ING4 Antibody, Biotin conjugated

Code CSB-PA891792LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ING4 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Brain my036 protein antibody; Candidate tumor suppressor p33 ING 1 homolog antibody; Candidate tumor suppressor p33 ING1 homolog antibody; D6Wsu147e antibody; D6Xrf92 antibody; ING 1 like protein antibody; ING 4 antibody; ING1 like protein antibody; ING4 antibody; ING4_HUMAN antibody; Inhibitor of growth family member 4 antibody; Inhibitor of growth family member 4 long isoform antibody; Inhibitor of growth protein 4 antibody; MGC12557 antibody; my036 antibody; p29 ING 4 antibody; p29 ING4 antibody; p29ING4 antibody
Raised in
Species Reactivity
Recombinant Human Inhibitor of growth protein 4 protein (75-249AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11.
Gene References into Functions
  1. Splicing type of ING4 affects the translocation of ING4 proteins into the nucleus. PMID: 30403588
  2. Both CELSR2 and ING4 display increased cytoplasmic staining in breast cancer cells compared to benign epithelium, suggesting a possible role of both genes in the pathogenesis of human mammary neoplasia. PMID: 29489009
  3. These results demonstrated that overexpression of ING4 can induce the apoptosis of melanoma cells and CD3+ T cells through signaling pathways such as the Fas/FasL pathway, and that ING4 gene therapy for melanoma treatment is a novel approach. PMID: 29207034
  4. Inhibitor of growth 4 upregulation plus radiotherapy induced synergistic tumor suppression in SPC-A1 xenografts implanted in athymic nude mice. Thus, the restoration of inhibitor of growth 4 function might provide a potential strategy for non-small cell lung cancer radiosensitization. PMID: 27381846
  5. Results found that ING4 expression was significantly reduced in CRC tissues and associated with increased lymph node metastasis, advanced TNM stage and poor overall survival. Also, ING4 suppressed CRC angiogenesis by inhibition of Sp1 expression and transcriptional activity through destabilization and ubiquitin degradation and down-regulation of Sp1 downstream pro-angiogenic factors MMP-2 and COX-2. PMID: 27806345
  6. Low ING4 expression is associated with malignant phenotype and temozolomide chemoresistance in glioblastomas. PMID: 27471108
  7. ING4 directly binds the Miz1 promoter and is required to induce Miz1 mRNA and protein expression during luminal cell differentiation. PMID: 27527891
  8. The oncogenic role of miR-330 in Hepatocellular Carcinoma Cells is linked to downregulation of ING4. PMID: 28050784
  9. ING4 binds double-stranded DNA through its central region with micromolar affinity. PMID: 27926782
  10. results indicate that the combination of ING4 and PTEN may provide an effective therapeutic strategy for HCC PMID: 27421660
  11. ING4 can facilitate cancer cell sensitivity to chemotherapy and radiotherapy. Although ING4 loss is observed for many types of cancers, increasing evidences show that ING4 can be used for gene therapy. In this review, the recent progress of ING4 regulating tumorigenesis is discussed PMID: 26803518
  12. ING4 inhibits CRC invasion and metastasis probably via a switch from mesenchymal marker N-cadherin to epithelial marker E-cadherin through downregulation of Snail1 epithelial-mesenchymal transition (EMT)-inducing transcription factor (EMT-TF). PMID: 26936485
  13. Data show that Ras protein regulates inhibitor of growth protein 4 (ING4)-thymine-DNA glycosylase (TDG)-Fas protein axis to promote apoptosis resistance in pancreatic cancer. PMID: 26544625
  14. MiR-761 directly targeted ING4 and TIMP2. PMID: 26278569
  15. Data suggest a close connection between aberrant ING4 expression and the carcinogenesis of human bladder cells. PMID: 25790869
  16. This review summarizes the recent published literature that investigates the role of ING4 in regulating tumorigenesis and progression, and explores its potential for cancer treatment. [review] PMID: 25968091
  17. SCF(JFK) as a bona fide E3 ligase for ING4 and unraveled the JFK-ING4-NF-kappaB axis as an important player in the development and progression of breast cancer PMID: 25792601
  18. work suggests that ING4 can suppress osteosarcoma progression through signaling pathways such as mitochondria pathway and NF-kappaB signaling pathway and ING4 gene therapy is a promising approach to treating osteosarcoma. PMID: 25490312
