JAG2 Antibody

Code CSB-PA049990
Size US$166
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  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA049990(JAG2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA049990(JAG2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
Alternative Names
JAG2 antibody; Protein jagged-2 antibody; Jagged2 antibody; hJ2 antibody
Raised in
Species Reactivity
Synthetic peptide of Human JAG2
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen affinity purification
It differs from different batches. Please contact us to confirm it.
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Tested Applications
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:10000
IHC 1:50-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development.
Gene References into Functions
  1. In CL+/-P Malay patients, the prevalence of mutations in the Jagged2 gene was 12.5%. Three variants (g.19779C>T, g.19547G>A, and g.19712C>T) were identified in the Jagged2 gene among nonsyndromic CL+/-P and noncleft patients. Only g.19712C>T showed a significant association with nonsyndromic CL+/-P patients (P = .039). PMID: 26151095
  2. these results show that the Notch signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 or Jagged 2 on DCs is not required PMID: 28111308
  3. The authors present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2, together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch binding is likely to be critical in establishing the optimal context for Notch signalling. PMID: 28572448
  4. Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1 PMID: 22691042
  5. Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells PMID: 26412454
  6. Increased expression of JAG2, a target of miR-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in medulloblastoma. PMID: 25576913
  7. Results show that tumor cell migration, invasion, and metastasis are dependent on JAGGED2 independently of NOTCH activation. PMID: 25351917
  8. silencing prevents Notch2-driven osteoclast development and bone destruction in multiple myeloma PMID: 25257302
  9. Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1. PMID: 24907271
  10. This study demonistrated that NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma. PMID: 24708907
  11. Jagged2 expression status was closely correlated with important histopathologic characteristics (grades and stages) and the recurrence and metastasis of bladder urothelial carcinomas. PMID: 24228105
  12. Notch-1 and Jagged-2 are not expressed in spastic colon segments, which may be associated with the pathogenesis of Hirschsprung disease. PMID: 22030773
  13. JAG2-mediated Notch activation confers phenotypic and functional aspects of Langerhans cell histiocytosis to dendritic cells. PMID: 23074278
  14. JAG2 is often expressed by CD138(+) primary cells. Our results indicate that spontaneous clonogenic growth of myeloma cells requires the expression of JAG2. PMID: 22341562
  15. This study is the first illustration of Notch-1 and Jagged-2 expression in human tissues from non-cancerous disease. PMID: 21892607
  16. hypoxia-induced Jagged2 activation in both tumor invasive front and normal bone stroma has a critical role in tumor progression and metastasis PMID: 21499308
  17. The stromal cell-mediated antiapoptotic effect on B- ALL cells is mediated by Notch-3 and -4 or Jagged-1/-2 and DLL-1 in a synergistic manner. PMID: 21602525
  18. hypoxic induction of JAG2 in tumor cells mediates a hypoxia-regulated cross-talk between tumor and endothelial cells. PMID: 21402725
  19. we have investigated their influence on early human hematopoiesis and show that Jagged2 affects hematopoietic lineage decisions very similarly as Delta-like-1 and -4, but very different from Jagged1 PMID: 21372153
  20. Expression of Notch3 and Jagged2 were highly correlated in tongue carcinoma tissues. PMID: 20819128
  21. Notch signaling may participate in controlling cell differentiation and proliferation in normal bone and COF of the jaws. Notch signaling disorder may be a molecular incident in COF occurrence and development. PMID: 20040020
  22. JAG2 is a direct Myc target and Jagged2 and Notch signaling participate in P493-6 lymphomagenesis. PMID: 20133585
  23. expression required for spermatogenesis in humans and rats PMID: 11700865
  24. JAG2 was found to be overexpressed in malignant plasma cells from MM patients; coculture assay demonstrated that JAG2 induced the secretion of IL-6, VEGF, and IGF-1 in stromal cells; JAG2 overexpression may be an early event in the pathogenesis of MM PMID: 15292061
  25. The upregulation of Jagged2 expression on BMEC was observed upon TNF-alpha activation. Similarly,activation of endothelial cells in Tie2-tmTNF-alpha mice was characterized by increased expression of Jagged2. PMID: 18439488
  26. Results indicate JAG2 may be involved in non-syndromic cleft lip with or without cleft palate etiology in different populations. PMID: 19049519
  27. SMRT function restoration induces JAG2 down-regulation as well as multipe myeloma apoptosis. PMID: 19417136

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney.
Database Links

HGNC: 6189

OMIM: 602570

KEGG: hsa:3714

STRING: 9606.ENSP00000328169

UniGene: Hs.433445

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