RASGRF1 Antibody

Code CSB-PA006353
Size US$100
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Product Details

Uniprot No.
Target Names
Alternative Names
CDC25 antibody; CDC25L antibody; GNRP antibody; GRF1 antibody; GRF55 antibody; Guanine nucleotide exchange factor antibody; Guanine nucleotide releasing factor 55 kD antibody; Guanine nucleotide releasing protein antibody; guanine nucleotide-releasing factor 1 antibody; Guanine nucleotide-releasing protein antibody; H GRF55 antibody; HGRF55 antibody; PP13187 antibody; Ras protein specific guanine nucleotide releasing factor 1 antibody; Ras specific guanine nucleotide releasing factor antibody; Ras specific guanine nucleotide releasing factor CDC25 homolog antibody; Ras specific nucleotide exchange factor CDC25 antibody; Ras-GRF1 antibody; Ras-specific guanine nucleotide-releasing factor 1 antibody; Ras-specific nucleotide exchange factor CDC25 antibody; RASGRF1 antibody; RGRF1_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Mouse,Rat
Immunogen
Synthesized peptide derived from Mouse Ras-GRF1 around the non-phosphorylation site of S916.
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Promotes the exchange of Ras-bound GDP by GTP.
Gene References into Functions
  1. Low RASGRF1 expression due to hypermethylation is associated with Colorectal Cancer. PMID: 29530990
  2. Our studies have shown that the heritability of myopia makes 66.4% in Lithuania. We detected significant associations between the combinations of GJD2 CC and RASGRF1 GT and odds ratio of developing myopia. PMID: 29793445
  3. genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population. PMID: 29044055
  4. Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF. PMID: 27856453
  5. Data show that microRNA miR-137 directly recognized the 3'-UTR (3'-untranslated region) of the RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1) transcript and regulated RASGRF1 expression. PMID: 26440052
  6. Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians. PMID: 26521038
  7. Carriers of the rs8027411 G allele in the RASGRF1 gene may be at a lower risk of high myopia in Chinese and Japanese populations. (Meta-analysis) PMID: 26644762
  8. Rasgrf-1 is a novel GEF protein that has a role in BCR signaling and its overexpression further activates the Ras/Erk/MAPK pathway in CLL specimens. PMID: 24597981
  9. In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2, and ACTC1 with pathological myopia. PMID: 23834555
  10. CARD9 regulates H-Ras activation by linking Ras-GRF1 to H-Ras, which mediates Dectin-1-induced extracellular signal-regulated protein kinase (ERK) activation and proinflammatory responses when stimulated by their ligands. PMID: 25267792
  11. ZIC2 and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia. PMID: 24150758
  12. Decreased expression of Ras-GRF1 could be involved in the pathogenesis of human temporal lobe epilepsy. PMID: 23200899
  13. Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer. PMID: 22961779
  14. RasGRF1 plays an important role in alveolar rhabdomyosarcoma pathogenesis PMID: 22752028
  15. Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation. PMID: 21685891
  16. Single Nucleotide Polymorphisms in RASGRF1 is associated with refractive errors and myopia. PMID: 20835236
  17. Farnesylated or geranylgeranylated TC21 can be activated by RasGRF1 due to its pleckstrin homology 1 domain, by a mechanism independent of localization & of its ability to associate to membranes. PMID: 19692568
  18. RasGRF family exchange factors, both endogenous and ectopically expressed, are present in the endoplasmic reticulum but not in the Golgi complex PMID: 14749369
  19. Taken together our results demonstrate that U2AF35a is essential for HeLa cell division and suggest a novel role for both U2AF35 protein isoforms as regulators of alternative splicing of a specific subset of genes. PMID: 16855028
  20. Vitamin K3 inhibitor H32 differentially inhibited growth of normal and liver tumor cells by preferentially inhibiting the actions of Cdc25 phosphatases PMID: 16969075
  21. Rasgrf1 transgenic repeats serve at least two functions: first, to establish Rasgrf1 DNA methylation in the male germ line, and second, to resist global demethylation in the preimplantation embryo. PMID: 17030618
  22. zoledronate induces DNA damage and S phase arrest, accompanied by activation of the ATM/Chk1/cdc25 pathway in a human osteosarcoma cell line PMID: 17611684
  23. Enhanced expression and post-translational modification of RasGRF1 contributes to MMP-3 production in RA PMID: 19678938

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Database Links

HGNC: 9875

OMIM: 606600

KEGG: hsa:5923

STRING: 9606.ENSP00000405963

UniGene: Hs.459035

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