Recombinant Human Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)

1. This study provides evidence for an essential role of DYRK1A as balanced regulator of S-phase entry in Hepatic progenitor cells (HPCs). An exact gene dosage is crucial, as both DYRK1A deficiency and overexpression affect HPC cell cycle progression. PMID: 29179659
2. LncRNA OIP5-AS1 suppressed cell viability, promoted radio-induced apoptosis, and enhanced the radiosensitivity of CRC cells by regulating DYRK1A expression through miR-369-3p. PMID: 29773344
3. The authors show here that chemical inhibition or genetic knockdown of DYRK1A interferes with neural specification of human pluripotent stem cells, a process equating to the earliest stage of human brain development. Specifically, DYRK1A inhibition insulates the self-renewing subpopulation of human pluripotent stem cells from powerful signals that drive neural induction. PMID: 28884684
4. These results indicate a functional deficiency of DYRK1A as an underlying disease mechanism for autism. PMID: 29021890
5. Inhibition of DYRK1A resulted in an increased apoptosis and decrease in invasion and colony formation ability of HNSCC cell lines. PMID: 27796319
6. Immunoprecipitation and pulldown experiments identified DCAF7 as an adaptor for the association of the adenovirus E1A protein with DYRK1A and HIPK2 PMID: 27307198
7. Results associate a decreased level of DYRK1A with Alzheimer's disease and challenge the use of DYRK1A inhibitors in peripheral tissues as treatment. PMID: 28632203
8. The locations of disruptive variants (truncating, missense, and splice site mutations), copy number variations, and chromosomal rearrangements affecting DYRK1A functions. DYRK1A is one of the most recurrent genes with disruptive single nucleotide variants implicated in Autism spectrum disorder. PMID: 29034068
9. we suggest that de novo dominant mutations in DYRK1A account for nearly 0.5% of severe developmental disorders due to substantially reduced kinase function PMID: 28053047
10. The data described herein provide the first identification of a DYRK1A-mediated site of phosphorylation on GLI1 within its NLS and may serve as a valuable mechanism for further understanding Hh signaling modulation. PMID: 28735864
11. DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation. PMID: 28235034
12. These results suggest that TT genotype derived from SNP rs8126696 of DYRK1A gene is a possible risk factor for sporadic Parkinson disease, especially for males in this Chinese Han population. PMID: 27546826
13. identified the significant associations of the GBA L444P mutation and DYRK1A rs8126696 T allele with the earlier age at onset (AAO) in Parkinson's disease (PD) patients, and the A allele at MS4A6A rs610932 with the delayed AAO of PD. PMID: 27085534
14. study uncovered a new regulatory mechanism of DYRK1A degradation by SCF(betaTrCP) in HEK293 cell cycle progression. PMID: 27807027
15. Identify Dyrk1a as a novel negative regulator of D-cyclin-mediated Rb1/E2f-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy. PMID: 27056896
16. The deleterious effect of DYRK1A triplication in the formation of the cerebral cortex begins at the onset of neurogenesis, which is relevant to the search for early therapeutic interventions in Down syndrome. PMID: 26137553
17. mutations in DYRK1A define a syndromic form of autism spectrum disorder and intellectual disability with neurodevelopmental defects consistent with murine and Drosophila knockout models PMID: 25707398
18. Cyclin D1 Again Caught in the Act: Dyrk1a Links G1 and Neurogenesis in Down Syndrome. PMID: 26137545
19. data indicate that host factor DYRK1A plays a role in the regulation of viral transcription and latency. PMID: 26641855
20. Inhibition of DYRK1A and GSK3B induces human beta-cell proliferation PMID: 26496802
21. A de novo splice site mutation and a de novo nonsense mutation in DYRK1A were identified in two patients with syndromic intellectual disability. PMID: 26922654
22. RNA-seq evidence of biallelic expression of DYRK1A and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of DYRK1A is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. PMID: 27100087
23. Our report represents the largest cohort of individuals with DYRK1A disruptions to date, and is the first attempt to define consistent genotype-phenotype correlations among subjects with 21q22.13 microdeletions and DYRK1A SNVs or small INDELs. PMID: 25944381
