactivator CIITA and CD74. PMID: 26500140
  34. FOXP1 - novel candidate genes validated in a large case-control sample of schizophrenia. PMID: 26460480
  35. Studied the expression of FOXP1 in colorectal cancer and its potential associations with outcome in colorectal cancer. PMID: 26489674
  36. Authors identified forkhead box protein P1 (FOXP1) as a direct target of miR-504 using microarray analysis and a luciferase assay. PMID: 26854715
  37. FOXP1 is present in normal cells of erythroid and myeloid linages and may have a possible role in development of all hematopoetic cells as well as possible involvement in neoplasm development of myeloid disorders. PMID: 26898077
  38. Over-expression of FOXP1 and SPINK1 may participate in the carcinogenesis of hepatitis B virus related cirrhosis. PMID: 26054682
  39. FOXP1 expression is closely related to the degree of malignancy of epithelial ovarian cancer and may be a reliable index of the chemoresistance and prognosis of ovarian cancer PMID: 25895457
  40. FOXP1 overexpression specifically inhibits formation of IgG- but not IgM-secreting Plasma Cells. PMID: 26289642
  41. integral role for FoxP1 in regulating signaling pathways vulnerable in autism and the specific regulation of striatal pathways important for vocal communication PMID: 26494785
  42. This study demonstrated that Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behavior and mental disorders. PMID: 25266127
  43. Foxp1 mediates programming of limb-innervating motor neurons from mouse and human embryonic stem cells. PMID: 25868900
  44. FOXP1 has a role in potentiating Wnt/beta-catenin signaling in diffuse large B cell lymphoma PMID: 25650440
  45. Data indicate that the mRNA level for forkhead box P1 (FOXP1) and estrogen receptor beta (ERbeta) in ovarian carcinoma tissues decreased, while the expression level of estrogen receptor alpha (ERalpha) mRNA increased. PMID: 25500588
  46. results suggest a novel mechanism in which AR-induced FOXP1 functions as a direct modulator of the AR and FOXA1 centric global transcriptional network. PMID: 25329375
  47. Our results suggest that down-regulation of FOXP1 expression is a common event in high-risk neuroblastoma pathogenesis and may contribute to tumor progression and unfavorable patient outcome. PMID: 25406647
  48. Abnormal expression of FOXP1 in renal cell carcinoma may create progression of tumor from low grade to high grade by regulating the HIF-1-VEGF pathway. PMID: 25778315
  49. The significant expression of FOXP1 may be helpful to some extent in the pathologic diagnosis of cervical mucinous minimal deviation adenocarcinoma PMID: 24908370
  50. Through direct repression of proapoptotic genes, (aberrant) expression of FOXP1 complements (constitutive) NF-kappaB activity to promote B-cell survival and can thereby contribute to B-cell homeostasis and lymphomagenesis. PMID: 25267198
  51. Decreased miR-34a expression and increased FOXP1, p53, and BCL2 coexpression predict poor overall survival for MALT lymphoma and diffuse large B-cell lymphoma patients PMID: 24232982
  52. our results may suggest a possible broader role of FOXP1 in the pathogenesis and progression of myelodysplasia and acute myeloid leukemia. PMID: 24893616
  53. Non-immunoglobulin heavy chain rearrangements of FOXP1 are usually acquired during clinical course of various lymphoma subtypes. PMID: 24416450
  54. miR-150 can influence the relative expression of GAB1 and FOXP1 and the signaling potential of the B-cell receptor PMID: 24787006
  55. Autistic traits and other behavioral problems are likely to be associated with haploinsufficiency of FOXP1 PMID: 24214399
  56. High Foxp1 expression is associated with hepatocarcinoma. PMID: 24211718
  57. data indicate that FoxP1 is essential for the angiogenic function of endothelial cells and functions as a suppressor of the inhibitory guidance cue semaphorin 5B, suggesting A function of FoxP1 in the regulation of neovascularization. PMID: 24023716
  58. Results suggest that haploinsufficiency of FOXP1 is associated with human congenital heart defects. PMID: 23766104
  59. Data suggest that FOXP1 and FOXA1 (forkhead box A1) are primary estrogen receptors alpha (ERalpha) target genes and critical transcription factors that regulate ERalpha activity in breast cancer. [REVIEW] PMID: 23810008
  60. FOXP1 gene expression carries a poor prognosis in thyroid diffuse large B-cell lymphomas. PMID: 22368156
  61. FOXP1 is physiologically downregulated in germinalo center B cells and that aberrant expression of FOXP1 impairs mechanisms triggered by B-cell activation, potentially contributing to B-cell lymphomagenesis. PMID: 23580662
  62. Our data demonstrated the close relationship between FOXP1 nuclear expression and the occurrence of large tumor cells in MALT lymphoma PMID: 22736042
  63. FOXP1 and p65 expression are adverse risk factors in diffuse large B-cell lymphoma PMID: 22809882
  64. Foxp1 is a transcriptional repressor of immune signaling in the central nervous system. PMID: 22492998
  65. Double-positive immunoreactivities of FOXA1 and FOXP1 were significantly associated with a favorable prognosis for the relapse-free and overall survival in with tamoxifen-treated breast cancer. PMID: 22476979
  66. Expression of FoxP1 messenger RNA (mRNA) and protein was significantly higher in NonSmall Cell Lung Carcinoma tissue than in corresponding peritumoral tissue (P = .013 and P < .001, respectively). PMID: 22904134
  67. forkhead box P1 overexpression was associated with an improved overall survival of the patients with peripheral T-cell lymphoma, not otherwise specified PMID: 22401769
  68. A reverse correlation between CTGF and miR-504, miR-504 and FOXP1, and a positive correlation between CTGF and FOXP1 were shown. PMID: 21927029
