DYRK1A (Dual-specificity tyrosine phosphorylation-regulated kinase 1A) is a dual-specificity kinase that regulates the phosphorylation of tyrosine and serine/threonine residues, playing a critical role in various biological processes. It is involved in regulating key biological functions such as the cell cycle, cell proliferation, cell differentiation, and apoptosis. The structure of DYRK1A includes an N-terminal kinase domain, a C-terminal peptide-binding domain, and a conserved central region. Within signaling pathways, DYRK1A interacts with multiple substrates and modulates their activity and stability through phosphorylation. It also interacts with numerous signaling pathway proteins, influencing the complexity of intracellular signal transduction networks. DYRK1A has garnered widespread attention in research and clinical applications. Its abnormal expression or mutations are associated with the pathogenesis of various diseases such as Down syndrome, neurodegenerative disorders, and cancer.
● DYRK1A Antibody (Code: CSB-PA002232)
Validated Data
Western Blot analysis of HepG2 cells using Dyrk1A Polyclonal Antibody
Western Blot analysis of VEC cells using Dyrk1A Polyclonal Antibody
● Recombinant Human Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
Source: Yeast
Source: E.coli
Source: In Vivo Biotinylation in E.coli
Source: Baculovirus
Source: Mammalian cell
The following DYRK1A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
DYRK1A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA002232 | DYRK1A Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
DYRK1A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP614437HU CSB-EP614437HU CSB-BP614437HU CSB-MP614437HU CSB-EP614437HU-B |
Recombinant Human Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |