Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MAGI2 Polyclonal antibody

Uniprot No.

Q86UL8

Target Names

MAGI2

Alternative Names

Activin receptor interacting protein 1 antibody; Acvri1 antibody; Acvrinp1 antibody; ACVRIP1 antibody; AIP 1 antibody; Aip-1 antibody; ARIP1 antibody; Atrophin 1 interacting protein 1 antibody; Atrophin 1 interacting protein A antibody; Atrophin-1-interacting protein 1 antibody; Atrophin-1-interacting protein A antibody; KIAA0705 antibody; MAGI-2 antibody; MAGI2 antibody; MAGI2_HUMAN antibody; Membrane associated guanylate kinase 2 antibody; Membrane associated guanylate kinase inverted 2 antibody; Membrane associated guanylate kinase WW and PDZ domain containing 2 antibody; Membrane associated guanylate kinase WW and PDZ domain containing protein 2 antibody; Membrane-associated guanylate kinase antibody; Membrane-associated guanylate kinase inverted 2 antibody; S SCAM antibody; SSCAM antibody; WW and PDZ domain-containing protein 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 protein (1308-1455AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.

Gene References into Functions

MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. PMID: 29679339
MAGI-2 immunoreactivity is elevated in prostate cancer and high-grade prostatic intraepithelial neoplasia compared with normal tissue, suggesting that MAGI-2 may contribute to prostate carcinogenesis. PMID: 26980016
Immunohistochemistry in kidney sections from these patients revealed that mutations resulted in lack of or diminished podocyte MAGI2 expression. Our data support the finding that mutations in the MAGI2 gene are causal for congenital steroid-resistant nephrotic syndrome PMID: 27932480
MAGI-2 could represent a useful adjunct for diagnosis of prostatic adenocarcinoma PMID: 27543977
The expression of MAGI2 mRNA was significantly down-regulated in PC3, LNCaP and DU-145 PCa cell lines. PMID: 24985972
MAGI2, SERPINE2, and NT5C3B expression levels are associated with airway wall thickening and additionally with bronchial inflammation, emphysema, and lung function, respectively, all features of chronic obstructive pulmonary disease. PMID: 25517131
Data show that the miR-134/487b/655 cluster regulates TGF-beta1-induced epithelial-mesenchymal transition and affected the resistance to gefitinib by directly targeting membrane-associated guanylate kinase, WW, and PDZ domain-containing protein 2 (MAGI2). PMID: 24258346
In Usher syndrome 1G, mutations in SANS eliminate Magi2 binding and thereby deregulate endocytosis, lead to defective ciliary transport modules and ultimately disrupt photoreceptor cell function inducing retinal degeneration. PMID: 24608321
MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. PMID: 23754155
Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. PMID: 22649501
Results presented herein provide further evidence for a role of MAGI2 in bipolar affective disorder and schizophrenia etiology. PMID: 22381734
Interstitial deletions that include the MAGI2 gene on chromosome 7q11.23-q.21.11 are associated with IS cases. PMID: 18565486
there was no association of MAGI2 and PARD3 with IBD. PMID: 21515326
analysis of 7q11.21-q11.23 and infantile spasms without deletion of MAGI2 [case report] PMID: 20101691
Data show that AIP1 is a novel GTPase-activating protein for Arf6, a small GTPase regulating cellular PIP(2) production and formation of the TLR4-TIRAP-MyD88 complex. PMID: 19948740
PTEN plays a critical role in MAGI-2-induced inhibition of cell migration and proliferation in human hepatocarcinoma cells PMID: 17880912
MAGI2 genetic variation is associated with inflammatory bowel disease. PMID: 18720471