SLC30A10 Antibody

Code CSB-PA747695LA01HU
Size US$299
  • Western Blot
    Positive WB detected in: Mouse brain tissue
    All lanes: SLC30A10 antibody at 3μg/ml
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 53, 27, 25 kDa
    Observed band size: 53 kDa

  • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA747695LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA747695LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details


The SLC30A10 antibody is a premium polyclonal antibody used to detect the SLC30A10 protein of human and mouse origin. The recombinant human zinc transporter 10 protein (58-278AA) is used as the immunogen to immunize the rabbit to obtain the SLC30A10 antibody. This unconjugated SLC30A10 antibody exists as an IgG isoform. It is purified using protein G and reaches up to 95% in purity. It has been validated for use in four applications, including ELISA, WB, IHC, and IF. Its target protein SLC30A10 protects cells from manganese ion toxicosis by clearing out manganese when sensing the increased manganese levels. In the liver cells, the SLC30A10 protein removes the manganese by transporting it out of the cells into bile.

Full Product Name Rabbit anti-Homo sapiens (Human) SLC30A10 Polyclonal antibody
Uniprot No. Q6XR72
Target Names SLC30A10
Alternative Names
SLC30A10; ZNT10; ZNT8; Zinc transporter 10; ZnT-10; Manganese transporter SLC30A10; Solute carrier family 30 member 10
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Zinc transporter 10 protein (58-278AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The SLC30A10 Antibody (Product code: CSB-PA747695LA01HU) is Non-conjugated. For SLC30A10 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA747695LB01HU SLC30A10 Antibody, HRP conjugated ELISA
FITC CSB-PA747695LC01HU SLC30A10 Antibody, FITC conjugated
Biotin CSB-PA747695LD01HU SLC30A10 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:100-1:500
IF 1:50-1:500
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death. Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells.
Gene References into Functions
  1. Structural homology analysis provide evidence that L349P mutation severe structural changes of ZnT-10 in its CTD domain resulting in abnormal reduced function. PMID: 27550551
  2. SLC30A10 has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK-ATF4 pathway. PMID: 28688763
  3. xpressing either wild-type or mutant forms of SLC30A10 was sufficient to inhibit the effect of ATP2C1 in response to Mn challenge in both zebrafish embryos and HeLa cells. These findings suggest that either activating ATP2C1 or restoring the Mn-induced trafficking of ATP2C1 can reduce Mn accumulation, providing a possible target for treating HMDPC. PMID: 28692648
  4. results indicate that residues in the transmembrane and C-terminal domains together confer optimal manganese transport capability to SLC30A10 and suggest that the mechanism of ion coordination in the transmembrane domain of SLC30A10 may be substantially different from that in YiiP/other SLC30 proteins. PMID: 27307044
  5. allele was also associated with increased sway velocity (15%, P = .033; adjusted for age and sex) and reduced SLC30A10 expression PMID: 26628504
  6. We describe early disease manifestations (including videos) in 5 previously unreported Indian children, carrying novel homozygous SLC30A10 mutation PMID: 25778823
  7. SLC30A10 is a cell surface-localized manganese efflux transporter that reduces manganese levels and protects against manganese toxicity. PMID: 25319704
  8. These results suggest that both the up-regulation of ZIP14 and the down-regulation of ZnT10 by IL-6 might have enhanced the accumulation of manganese in SH-SY5Y cells. PMID: 24576911
  9. a case of inherited manganism caused by SLC30A10 mutation is presented PMID: 23369405
  10. ZnT10 is significantly decreased in the frontal cortex in Alzheimer's disease. PMID: 23741496
  11. This review will address Mn transport proteins, the newly discovered SLC30A10 mutations and their implications to Parkinsonism and Mn regulation. PMID: 23357421
  12. The study demonstrates down-regulation by Zn of ZnT10 mRNA levels in cultured intestinal and neuroblastoma cell lines and demonstrate reduced transcription from the ZnT10 promoter at an elevated extracellular Zn concentration. PMID: 22706290
  13. SLC30A10 mutations cause a treatable recessive disease with pleomorphic phenotype, and provide compelling evidence that SLC30A10 plays a pivotal role in manganese transport. PMID: 22341971
  14. This work has confirmed that SLC30A10 functions as a Mn transporter in humans that, when defective, causes Mn accumulation in liver and brain. PMID: 22341972
  15. identified the full-length sequences of SLC30A10, extending the SLC30 family to ten members; used an expressed sequence tag (EST) data mining strategy to determine the pattern of ZnT genes expression in tissues PMID: 15154973

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Involvement in disease Hypermanganesemia with dystonia 1 (HMNDYT1)
Subcellular Location Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network. Recycling endosome. Early endosome.
Protein Families Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
Tissue Specificity Specifically expressed in fetal liver and fetal brain. Expressed in adult tissues with relative levels small intestine > liver > testes > brain > ovary > colon > cervix > prostate > placenta.
Database Links

HGNC: 25355

OMIM: 611146

KEGG: hsa:55532

STRING: 9606.ENSP00000355893

UniGene: Hs.284450

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