SHOC2 Antibody, FITC conjugated

Code CSB-PA891468LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SHOC2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
KIAA0862 antibody; Leucine-rich repeat protein SHOC-2 antibody; Protein soc-2 homolog antibody; Protein Sur-8 homolog antibody; Ras-binding protein Sur-8 antibody; SHOC2 antibody; SHOC2_HUMAN antibody
Raised in
Species Reactivity
Recombinant Human Leucine-rich repeat protein SHOC-2 protein (3-89AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Gene References into Functions
  1. Overexpression or knockdown of Sur8 increases or decreases, respectively, the proliferation or transformation of colorectal cancer (CRC) cell lines. Sur8 knockdown attenuates the migration and invasion of HCT116 CRC cells. PMID: 27469030
  2. Results provide evidence that SHOC2 trapping at different subcellular sites has a diverse impact on ERK signaling strength and dynamics, suggesting a dual counteracting modulatory role of SHOC2 in the control of ERK signaling exerted at different intracellular compartments. PMID: 27466182
  3. results demonstrate that PSMC5 is a new and important player involved in regulating ERK1/2 signal transmission through the remodeling of Shoc2 scaffold complex in a spatially-defined manner. PMID: 26519477
  4. Noonan-like syndrome has been related to the invariant c.4A > G missense change in SHOC2. PMID: 22995099
  5. Two unrelated Taiwanese patients have been described with Noonan-like syndrome with loose anagen hair who also have moyamoya disease and in whom heterozygous germline mutation in SHOC2 was found. PMID: 25858597
  6. ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of Epidermal Growth Factor, a stimulus that induces proliferation rather than differentiation in these cells. PMID: 25514808
  7. Extreme phenotypic variability associated with the invariant SHOC2 c.4A>G (p.Ser2Gly) missense mutation in Noonan-like syndrome with loose anagen hair. PMID: 25331583
  8. A newborn heterozygous for the invariant c.4A>G missense change in SHOC2. PMID: 24458587
  9. Data show that both Shoc2 and HUWE1 are necessary to control the levels and ubiquitination of the Shoc2 signaling partner, RAF-1. PMID: 25022756
  10. Both MRAS and SHOC2 play a key role in polarized migration. PMID: 24211266
  11. SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor. PMID: 23076151
  12. targeting of Shoc2 to late endosomes may facilitate EGFR-induced ERK activation under physiological conditions of cell stimulation by EGF, and therefore, may be involved in the spatiotemporal regulation of signaling through the RAS-RAF module PMID: 22606262
  13. The p.Ser2Gly mutation demonstrated introduction of an N-myristoylation site, resulting in aberrant membrane targeting of SHOC2 and impaired translocation to the nucleus upon growth factor stimulation. PMID: 21548061
  14. 92 patients with Noonan syndrome and related disorders to characterize mutations in the SHOC2 gene were analysed. PMID: 20882035
  15. Results indicate that the Shoc2 scaffold protein modulates Ras-dependent Raf1 activation in a Ca(2+)- and calmodulin-dependent manner. PMID: 20071468
  16. Data suggest that Shoc2 regulates the spatio-temporal patterns of the Ras-ERK signaling pathway primarily by accelerating the Ras-Raf interaction. PMID: 20051520
  17. no evidence of leukemogenic SHOC2 involvement in juvenile myelomonocytic leukemia PMID: 20110435
  18. Erbin has a regulatory role in the Ras-Raf-MEK pathway and may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction PMID: 16301319
  19. Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair. PMID: 19684605

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Involvement in disease
Noonan syndrome-like disorder with loose anagen hair 1 (NSLH1)
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
SHOC2 family
Database Links

HGNC: 15454

OMIM: 602775

KEGG: hsa:8036

STRING: 9606.ENSP00000358464

UniGene: Hs.104315

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