SLC5A6 Antibody

1. This study shows for the first time that LPS inhibits colonic biotin uptake via decreasing membrane expression of its transporter and that these effects likely involve a CK2-mediated pathway. PMID: 28052864
2. S. typhimurium infection inhibits intestinal biotin uptake by SLC5A6, and that the inhibition is mediated via the action of proinflammatory cytokines. PMID: 25999427
3. SMVT-mediated transport is highly specific for R-(+)-alpha-lipoic acid. PMID: 25971966
4. SLC5A6 is responsible for the supplies of biotin and pantothenic acid into the brain across the blood brain barrier. PMID: 25809983
5. these studies demonstrated for the first time the functional and molecular expression of sodium dependent multivitamin transporter (SMVT) in human derived breast cancer (T47D) cells PMID: 23142496
6. This study shows for the first time the functional and molecular presence of SMVT in immortalized human corneal epithelial (HCEC) and retinal pigment epithelial (D407) cells PMID: 22927035
7. PCR analysis had confirmed the existence of FR-alpha, SMVT, and B ((0, +)) in Y-79 and ARPE-19 cells. PMID: 22304562
8. This study for the first time confirms the molecular expression of SMVT and demonstrates that SMVT, responsible for biotin uptake, is functionally active in PC-3 prostate cancer cells PMID: 22732670
9. Cys(294) is essential for the function of the human sodium-dependent multivitamin transporter. PMID: 22015582
10. Human SMVT protein is glycosylated, and that glycosylation is important for its function. The study also shows a role for the putative PKC-phosphorylation site Thr(286) of hSMVT in the PKC-mediated regulation of biotin uptake. PMID: 21570947
11. PDZD11 is an interacting partner with hSMVT in intestinal epithelial cells and that this interaction affects hSMVT function and cell biology. PMID: 21183659
12. These results show important role for His(1)(1) and His(2) residues in hSMVT function, which is most probably mediated via an effect on level of hSMVT expression at the cell membrane. PMID: 20962270
13. hSMVT may play an important role in the homeostasis of I(-) in the body PMID: 20980265
14. in intestinal and liver epithelial cells, SMVT is the major (if not the only) biotin uptake system that operates. PMID: 12646417
15. biotin uptake by human renal epithelial cells occurs via the hSMVT system and that the process is regulated by intracellular PKC- and Ca(2+)/calmodulin-mediated pathways. PMID: 15561972
16. A sodium-dependent multivitamin transporter, SMVT, responsible for biotin uptake and transport, was identified and functionally characterized in MDCK-MDR1 cells. PMID: 16749865
17. Human intestinal biotin uptake is adaptively regulated but is not mediated via changes in hSMVT RNA stability. PMID: 16959947
18. KLF-4 and AP-2 is regulating the activity of the hSMVT promoter in the intestine and provide direct in vivo confirmation of hSMVT promoter activity. PMID: 17135299
19. findings from this study are consistent with the theory that HCS senses biotin, and that biotin regulates its own cellular uptake by participating in HCS-dependent chromatin remodeling events at the SMVT promoter 1 locus in Jurkat cells. PMID: 17904341
20. Conclude that the COOH tail of hSMVT contains several determinants important for polarized targeting and biotin transport in epithelial cells. PMID: 19211916

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HGNC: 11041

OMIM: 604024

KEGG: hsa:8884

STRING: 9606.ENSP00000310208

UniGene: Hs.435735