Recombinant Human ATP-binding cassette sub-family A member 1(ABCA1) ,partial

Code CSB-YP001033HU
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Source Yeast
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Code CSB-EP001033HU
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Source E.coli
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Code CSB-EP001033HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001033HU
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Source Baculovirus
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Code CSB-MP001033HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names ABCA1
Uniprot No. O95477
Alternative Names ABC 1; ABC Transporter 1; ABC-1; ABC1; ABCA 1; ABCA1; ABCA1_HUMAN; ATP binding Cassette 1; ATP binding cassette sub family A ABC1 member 1; ATP binding cassette sub family A member 1; ATP binding Cassette Transporter 1; ATP-binding cassette 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; CERP; Cholesterol efflux regulatory protein; FLJ14958; HDLDT1; Membrane bound; MGC164864; MGC165011; TD; TGD
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
Gene References into Functions
  1. ABCA1 regulates phosphoantigen release and Vgamma9Vdelta2 T cell activation by dendritic cells PMID: 28580927
  2. HSP70 suppresses the expression of ABCA1 and ABCG1 through preventing Elk-1 from binding to the promoter of ABCA1 and ABCG1 in human THP-1-derived macrophages. PMID: 29678642
  3. We conclude that at term the apoA-1/ABCA1 pathway is rather involved in cholesterol transport to the mother than in transfer to the fully developed fetus. PMID: 30096856
  4. the ABCA1 rs1800977 polymorphism may contribute to the development of T2DM. PMID: 29439145
  5. Downregulation of ABCA1 in macrophages promoted atherosclerotic lesions. PMID: 30393020
  6. that ABCA1 was a direct target of miR-361-5p and was down-regulated in hypoxia-induced migration and apoptosis of pulmonary artery smooth muscle cells PMID: 29339076
  7. data suggest that there are significant interactive effects between ABCA1 I883M and ALT levels on HDL-C and LDL-C levels. PMID: 28891316
  8. vaspin decreased miR-33a levels, which in turn increased ABCA1 expression and cholesteorl efflux. PMID: 29653102
  9. ABCA1 rs2230806 had a significant association with prevalence of Type 2 Diabetes. PMID: 29621814
  10. Confirmed by mRNA and protein expression, the amino acid transporters SLC7A7 and SLC38A5 showed marked differences between controls and intrauterine growth restriction/pre-eclampsia and were regulated by both diseases. In contrast, ABCA1 may play an exclusive role in the development of pre-eclempsia. PMID: 29499643
  11. Single Nucleotide Polymorphism in ABCA1 gene is associated with dyslipidemia. PMID: 29758034
  12. rs9282541 not associated with pediatric-onset type 2 diabetes PMID: 28101933
  13. Increased expression of hepatic ABCA1 transporter is associated with hypercholesterolemia in a cholestatic rat model and primary biliary cholangitis patients. PMID: 28660384
  14. Review/Meta-analysis: significant association of ABCA1 rs2230806 GG with increased risk of ischemic stroke. PMID: 28865324
  15. Results showed that ABCA1 participates in the alpha-synuclein transport of cholesterol through the plasma membrane of neuronal cells. PMID: 29048372
  16. HECTD1 may be involved in the regulation of ABCA1-mediated cholesterol export from unloaded macrophages to apoA-I. PMID: 29306077
  17. ABCA1 R219K RR+RK genotype frequency in Alzheimer and Parkinson Disease patients was lower than that in normal controls (NC), while ABCA1 R219K KK genotype frequency was significantly higher. ABCA1 R219K R allele was the risk factor inducing abnormal serum levels of ApoA2, LDL, and TG in AD patients, and abnormal levels of serum ABCA1, HDL, IL-1beta, IL-6, and TNF-alpha in PD patients. PMID: 28943632
  18. This study provides evidence that, in HepG2 cells, GLP-1 may affect cholesterol homeostasis by regulating the expression of miR-758 and ABCA1. PMID: 29453982
  19. Hsp27 may up-regulate the expression of ABCA1 and promotes cholesterol efflux through activation of the PI3K/PKCzeta/Sp1 signal pathway in THP-1 macrophage-derived foam cells PMID: 28610841
  20. the present study revealed that overexpression of GLP1R significantly reduces proliferation, migration and cytokine release in ASM cells from COPD patients; this involved a significant increase in ABCA1 expression levels. This provided evidence to suggest that GLP1R may be a potential therapeutic target for the treatment of COPD. PMID: 28560433
  21. Abnormal expression of ABCA1 may be associated with the dysregulation of placental lipid metabolism and the occurrence or development of spontaneous deliveries. PMID: 28630870
  22. apoA-II enhanced ABCA1-mediated cholesterol efflux PMID: 28476857
  23. Cholesterol efflux from THP-1 macrophages is decreased in the presence of plasma obtained from humans and rats with mild hyperbilirubinemia. A direct effect of unconjugated bilirubin on cholesterol efflux was demonstrated and is associated with decreased ABCA1 protein expression. PMID: 28455345
  24. identified HuR as a novel posttranscriptional regulator of ABCA1 expression and cellular cholesterol homeostasis, thereby opening new avenues for increasing cholesterol efflux from atherosclerotic foam macrophages and raising circulat-ing HDL cholesterol levels. PMID: 24729624
