SLC5A6 Antibody

Code CSB-PA156532
Size US$297
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  • Western blot analysis of extracts from HepG2 cells and HUVEC cells, using SLC5A6 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC5A6 Polyclonal antibody
Uniprot No.
Target Names
SLC5A6
Alternative Names
E430023I20 antibody; MGC109689 antibody; Na(+)-dependent multivitamin transporter antibody; SC5A6_HUMAN antibody; Slc5a6 antibody; SMVT antibody; Sodium-dependent multivitamin transporter antibody; Solute carrier family 5 (sodium dependent vitamin transporter) member antibody; Solute carrier family 5 member 6 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human SLC5A6.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sodium-dependent multivitamin transporter that transports pantothenate, biotin and lipoate. Required for biotin and pantothenate uptake in the instestine. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin. May play a role in the transport of biotin and pantothenate into the brain across the blood-brain barrier. May also be involved in the sodium-dependent transport of iodide ions.
Gene References into Functions
  1. This study shows for the first time that LPS inhibits colonic biotin uptake via decreasing membrane expression of its transporter and that these effects likely involve a CK2-mediated pathway. PMID: 28052864
  2. S. typhimurium infection inhibits intestinal biotin uptake by SLC5A6, and that the inhibition is mediated via the action of proinflammatory cytokines. PMID: 25999427
  3. SMVT-mediated transport is highly specific for R-(+)-alpha-lipoic acid. PMID: 25971966
  4. SLC5A6 is responsible for the supplies of biotin and pantothenic acid into the brain across the blood brain barrier. PMID: 25809983
  5. these studies demonstrated for the first time the functional and molecular expression of sodium dependent multivitamin transporter (SMVT) in human derived breast cancer (T47D) cells PMID: 23142496
  6. This study shows for the first time the functional and molecular presence of SMVT in immortalized human corneal epithelial (HCEC) and retinal pigment epithelial (D407) cells PMID: 22927035
  7. PCR analysis had confirmed the existence of FR-alpha, SMVT, and B ((0, +)) in Y-79 and ARPE-19 cells. PMID: 22304562
  8. This study for the first time confirms the molecular expression of SMVT and demonstrates that SMVT, responsible for biotin uptake, is functionally active in PC-3 prostate cancer cells PMID: 22732670
  9. Cys(294) is essential for the function of the human sodium-dependent multivitamin transporter. PMID: 22015582
  10. Human SMVT protein is glycosylated, and that glycosylation is important for its function. The study also shows a role for the putative PKC-phosphorylation site Thr(286) of hSMVT in the PKC-mediated regulation of biotin uptake. PMID: 21570947
  11. PDZD11 is an interacting partner with hSMVT in intestinal epithelial cells and that this interaction affects hSMVT function and cell biology. PMID: 21183659
  12. These results show important role for His(1)(1) and His(2) residues in hSMVT function, which is most probably mediated via an effect on level of hSMVT expression at the cell membrane. PMID: 20962270
  13. hSMVT may play an important role in the homeostasis of I(-) in the body PMID: 20980265
  14. in intestinal and liver epithelial cells, SMVT is the major (if not the only) biotin uptake system that operates. PMID: 12646417
  15. biotin uptake by human renal epithelial cells occurs via the hSMVT system and that the process is regulated by intracellular PKC- and Ca(2+)/calmodulin-mediated pathways. PMID: 15561972
  16. A sodium-dependent multivitamin transporter, SMVT, responsible for biotin uptake and transport, was identified and functionally characterized in MDCK-MDR1 cells. PMID: 16749865
  17. Human intestinal biotin uptake is adaptively regulated but is not mediated via changes in hSMVT RNA stability. PMID: 16959947
  18. KLF-4 and AP-2 is regulating the activity of the hSMVT promoter in the intestine and provide direct in vivo confirmation of hSMVT promoter activity. PMID: 17135299
  19. findings from this study are consistent with the theory that HCS senses biotin, and that biotin regulates its own cellular uptake by participating in HCS-dependent chromatin remodeling events at the SMVT promoter 1 locus in Jurkat cells. PMID: 17904341
  20. Conclude that the COOH tail of hSMVT contains several determinants important for polarized targeting and biotin transport in epithelial cells. PMID: 19211916

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Subcellular Location
Cell membrane; Multi-pass membrane protein.; Cell membrane; Multi-pass membrane protein.
Protein Families
Sodium:solute symporter (SSF) (TC 2.A.21) family
Tissue Specificity
Expressed in microvessels of the brain (at protein level). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
Database Links

HGNC: 11041

OMIM: 604024

KEGG: hsa:8884

STRING: 9606.ENSP00000310208

UniGene: Hs.435735

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