MAGI2 Antibody

Code CSB-PA213488
Size US$297
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  • Western blot analysis of extracts from HT-29 cells, using MAGI2 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MAGI2 Polyclonal antibody
Uniprot No.
Target Names
MAGI2
Alternative Names
Activin receptor interacting protein 1 antibody; Acvri1 antibody; Acvrinp1 antibody; ACVRIP1 antibody; AIP 1 antibody; Aip-1 antibody; ARIP1 antibody; Atrophin 1 interacting protein 1 antibody; Atrophin 1 interacting protein A antibody; Atrophin-1-interacting protein 1 antibody; Atrophin-1-interacting protein A antibody; KIAA0705 antibody; MAGI-2 antibody; MAGI2 antibody; MAGI2_HUMAN antibody; Membrane associated guanylate kinase 2 antibody; Membrane associated guanylate kinase inverted 2 antibody; Membrane associated guanylate kinase WW and PDZ domain containing 2 antibody; Membrane associated guanylate kinase WW and PDZ domain containing protein 2 antibody; Membrane-associated guanylate kinase antibody; Membrane-associated guanylate kinase inverted 2 antibody; S SCAM antibody; SSCAM antibody; WW and PDZ domain-containing protein 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from internal of Human MAGI2.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
Gene References into Functions
  1. MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. PMID: 29679339
  2. MAGI-2 immunoreactivity is elevated in prostate cancer and high-grade prostatic intraepithelial neoplasia compared with normal tissue, suggesting that MAGI-2 may contribute to prostate carcinogenesis. PMID: 26980016
  3. Immunohistochemistry in kidney sections from these patients revealed that mutations resulted in lack of or diminished podocyte MAGI2 expression. Our data support the finding that mutations in the MAGI2 gene are causal for congenital steroid-resistant nephrotic syndrome PMID: 27932480
  4. MAGI-2 could represent a useful adjunct for diagnosis of prostatic adenocarcinoma PMID: 27543977
  5. The expression of MAGI2 mRNA was significantly down-regulated in PC3, LNCaP and DU-145 PCa cell lines. PMID: 24985972
  6. MAGI2, SERPINE2, and NT5C3B expression levels are associated with airway wall thickening and additionally with bronchial inflammation, emphysema, and lung function, respectively, all features of chronic obstructive pulmonary disease. PMID: 25517131
  7. Data show that the miR-134/487b/655 cluster regulates TGF-beta1-induced epithelial-mesenchymal transition and affected the resistance to gefitinib by directly targeting membrane-associated guanylate kinase, WW, and PDZ domain-containing protein 2 (MAGI2). PMID: 24258346
  8. In Usher syndrome 1G, mutations in SANS eliminate Magi2 binding and thereby deregulate endocytosis, lead to defective ciliary transport modules and ultimately disrupt photoreceptor cell function inducing retinal degeneration. PMID: 24608321
  9. MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. PMID: 23754155
  10. Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. PMID: 22649501
  11. Results presented herein provide further evidence for a role of MAGI2 in bipolar affective disorder and schizophrenia etiology. PMID: 22381734
  12. Interstitial deletions that include the MAGI2 gene on chromosome 7q11.23-q.21.11 are associated with IS cases. PMID: 18565486
  13. there was no association of MAGI2 and PARD3 with IBD. PMID: 21515326
  14. analysis of 7q11.21-q11.23 and infantile spasms without deletion of MAGI2 [case report] PMID: 20101691
  15. Data show that AIP1 is a novel GTPase-activating protein for Arf6, a small GTPase regulating cellular PIP(2) production and formation of the TLR4-TIRAP-MyD88 complex. PMID: 19948740
  16. PTEN plays a critical role in MAGI-2-induced inhibition of cell migration and proliferation in human hepatocarcinoma cells PMID: 17880912
  17. MAGI2 genetic variation is associated with inflammatory bowel disease. PMID: 18720471

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Involvement in disease
Nephrotic syndrome 15 (NPHS15)
Subcellular Location
Cytoplasm. Late endosome. Cell junction, synapse, synaptosome. Cell membrane; Peripheral membrane protein.
Protein Families
MAGUK family
Tissue Specificity
Specifically expressed in brain.
Database Links

HGNC: 18957

OMIM: 606382

KEGG: hsa:9863

STRING: 9606.ENSP00000346151

UniGene: Hs.603842

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