  25. Hepatic ABCA1 deficiency results in increased hepatic triglyceride and ANGPTL3 secretion, potentially underlying the elevated plasma triglyceride levels in Tangier disease patients. PMID: 28330813
  26. ABCA1-derived nascent high-density lipoprotein-apolipoprotein AI and lipids metabolically segregate. PMID: 29074589
  27. Hepatic free cholesterol content was significantly increased in NASH as compared to non-NASH subjects, while ABCA1 and ABCG1 protein levels significantly decreased with NASH and fibrosis progression. The relative expression of miR-33a and miR-144 correlated inversely with ABCA1 but not with ABCG1 protein levels. miR-33a/144 and their target gene ABCA1 may contribute to the pathogenesis of NASH in morbidly obese subjects. PMID: 26945479
  28. Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases PMID: 28241820
  29. ABCA1 was mainly located on trophoblast membranes. Decreased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.01). while increased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.05). ABCA1 was uniformly expressed on the cell membrane, cytoplasm, and nucleus of macrophages. PMID: 29066252
  30. AMPK activates LXRalpha and ABCA1 expression in human macrophages PMID: 27343431
  31. Microparticles are lipoprotein-sized structures created by the ABCA1 transporter, and contribute approximately 30% of ABCA1-and apoA-I mediated cholesterol efflux. MPs release from cells consists, in part, of exosomes and depends on the same pathway used for HDL biogenesis. PMID: 28129550
  32. there is an NFATc1/ABCA1-dependent mechanism in which local TNF is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF, TNFR1, or TNFR2 serum levels PMID: 27482889
  33. Reduced platelet count, but no major platelet function abnormalities, are associated with loss-of-function ATP-binding cassette-1 gene mutations. PMID: 28634189
  34. Study report the cryo-EM structure of human ABCA1 with nominal resolutions of 4.1 A for the overall structure and 3.9 A for the massive extracellular domain. The nucleotide-binding domains display a nucleotide-free state, while the two transmembrane domains contact each other through a narrow interface in the intracellular leaflet of the membrane. PMID: 28602350
  35. ABCB1 status is significantly associated with chemo-resistance and poor prognosis in patients with epithelial ovarian cancer PMID: 27812204
  36. ABCA1 mediates ApoA-I and ApoA-I mimetic peptide mobilization of extracellular cholesterol microdomains deposited by macrophages. PMID: 27758769
  37. EEPD1 is a novel LXR-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1. PMID: 28082258
  38. This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences PMID: 28464932
  39. Pim-1L protects hepatic ABCA1 from lysosomal degradation by facilitating the physical interaction between ABCA1 and liver X receptor beta and subsequent stabilization of the ABCA1-Pim-1L complex and thereby regulates the circulating level of high-density lipoprotein. PMID: 27765770
  40. High expression of ABCA1 is associated with high carotid intima-media thickness. PMID: 27841945
  41. Thyrotropin regulated cholesterol content and ABCA1 expression in hepG2 cells. PMID: 27179782
  42. This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to coronary heart disease (CHD) while the CRP +1059G/C polymorphism appears to have no correlation with susceptibility to CHD. PMID: 27560308
  43. ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner. PMID: 27377933
  44. Results suggest that enhanced expression of miR-33a might induce cholesterol accumulation and aggravate inflammation in vessel walls by suppressing the expression of ABCA1 in macrophages. PMID: 27664032
  45. AIBP promotes apoA-1 binding to ABCA1 on the cell membrane of macrophages and prevents ABCA1 protein from CSN2-mediated degradation so as to prevent foam cell formation PMID: 27017521
  46. ABCA1 gene expression positively correlated with obesity indicators. PMID: 27420620
  47. The results of this study indicated that ABCA1 rs2422493 polymorphism was statistically significant associated with increasing Alzheimer's disease risk. PMID: 27215623
  48. These findings suggest that some common variants on the chromosome 9p21 and ABCA1 and their interactions may significantly modify the risk of Coronary Heart Disease and is independent of effects on serum lipid levels. PMID: 27096864
  49. In people with mild cognitive impairement and Alzheimer disease, the capacity of CSF to facilitate ABCA1-mediated cholesterol efflux is impaired. PMID: 26873692
  50. miR-183 degrades ABCA1 mRNA in colon cancer cells. PMID: 26935154

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Involvement in disease High density lipoprotein deficiency 1 (HDLD1); High density lipoprotein deficiency 2 (HDLD2)
Subcellular Location Membrane, Multi-pass membrane protein
Protein Families ABC transporter superfamily, ABCA family
Tissue Specificity Widely expressed, but most abundant in macrophages.
Database Links

HGNC: 29

OMIM: 205400

KEGG: hsa:19

STRING: 9606.ENSP00000363868

UniGene: Hs.659274

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