Recombinant Human Carabin (TBC1D10C)

Code CSB-YP810269HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP810269HU
MSDS
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Source E.coli
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Code CSB-EP810269HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP810269HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP810269HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
TBC1D10C
Uniprot No.
Alternative Names
1810062O14Rik; AI428527; Carabin; FLJ00332; MGC46488; RGD1311490; TB10C_HUMAN; TBC1 domain family member 10C; TBC1D10C
Species
Homo sapiens (Human)
Expression Region
1-446
Target Protein Sequence
MAQALGEDLV QPPELQDDSS SLGSDSELSG PGPYRQADRY GFIGGSSAEP GPGHPPADLI RQREMKWVEM TSHWEKTMSR RYKKVKMQCR KGIPSALRAR CWPLLCGAHV CQKNSPGTYQ ELAEAPGDPQ WMETIGRDLH RQFPLHEMFV SPQGHGQQGL LQVLKAYTLY RPEQGYCQAQ GPVAAVLLMH LPPEEAFWCL VQICEVYLPG YYGPHMEAVR LDAEVFMALL RRLLPHVHKH LQQVGVGPLL YLPEWFLCLF ARSLPFPTVL RVWDAFLSEG ARVLFRVGLT LVRLALGTAE QRGACPGLLE TLGALRAIPP AQLQEEAFMS QVHSVVLSER DLQREIKAQL AQLPDSAPGP PPRPQVRLAG AQAIFEAQQL AGVRRGAKPE VPRIVVQPPE EPRPPRRKPQ TRGKTFHGLL TRARGPPIEG PPRPQRGSTS FLDTRF
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.
Gene References into Functions
  1. Carabin as a new negative regulator of B-cell function, whose deficiency in B cells speeds up early B-cell responses PMID: 23109291
  2. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
  3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
  4. Carabin is a negative feedback inhibitor of the calcineurin signalling pathway that also mediates crosstalk between calcineurin and Ras PMID: 17230191
  5. Carabin inhibits calcineurin and Ras and was identified by a yeast-two-hybrid screen with calcineurin PMID: 17230191

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Tissue Specificity
Most abundant in spleen and peripheral blood leukocytes.
Database Links

HGNC: 24702

OMIM: 610831

KEGG: hsa:374403

STRING: 9606.ENSP00000310193

UniGene: Hs.534648

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