  19. The enhanced antitumor activity generated by Ad.RGD-ING4-PTEN was closely associated with activation of the intrinsic and extrinsic apoptotic pathways and additive inhibition of tumor angiogenesis both in vitro and in vivo. PMID: 25571952
  20. The low expression level of ING4 protein was correlated with high-risk gastrointestinal stromal tumors. PMID: 23504291
  21. loss of ING4, either directly or indirectly through loss of Pten, promotes Myc-driven prostate oncogenesis. PMID: 24762396
  22. ING4 level elevation mediated proliferation and invasion inhibition may be tightly associated with the suppression of NF-kappaB signaling pathway. PMID: 24057236
  23. These findings support a critical role for ING4 expression in normal cells in the non-cell-autonomous regulation of tumor growth. PMID: 23604125
  24. ING4 acts as an E3 ubiquitin ligase to induce ubiquitination of p65 and degradation, which is critical to terminate NFkappaB activation. PMID: 23624912
  25. The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6. PMID: 23967213
  26. these findings suggest that ING4 may be a feasible modulator for the MDR phenotype of gastric carcinoma cells PMID: 23969950
  27. KAI1 overexpression increases ING4 expression in melanoma. PMID: 24130172
  28. ING4 may regulate c-MYC translation by its association with AUF1. PMID: 23603392
  29. Report up-regulation of ING4 expression in sarcoid granulomas. PMID: 23181555
  30. ING4 negatively regulates NF-kappaB in breast cancer PMID: 23056468
  31. Data suggested that miR-650 is correlated with the pathogenesis of hepatocellular carcinoma (HCC) and is involved in the HCC tumorigenesis process by inhibiting the expression of ING4. PMID: 22767438
  32. Loss of ING4 expression is associated with lymphatic metastasis in colon cancer. PMID: 23055189
  33. Inhibitor of growth 4 may represent an important biomarker for assessing the severity of breast cancer PMID: 22436625
  34. crystal structure of the ING4 N-terminal domain PMID: 22334692
  35. Data suggest that ING4 may be a promising target for the treatment for ovarian cancer. PMID: 22228137
  36. Mechanism of ING4 mediated inhibition of the proliferation and migration of human glioma cell line U251. PMID: 22078444
  37. In this review, the different properties of ING4 are discussed, and its activities are correlated with different aspects of cell physiology. [Review] PMID: 21971889
  38. Downregulated expression of inhibitor of growth 4 is associated with colorectal cancers. PMID: 21626442
  39. These results sustain the view that ING4 is a tumor suppressor in breast cancer and suggest that ING4 deletion may contribute to the pathogenesis of HER2-positive breast cancer. PMID: 21315418
  40. results suggest that the decreases in nuclear ING4 may play important roles in tumorigenesis, progression and tumor differentiation in head and neck squamous cell carcinoma. PMID: 21310648
  41. EBNA3C negatively regulate p53-mediated functions by interacting with ING4 and ING5. PMID: 21177815
  42. Loss of ING4 is associated with breast carcinoma. PMID: 20707719
  43. Demonstrated decreased ING4 mRNA and expression in 100% (50/50) lung tumour tissues. Furthermore, ING4 expression was lower in grade III than in grades I-II tumours. Reduced ING4 mRNA correlated with lymph node metastasis. PMID: 20716169
  44. Mutations in ING4 is associated with cancer. PMID: 20705953
  45. our data suggest an essential role for ING-4 in human astrocytoma development and progression possibly through regulation of the NF-kappaB-dependent expression of genes involved in tumor invasion PMID: 19775294
  46. A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis. PMID: 20501848
  47. over-expression of miR-650 in gastric cancer may promote proliferation and growth of cancer cells, at least partially through directly targeting ING4. PMID: 20381459
  48. p29ING4 and p28ING5 may be significant modulators of p53 function. PMID: 12750254
  49. In mice, xenografts of human glioblastoma U87MG, which has decreased expression of ING4, grow significantly faster and have higher vascular volume fractions than control tumours PMID: 15029197
  50. ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells PMID: 15251430

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Subcellular Location
Protein Families
ING family
Database Links

HGNC: 19423

OMIM: 608524

KEGG: hsa:51147

STRING: 9606.ENSP00000380024

UniGene: Hs.524210

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