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The SLC30A10 antibody is a premium polyclonal antibody used to detect the SLC30A10 protein of human and mouse origin. The recombinant human zinc transporter 10 protein (58-278AA) is used as the immunogen to immunize the rabbit to obtain the SLC30A10 antibody. This unconjugated SLC30A10 antibody exists as an IgG isoform. It is purified using protein G and reaches up to 95% in purity. It has been validated for use in four applications, including ELISA, WB, IHC, and IF. Its target protein SLC30A10 protects cells from manganese ion toxicosis by clearing out manganese when sensing the increased manganese levels. In the liver cells, the SLC30A10 protein removes the manganese by transporting it out of the cells into bile.
|Full Product Name||Rabbit anti-Homo sapiens (Human) SLC30A10 Polyclonal antibody|
SLC30A10; ZNT10; ZNT8; Zinc transporter 10; ZnT-10; Manganese transporter SLC30A10; Solute carrier family 30 member 10
|Species Reactivity||Human, Mouse|
|Immunogen||Recombinant Human Zinc transporter 10 protein (58-278AA)|
|Immunogen Species||Homo sapiens (Human)|
The SLC30A10 Antibody (Product code: CSB-PA747695LA01HU) is Non-conjugated. For SLC30A10 Antibody with conjugates, please check the following table.
|Purification Method||>95%, Protein G purified|
|Concentration||It differs from different batches. Please contact us to confirm it.|
|Buffer||Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
|Tested Applications||ELISA, WB, IHC, IF|
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
|Troubleshooting and FAQs||Antibody FAQs|
|Storage||Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.|
|Lead Time||Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.|
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Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death. Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells.
|Gene References into Functions||
|Involvement in disease||Hypermanganesemia with dystonia 1 (HMNDYT1)|
|Subcellular Location||Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network. Recycling endosome. Early endosome.|
|Protein Families||Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily|
|Tissue Specificity||Specifically expressed in fetal liver and fetal brain. Expressed in adult tissues with relative levels small intestine > liver > testes > brain > ovary > colon > cervix > prostate > placenta.|