Recombinant Human Beclin 1-associated autophagy-related key regulator(ATG14)

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Code CSB-EP741052HU
Product Type Recombinant Protein
Size US$1675Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q6ZNE5
Abbreviation ATG14
Relevance Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP741052HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) ATG14.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP741052HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) ATG14.
Storage Buffer Tris-based buffer,50% glycerol
Alias Autophagy-related protein 14-like protein Short name:Atg14L
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MASPSGKGARALEAPGCGPRPLARDLVDSVDDAEGLYVAVERCPLCNTTRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSRLKSKQEEFQKEVLKAMEGKWITDQLRWKIMSCKMRIEQLKQTICKGNEEMEKNSEGLLKTKEKNQKLYSRAQRHQEKKEKIQRHNRKLGDLVEKKTIDLRSHYERLANLRRSHILELTSVIFPIEEVKTGVRDPADVSSESDSAMTSSTVSKLAEARRTTYLSGRWVCDDHNGDTSISITGPWISLPNNGDYSAYYSWVEEKKTTQGPDMEQSNPAYTISAALCYATQLVNILSHILDVNLPKKLCNSEFCGENLSKQKFTRAVKKLNANILYLCFSQHVNLDQLQPLHTLRNLMYLVSPSSEHLGRSGPFEVRADLEESMEFVDPGVAGESDESGDERVSDEETDLGTDWENLPSPRFCDIPSQSVEVSQSQSTQASPPIASSSAGGMISSAAASVTSWFKAYTGHR
Research Area Others
Source E.coli
Gene Names ATG14
Protein Names Recommended name: Beclin 1-associated autophagy-related key regulator Short name= Barkor Alternative name(s): Autophagy-related protein 14-like protein Short name= Atg14L
Expression Region 1-492aa
Tag Info N-terminal 10xHis-tagged and C-terminal Myc-tagged
Mol. Weight 60.3kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1
Subcellular Location Cytoplasm, Endoplasmic reticulum membrane, Peripheral membrane protein, Preautophagosomal structure membrane, Peripheral membrane protein, Cytoplasmic vesicle, autophagosome membrane, Peripheral membrane protein
Protein Families ATG14 family
Database Links

HGNC: 19962

OMIM: 613515

KEGG: hsa:22863

STRING: 9606.ENSP00000247178

UniGene: Hs.414809

Pathway Autophagy

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