USP18 Antibody, Biotin conjugated

Code CSB-PA891559LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) USP18 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
43 kDa ISG15 specific protease antibody; 43 kDa ISG15-specific protease antibody; EC 3.1.2. antibody; hUBP43 antibody; Interferon Stimulated Gene 43 kD antibody; ISG15 Specific Processing Protease antibody; ISG15-specific-processing protease antibody; ISG43 antibody; Ubiquitin Specific Peptidase 18 antibody; Ubiquitin Specific Protease 18 43 kD antibody; Ubiquitin Specific Protease 18 antibody; Ubl carboxyl terminal hydrolase 18 antibody; Ubl carboxyl-terminal hydrolase 18 antibody; Ubl thioesterase 18 antibody; Ubl thiolesterase 18 antibody; Ubp15 antibody; UBP18_HUMAN antibody; USP18 antibody
Raised in
Species Reactivity
Recombinant Human Ubl carboxyl-terminal hydrolase 18 protein (18-118AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Involved in the negative regulation of the inflammatory response triggered by type I interferon. Upon recruitment by STAT2 to the type I IFN receptor subunit IFNAR2 interferes with the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and acts as a negative regulator of the type I IFN signaling pathway. Also regulates protein ISGylation. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.; Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins.
Gene References into Functions
  1. These results demonstrate that virus-induced IFN-lambda4 potently blocks IFN-alpha signalling by inducing high protein levels of ISG15 and USP18. Moreover, the data clearly demonstrate that DAA therapy restores IFN-alpha responsiveness in HCV-infected cells. PMID: 28630501
  2. The role of USP18 in breast cancer provides a novel insight into the clinical application of the USP18/AKT/Skp2 pathway. PMID: 29749454
  3. High expression levels of USP18 in the muscles of dermatomyositis patients. PMID: 27605457
  4. study preliminary elucidated the role of USP18 in hepatitis B virus replication and explored the potential key genes in USP18-mediated signaling pathway PMID: 28369997
  5. this study identified PTEN as a previously unrecognized substrate of the ISGylation post-translational modification pathway. The deconjugase USP18 serves as a novel regulator of PTEN stability. This indicates inhibition of ISGylation is therapeutically relevant in cancers. PMID: 27980214
  6. associates with and deubiquitinates TAK1 to protect against hepatic steatosis, insulin resistance, and the inflammatory response PMID: 28718215
  7. that Ubiquitin-specific peptidase 18 directly bind to BCL2L1 and positively regulated its expression in hepatocellular carcinoma cells PMID: 28709980
  8. These findings add USP18 deficiency to the list of genetic disorders collectively termed type I interferonopathies PMID: 27325888
  9. We show that IRF-7 siRNA knockdown enhanced LPS-induced IL-10 production in human monocyte-derived macrophages, and USP-18 overexpression attenuated LPS-induced production of IL-10 in RAW264.7 cells. Quantitative PCR confirmed upregulation of USP18, USP41, IL10, and IRF7. An independent cohort confirmed LPS induction of USP41 and IL10 genes PMID: 27434537
  10. results indicated that USP18 modulates the anti-HBV activity of IFN-F via activation of the JAK/STAT signaling pathway in Hepg2.2.15 cells. PMID: 27227879
  11. USP18's ISG15 specificity is mediated by a small interaction interface. PMID: 28165509
  12. STAT2 recruits USP18 to the type I IFN receptor subunit IFNAR2 via its constitutive membrane-distal STAT2-binding site. PMID: 28165510
  13. findings show that multiple inflammatory stimuli can modulate interferon stimulated gene expression and thus inhibit hepatocyte interferon signaling via USP18 induction PMID: 27009955
  14. USP18 negatively regulates NF-kappaB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms. PMID: 26240016
  15. Data suggest that USP18 (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 and PEPT2. PMID: 26046984
  16. Dimerization of IFNAR1 and IFNAR2 and the limiting role of IFNAR1 binding affinity in complex assembly is modulated by USP18. PMID: 26008745
  17. increased expression in the HIV+/HCV+ female patients group compared with HIV-/HCV+ and HIV+/HCV- groups PMID: 24955730
  18. USP18 expression levels induced by IFNbeta did not differ amongst multiple sclerosis patients carrying different rs2542109 genotypes PMID: 23700969
  19. USP18 inhibition induces inflammation by increasing the STAT signaling and exacerbates IFN-induced beta cell apoptosis. PMID: 23152055
  20. Usp18 upregulation was associated with Wilms Tumor. PMID: 23291318
  21. A direct relationship was found between UBP43 and cyclin D1 (but not cyclin E) expression. PMID: 22752428
  22. USP18 establishes the transcriptional and anti-proliferative interferon alpha/beta differential PMID: 22731491
  23. USP18 is up-regulated in liver samples of patients with chronic hepatitis C that did not respond to therapy, but not in patients with acute hepatitis C. PMID: 22677194
  24. although UBP43 depletion can cause hypersensitivity to interferon-alpha/beta-mediated apoptosis in a broad range of cell types, the downstream pathway may vary depending on the cell type. PMID: 22683641
  25. the existence of an N-terminal truncated isoform of USP18, whose expression is controlled on translational level by two independent mechanisms providing translational flexibility PMID: 22170061
  26. Inhibition of R. conorii-induced ISG15 by RNA interference results in significant increase in the extent of rickettsial replication, whereas UBP43 knockdown yields a reciprocal inhibitory effect. PMID: 22100648
  27. a model in which Usp18 inhibition promotes up-regulation of miR-7, which in turn inhibits EGFR expression and the tumorigenic activity of cancer cells. PMID: 21592959
  28. Findings define the ubiquitin protease UBP43 as a novel candidate drug target for APL treatment. PMID: 20935222
  29. Findings suggest that USP18 may significantly limit operation of the extrinsic apoptotic pathway triggered by type I IFN and drugs. PMID: 20068173
  30. UBP43 protein levels are regulated by proteolysis via the SCFSkp2 ubiquitin ligase PMID: 15342634
  31. Ubp43 deficiency increases the resistance to oncogenic transformation by BCR-ABL PMID: 17374743
  32. Epstein-Barr virus independent dysregulation of UBP43 expression alters interferon-stimulated gene expression in Burkitt lymphoma PMID: 19551150

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Involvement in disease
Pseudo-TORCH syndrome 2 (PTORCH2)
Subcellular Location
[Isoform 1]: Cytoplasm.; [Isoform 2]: Nucleus. Cytoplasm.
Protein Families
Peptidase C19 family
Database Links

HGNC: 12616

OMIM: 607057

KEGG: hsa:11274

STRING: 9606.ENSP00000215794

UniGene: Hs.38260

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