24. We identified unique truncating and non-synonymous mutations (three nonsense, four frameshift and two missense) in DYRK1A in nine patients and a large chromosomal deletion that encompassed DYRK1A in one patient PMID: 25920557
25. the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection. PMID: 26534959
26. novel mutations in DYRK1A contribute to the phenotype of the DYRK1A-associated developmental disorder PMID: 25641759
27. findings suggest that truncation/activation of Dyrk1A by Ca(2+)/calpain I might contribute to Tau pathology via promotion of exon 10 exclusion and hyperphosphorylation of Tau in AD brain PMID: 25918155
28. Then we used this method to analyse human plasma DYRK1A levels in patients with AD biologically confirmed (positive CSF biomarkers and PiB-PET) and controls defined by normal cognitive performances and negative PiB-PET imaging. PMID: 25116835
29. Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc. PMID: 24901999
30. Results show that DYRK1A associates with the promoters of genes actively transcribed by RNAPII, where it regulates transcription by locally phosphorylating CTD residues involved in transcriptional elongation. PMID: 25620562
31. Study shows that DYRK1A overexpression affects pathways involved in synaptogenesis and synaptic plasticity and influences excitation/inhibition balance toward inhibition PMID: 24801365
32. results demonstrate that the molecular chaperone TRiC/CCT is essential for correct protein folding, DYRK1A binding, and nuclear accumulation of WDR68. PMID: 25342745
33. Overexpression of DYRK1A may promote premature neuronal differentiation and contribute to altered brain development in Down syndrome. PMID: 24806449
34. DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1-mediated transcriptional repression. PMID: 24820035
35. This review suggested that DYRK1A overexpressure in brain is releate to Down syndrome. PMID: 24152332
36. This study supports the hypothesis that intracellular distribution and compartment-specific functions of DYRK1A may depend on its phosphorylation pattern. PMID: 24327345
37. Dyrk1A does not enhance tau gene transcription, but does increase tau mRNA stability. PMID: 23948904
38. DYRK1A overexpression in a developmental alteration of the central nervous system associated with Down syndrome. PMID: 23512985
39. Dosage of Dyrk1a repositions cells within a p21-CycD1 signaling map, directing each cell to either proliferate or to follow two distinct cell cycle exit pathways characterized by high or low CycD1 and p21 levels. PMID: 24119401
40. A fundamental role for the dual-specificity tyrosine phosphorylation-regulated kinase, DYRK1A, in regulating EGF receptor in glioblastomas. PMID: 23635774
41. The DYRK1A gene is a cause of syndromic intellectual disability with severe microcephaly and epilepsy. PMID: 23099646
42. Coexpression of Dyrk1A and splicing factor 9G8 leads to their translocation from the nucleus to the cytoplasm and suppresses their ability to regulate tau exon 10 splicing. PMID: 21215488
43. A negative correlation was detected between BDNF and DYRK1A levels in lymphoblastoid cell lines with complete aneuploidy of human chromosome 21. PMID: 22669612
44. our results highlight the role played by DYRK1A in brain development through the control of choline acetyltransferase expression PMID: 23124096
45. This study demonistrated that the Gene dosage-dependent association of DYRK1A with the cytoskeleton in the brain and lymphocytes in patient with down syndrome patients PMID: 23147510
46. Mnb/Dyrk1a regulates food intake through the evolutionary conserved Sir2-FOXO-sNPF/NPY pathway in Drosophila melanogaster and mammals. PMID: 22876196
47. Phosphorylation of SRp55 by Dyrk1A suppressed its ability to promote Tau exon 10 inclusion. PMID: 22767602
48. This study showed Dyrk1A is shown to interact with and phosphorylate Munc18-1 at the Thr479 residue PMID: 22765017
49. This study demonistrated that a significant association between a polymorphic marker for DYRK1A and alpha-synuclein dementias. PDD. PMID: 22269890
50. analysis of phosphorylation regulated kinase 1A (DYRK1A) inhibitors PMID: 22154664

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HGNC: 3091

OMIM: 600855

KEGG: hsa:1859

STRING: 9606.ENSP00000381932

UniGene: Hs.368240