  69. These results support a role for FOXP1 as an oncogene in hepatocellular carcinoma. PMID: 22422806
  70. FoxP1 is expressed by different cell types in atherosclerotic lesions and associated with more stable plaque characteristics and intraplaque TGFbeta signaling PMID: 21683954
  71. FOXP1 plays an important role in proliferation of breast cancer cells by modulating estrogen signaling. PMID: 21901488
  72. Study shows that tembryonic stem cell (ESC)-specific isoform of FOXP1 stimulates expression of transcription factor genes required for pluripotency, OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. PMID: 21924763
  73. The PAX5-FOXP1 translocation is associated with B-cell acute lymphoblastic leukemia. PMID: 21962897
  74. patients with Non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue that are positive for both PIK3CA and FOXP1 had a worse overall and progression-free survival PMID: 21660567
  75. These data suggest that the opposing transcriptional activities of FoxP1 and Nfat3 maintain cardiomyocyte homeostasis. PMID: 21606195
  76. The results indicate that in cancer cells E2A, FOXO1 and FOXP1 regulate RAG1 and RAG2 expression, which initiates Ig gene rearrangement much in the way similar to B lymphocytes. PMID: 21655267
  77. Myc-mediated repression of microRNA-34a promotes high-grade transformation of B-cell lymphoma by dysregulation of FoxP1. PMID: 21460242
  78. Data show that FOXP1 C61S and C61Y mutants existed as a mixture by NMR analysis. PMID: 21416545
  79. FOXP1 might play a role in the pathogenesis of nodal diffuse large B-cell lymphoma . PMID: 21120478
  80. Overexpression of FOXP1 is present in a considerable proportion of primary cutaneous large B cell lymphoma, leg type and might indicate an unfavourable prognosis. PMID: 21154235
  81. FOXP1 expression negatively correlated with Ki67 expression in clear cell renal cell carcinomas (p = .036). PMID: 21210727
  82. both FOXP1 and FOXP2 are associated with language impairment, but decrease of the former has a more global impact on brain development than that of the latter. PMID: 20950788
  83. Found three heterozygous overlapping deletions solely affecting the FOXP1 gene. All three patients had moderate mental retardation and significant language and speech deficits. PMID: 20848658
  84. FOXP1 overexpression was associated with poor disease-specific survival in all nodal diffuse large B-cell lymphomas. There was no correlation between FOXP1 gene aberrations and either FOXP1 protein expression or survival. PMID: 20579129
  85. Data show a replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1. PMID: 20526340
  86. present in patients with higher clinical stages of chronic lymphocytic leukemia PMID: 19417623
  87. These results demonstrate a role of PKCdelta in alpha(M)beta(2)-mediated Foxp1 regulation in monocytes. PMID: 20190138
  88. Studies illustrated tools for cut-off level determination with prognostic tumor-related biomarkers Bcl-2, Bcl-6, CD10, FOXP1, MUM1, and Cyclin E in DLBCL. PMID: 19925052
  89. Results suggest that FOXP1 demonstrates different expression patterns in familial breast cancers than sporadic tumours, even in tumours showing similar phenotypes, and also suggest a different role of FOXP1 as a tumour suppressor in familial tumours. PMID: 19622517
  90. The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. PMID: 11751404
  91. Foxp1, although broadly expressed, is further regulated by tissue-specific alternative splicing of its functionally important sequence domains PMID: 12692134
  92. complex regulatory mechanism underlying Foxp1, Foxp2, and Foxp4 activity, demonstrating that Foxp1, Foxp2, and Foxp4 are the first Fox proteins reported whose activity is regulated by homo- and heterodimerization PMID: 14701752
  93. FOXP1 and FOXP2 expression patterns in human fetal brain are strikingly similar to those in the songbird, including localization to subcortical structures that function in sensorimotor integration and the control of skilled, coordinated movement PMID: 15056695
  94. FOXP1 is a potential ER coregulator in human breast carcinoma and may also independently regulate additional important pathways that control the progression of breast cancer PMID: 15161711
  95. Integrin engagement regulates monocyte differentiation through FOXP1. PMID: 15286807
  96. This study identifies FOXP1 as a new translocation partner of IGH in a site-dependent subset of MALT lymphomas. PMID: 15703784
  97. Results suggest that FOXP1 expression may be important in diffuse large B-cell lymphoma (DLBCL) pathogenesis. PMID: 15709173
  98. The heterogeneity of FOXP1 expression in germinal centre-derived lymphomas, may have more to do with the transforming events underlying these distinct types of lymphoma than with their common origin. PMID: 16200457
  99. Tumors with exclusively cytoplasmic expression of FOXP1 were linked with deep myometrial invasion. PMID: 16258506
  100. FOXP1 expression is an independent prognostic factor in MALT lymphomas. A subgroup of nongerminal center DLBCLs (Diffuse Large B-Cell Lymphomas, those marked by FOXP1 expression and trisomy 3 and 18) might represent a large-cell variant of MALT lymphomas. PMID: 16636337

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Involvement in disease Mental retardation with language impairment and autistic features (MRLIAF)
Subcellular Location Nucleus
Tissue Specificity Isoform 8 is specifically expressed in embryonic stem cells.
Database Links

HGNC: 3823

OMIM: 605515

KEGG: hsa:27086

STRING: 9606.ENSP00000318902

UniGene: Hs.59368

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